African Journal of Microbiology Research
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Article Number - 724ABC064697


Vol.11(22), pp. 915-919 , June 2017
DOI: 10.5897/AJMR2017.8432
ISSN: 1996-0808



Full Length Research Paper

Antimicrobial activity and FTIR characterization of lapachol derivatives against Staphylococcus aureus



Antonio Wilton Cavalcante Fernandes
  • Antonio Wilton Cavalcante Fernandes
  • Programa de Recursos Naturais do Semiárido – PgRNS of Federal University of São Francisco Valley, Brazil.
  • Google Scholar
Victoria Laysna dos Anjos Santos
  • Victoria Laysna dos Anjos Santos
  • Pharmacy da Federal University of São Francisco Valley, Brazil.
  • Google Scholar
Cleonia Roberta Melo Araujo
  • Cleonia Roberta Melo Araujo
  • Collegiate Pharmaceutical Sciences da Federal University of São Francisco Valley, Brazil.
  • Google Scholar
Edigenia Cavalcante da Cruz Araujo
  • Edigenia Cavalcante da Cruz Araujo
  • Collegiate Pharmaceutical Sciences da Federal University of São Francisco Valley, Brazil.
  • Google Scholar
Helinando Pequeno de Oliveira
  • Helinando Pequeno de Oliveira
  • Federal University of São Francisco Valley, Brazil.
  • Google Scholar
Mateus Matiuzzi da Costa
  • Mateus Matiuzzi da Costa
  • Federal University of São Francisco Valley, Brazil.
  • Google Scholar







 Accepted: 06 February 2017  Published: 14 June 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Lapachol is a natural naphthoquinone with important activity due to its chemical and structural properties. Nine semisynthetic derivatives of this substance were tested against strains of Staphylococcus spp. to identify the antimicrobial activity of these compounds. Only β-lapachone and oxime of lapachol showed good activity against the strains studied. The minimum bactericidal concentration values ranged from 62.5 to 15.62 μg/mL. The antimicrobial activity of these substances may be related to functional groups characteristics by technique Fourier transform infrared spectroscopy. There is great antimicrobial potential mainly related to β-lapachone and to oxime of lapachol, instigating further studies on the mechanisms of action.

Key words: β-Lapachone, lapachol oxime, spectroscopic analyses.

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APA Fernandes, A. W. C., Santos, V. L. A., Araújo, C. R. M., Araújo, E. C. C., de Oliveira, H. P., & da Costa, M. M. (2017). Antimicrobial activity and FTIR characterization of lapachol derivatives against Staphylococcus aureus. African Journal of Microbiology Research, 11(22), 915-919.
Chicago Antônio Wilton Cavalcante Fernandes, Vict&oria Laysna dos Anjos Santos, Cleônia Roberta Melo Ara&ujo, Edigênia Cavalcante da Cruz Ara&ujo, Helinando Pequeno de Oliveira and Mateus Matiuzzi da Costa. "Antimicrobial activity and FTIR characterization of lapachol derivatives against Staphylococcus aureus." African Journal of Microbiology Research 11, no. 22 (2017): 915-919.
MLA Antocirc;nio Wilton Cavalcante Fern, et al. "Antimicrobial activity and FTIR characterization of lapachol derivatives against Staphylococcus aureus." African Journal of Microbiology Research 11.22 (2017): 915-919.
   
DOI 10.5897/AJMR2017.8432
URL http://www.academicjournals.org/journal/AJMR/article-abstract/724ABC064697

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