African Journal of Biochemistry Research
Subscribe to AJBR
Full Name*
Email Address*

Article Number - 0F1657462351


Vol.11(1), pp. 1-5 , January 2017
https://doi.org/10.5897/AJBR2014.0775
ISSN: 1996-0778


 Total Views: 0
 Downloaded: 0

Full Length Research Paper

Effects of Xylopia aethiopica fruit extract on isolated rabbit ileum



Okwari O.O.
  • Okwari O.O.
  • Department of Physiology, Cross River University of Technology, Okuku Campus, Nigeria.
  • Google Scholar
Obembe A.O.
  • Obembe A.O.
  • Department of Physiology, University of Calabar, Calabar, Nigeria.
  • Google Scholar
Jeje S.O.
  • Jeje S.O.
  • Department of Physiology, Cross River University of Technology, Okuku Campus, Nigeria.
  • Google Scholar
Honesty E.E.
  • Honesty E.E.
  • Department of Physiology, University of Calabar, Calabar, Nigeria.
  • Google Scholar
Osim E.E.
  • Osim E.E.
  • Department of Physiology, University of Calabar, Calabar, Nigeria.
  • Google Scholar







 Received: 06 May 2014  Accepted: 29 March 2016  Published: 31 January 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


In this study, pharmacological reactivity of rabbit ileum to crude extract of fruits of Xylopia aethiopica in the presence of other agonist and antagonist agents was evaluated. The contractility of the isolated rabbit ileum was recorded using kymograph. The effects of the crude extract of X. aethiopica on rabbit ileum were independently determined using a dose range of 10-8 to 10-4 mg/ml. However, to determine the effects of the extract on rabbit ileum in the presence of other agonist and antagonist a constant dose of 10-4 mg/ml of the extract was used. The result showed that the crude extract of X. aethiopica, nifedipine only and serotonin only produced a significant (p<0.001) dose dependent relaxation of the ileum muscle. Addition of the extract to nifedipine shifted the graph to the right. Administration of CaCl2 alone produce a dose dependent contraction of the rabbit ileum with negative correlation coefficient (p<0.001). Co-administration of CaCl2 with the extract shifted the CaCl2 response curve to the left.  Addition of extract to serotonin caused a significant (p<0.01) decreased in the relaxation of the rabbit ileum. In conclusion, this study suggests that X. aethiopica has smooth muscle relaxant effects on rabbit ileum and as such may reduce gastrointestinal motility.
 
Key word: Xylopia aethiopica, smooth muscle, Ileum, motility, agonist.

Barminas JT, James MK, Abubaka UM (1999). Chemical composition of seeds and oil of Xylopia aethiopica grown in Nigeria. Plant Foods Hum. Nutr. 53(3):193-198.
Crossref

 

Choumessi AT, Danel M, Chassaing S, Truchet I, Penlap VB, Pieme AC, Asonganyi T, Ducommun B, Valette A (2012). Characterization of the antiproliferative activity of Xylopia aethiopica. Cell Div. 7(1):8-15.
Crossref

 
 

da Silva TMS, da Silva BA, Mukherjee R (1999). The monoterpene alkaloid canthyeyine from strychnos trinervis root and its spasmolytic properties. Phytomed. 6(3):169-176.
Crossref

 
 

Ebong OO, Warison BA, Orupabo I (1995). The gastrointestinal inhibitory actions of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) in rats. West Afr. J. Pharmacol. Drug Res. 11(1):94-98.

 
 

Ebong, Shode FO (2000). Inhibitory effects of aqueous and petroleum ether extracts of the fruit of Xylopia aethiopica (Dunal A. Rich (Annonaceae)) on rats uterine muscle. J. Med. Med. Sci. 2(1):45-51.

 
 

Ekong DE, Ogan AU (1968). Chemistry of the constituent of Xylopia aethiopica. The structure of xylopic acid a diterpene acid. J. Chem. Soc. 54:311-312.
Crossref

 
 

Iwu MW, Duncan AR, Okunji CO (1993). New antimicrobial of plant origin. In Jankick J. (Eds). Perspective of new crops and uses AIIS press. Alexandria VA. pp. 457-462.

 
 

Nwafor A, Kalio ID (2006). Physiological effects of Xylopia aethiopica on pregnancy in albino rats. J. Med. Pharmacol. Sci. 2(1):1-4.

 
 

Okwari OO, Dasofunjo K, Obembe AO, Olatunji TL, Osim EE (2014). Xylopia aethiopica fruit extract lowers uric acid levels in wistar albino rats. Int. J. Pharm. Biol. Sci. 9(1):46-50.

 
 

Wouters MM, Farrugia G, Schemann (2007): 5-HT receptors on interstitial cells of cajal smooth muscle and enteric nerves. J. Neurogastroenterol. Motil. 19(2):5-12.
Crossref

 

 


APA Okwari, O. O., Obembe, A. O., Jeje, S. O., Honesty, E. E., & Osim, E. E. (2017). Effects of Xylopia aethiopica fruit extract on isolated rabbit ileum. African Journal of Biochemistry Research , 11(1), 1-5.
Chicago Okwari O.O, Obembe A.O, Jeje S.O, Honesty E.E and Osim E.E. "Effects of Xylopia aethiopica fruit extract on isolated rabbit ileum." African Journal of Biochemistry Research 11, no. 1 (2017): 1-5.
MLA Okwari O.O, et al. "Effects of Xylopia aethiopica fruit extract on isolated rabbit ileum." African Journal of Biochemistry Research 11.1 (2017): 1-5.
   
DOI https://doi.org/10.5897/AJBR2014.0775
URL http://www.academicjournals.org/journal/AJBR/article-abstract/0F1657462351

Subscription Form