African Journal of
Microbiology Research

  • Abbreviation: Afr. J. Microbiol. Res.
  • Language: English
  • ISSN: 1996-0808
  • DOI: 10.5897/AJMR
  • Start Year: 2007
  • Published Articles: 4829

Full Length Research Paper

Antimicrobial activity and FTIR characterization of lapachol derivatives against Staphylococcus aureus

Antonio Wilton Cavalcante Fernandes
  • Antonio Wilton Cavalcante Fernandes
  • Programa de Recursos Naturais do Semiárido – PgRNS of Federal University of São Francisco Valley, Brazil.
  • Google Scholar
Victoria Laysna dos Anjos Santos
  • Victoria Laysna dos Anjos Santos
  • Pharmacy da Federal University of São Francisco Valley, Brazil.
  • Google Scholar
Cleonia Roberta Melo Araujo
  • Cleonia Roberta Melo Araujo
  • Collegiate Pharmaceutical Sciences da Federal University of São Francisco Valley, Brazil.
  • Google Scholar
Edigenia Cavalcante da Cruz Araujo
  • Edigenia Cavalcante da Cruz Araujo
  • Collegiate Pharmaceutical Sciences da Federal University of São Francisco Valley, Brazil.
  • Google Scholar
Helinando Pequeno de Oliveira
  • Helinando Pequeno de Oliveira
  • Federal University of São Francisco Valley, Brazil.
  • Google Scholar
Mateus Matiuzzi da Costa
  • Mateus Matiuzzi da Costa
  • Federal University of São Francisco Valley, Brazil.
  • Google Scholar


  •  Accepted: 06 February 2017
  •  Published: 14 June 2017

Abstract

Lapachol is a natural naphthoquinone with important activity due to its chemical and structural properties. Nine semisynthetic derivatives of this substance were tested against strains of Staphylococcus spp. to identify the antimicrobial activity of these compounds. Only β-lapachone and oxime of lapachol showed good activity against the strains studied. The minimum bactericidal concentration values ranged from 62.5 to 15.62 μg/mL. The antimicrobial activity of these substances may be related to functional groups characteristics by technique Fourier transform infrared spectroscopy. There is great antimicrobial potential mainly related to β-lapachone and to oxime of lapachol, instigating further studies on the mechanisms of action.

Key words: β-Lapachone, lapachol oxime, spectroscopic analyses.