African Journal of Biochemistry Research
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Article Number - E3A230158333


Vol.10(3), pp. 20-24 , March 2016
https://doi.org/10.5897/AJBR2015.0866
ISSN: 1996-0778


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Full Length Research Paper

Antihyperlipidaemic and anti-atherosclerotic activities of aqueous leaf extract of L. africana in streptozotocin induced diabetic rats



Uwakwe Augustine A.
  • Uwakwe Augustine A.
  • Department of Biochemistry, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria.
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Miikue-Yobe Togenu F. B.
  • Miikue-Yobe Togenu F. B.
  • Department of Science Laboratory Technology, Rivers State Polytechnic, Bori, Rivers State, Nigeria.
  • Google Scholar
Akaninwor Joyce O.
  • Akaninwor Joyce O.
  • Department of Biochemistry, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria.
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Felix-Samuel Barisi
  • Felix-Samuel Barisi
  • Department of Science Laboratory Technology, Rivers State Polytechnic, Bori, Rivers State, Nigeria.
  • Google Scholar







 Received: 20 October 2015  Accepted: 29 March 2016  Published: 31 March 2016

Copyright © 2016 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Hyperlipidaemia is a usual and life threatening complication of diabetes mellitus. Consequently, a good anti-diabetic agent should reduce the progression of this complication. In view of this, the anti-hyperlipidaemic and anti-atherogenic activities of aqueous extract of Lasianthera africana was studied in streptozotocin induced diabetic rats. Extract treatment was administered at a dose of 1ml of 180 mg/ml of extract per kg body weight once daily for three weeks (21 days). Blood samples were collected thereafter by cardiac puncture for the analysis of lipid profile after the rats were exposed to chloroform vapour for 5 min. Results show that extract treatment caused significant (p<0.05) reduction in all lipid parameters analyzed when compared to the diabetic control. The reduction in total cholesterol was more for low density lipoprotein (LDL) (90%) than high density lipoprotein (HDL) (69%) by extract treatment when compared to the diabetic control by 94 and 75 percent respectively. The extract also caused significant (p < 0.05) reduction in cardiac risk ratio (CRR), atherogenic index of plasma (AIP) and the atherogenic coefficient respectively. The result therefore shows that the aqueous extract of L. africana possess anti-hyperlipidaemic and anti-atherosclerotic activities, a justification for its use by ethno-botanist in the treatment of diabetic complications.

 

Key words: Anti-hyperlipidaemia, anti-atherosclerotic, atherogenic coefficient, cardiac risk ratio, atherogenic index of plasma, Lasianthera africana.

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APA Uwakwe A. A., Miikue-Yobe T. F. B., Akaninwor J. O., & Felix-Samuel B. (2016). Antihyperlipidaemic and anti-atherosclerotic activities of aqueous leaf extract of L. africana in streptozotocin induced diabetic rats. African Journal of Biochemistry Research , 10(3), 20-24.
Chicago Uwakwe Augustine  A., Miikue-Yobe Togenu F. B., Akaninwor Joyce O. and Felix-Samuel Barisi. "Antihyperlipidaemic and anti-atherosclerotic activities of aqueous leaf extract of L. africana in streptozotocin induced diabetic rats." African Journal of Biochemistry Research 10, no. 3 (2016): 20-24.
MLA Uwakwe Augustine A., et al. "Antihyperlipidaemic and anti-atherosclerotic activities of aqueous leaf extract of L. africana in streptozotocin induced diabetic rats." African Journal of Biochemistry Research 10.3 (2016): 20-24.
   
DOI https://doi.org/10.5897/AJBR2015.0866
URL http://www.academicjournals.org/journal/AJBR/article-abstract/E3A230158333

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