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  J. Med. Plants Res.

 

  Vol. 4 No. 4
 

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  Zhang JY

  Yu LH


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Journal of Medicinal Plants Research Vol. 4(4), pp. 335–338, 18 February 2010

ISSN 1996-0875 © 2010 Academic Journals  

   

 

Full Length Research Paper

 

  
 

Assignments of 1H and 13C NMR signals of Euphorbia factor L1 and investigation of its anticancer activity in vitro

 

Jian-ye Zhang1*, Chao Zhang1, Hu-biao Chen2, Li-wu Fu3, Yi-wen Tao1, Xiao-qiong Zheng1, Zhi-min Cao1, Yue-fei Zhong1 and Li-hong Yu1

 

1Department of Pharmaceutical Sciences, School of Basic Science, Guangzhou Medical College, Guangzhou 510182, People's Republic of China.

2School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China.

3State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou 510060, People's Republic of China.

 

*Corresponding author. E-mail: jianyez2003@yahoo.com.cn. 

Tel: 86-20-81340993. Fax: 86-20-81340163.

 

Accepted 28 January, 2010
 
     
 

 Abstract

  
     
 

In this article, we reported the isolation and characterization of Euphorbia factor L1 from Caper Euphorbia seed. The complete 1H and 13C NMR signals were assigned with the help of 1D, 2D NMR techniques. In addition, the anticancer activities of Euphorbia factor L1 were investigated. It exhibited potent cytotoxicity to KB, KBv200, MCF-7 and MCF-7/ADR cells with the IC50 values of 30.83 ± 2.93, 28.11 ± 3.08, 39.47 ± 4.03 and 42.69 ± 4.27 μg/ml, respectively.

 

Key words: Caper Euphorbia seed, NMR signals, anticancer activity.

  

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