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Cisplatin induced histological changes in renal tissue of
rat
Pratibha Ravindra1*, Dayanand A. Bhiwgade2,
Sameer Kulkarni3, Padmanabh V. Rataboli4
and Chitra Y. Dhume5
1Department
of Life Sciences, University of Mumbai, Kalina, Santacruz
(E) 400098, Mumbai, India.
2Department
of Biological Sciences, D. Y. Patil University, Belapur,
Navi Mumbai, India.
3Department
of Biochemistry, Grant Medical College and Sir J. J. Group of
Hospitals, Byculla, Mumbai, India.
4Department
of Pharmacology, Goa Medical College, P. O. Bambolim
Complex, Goa 403001, India.
5Department
of Biochemistry, Goa Medical College, P. O. Bambolim
Complex, Goa 403001, India.
*Corresponding author. E-mail:
prati86@hotmail.com.
Tel: [022] 25328178.
Accepted 30 June, 2010. |
The present study reviews the effect of
anticancer drug cisplatin regimens on the renal
histopathological and ultrastructure of male
rat. The kidney being an essential organ of
metabolism and elimination of most of the toxic
components, it serves as very important site of
attack by various chemical agents including
cisplatin, in the form of its activated
metabolite. In our study, all the induced
alterations revealed acute tubular necrosis
along with dilation and slogging of epithelium
seen in its light microscopic structure whereas,
ultrastructural changes showed absence of
microvilli in few sections. Several rounded
cisternae of SER and presence of dense chromatin
in the nucleus with increased mitochondrial
density is also one of the noticeable changes
seen after drug treatment. The damage, which is
irreversible at certain dose level, might cause
potential damage to the organ, which can be
overcome by designing proper dose regimen and
monitoring and by giving it in combination with
anti-cancer drugs.
Key words:
Cisplatin, necrosis, kidney
.
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