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Existence of snoRNA,
microRNA, piRNA characteristics in a novel non-coding RNA:
x-ncRNA and its biological implication in Homo sapiens
Kandhavelu Meenakshisundaram,* Lammi Carmen, Buccioni
Michela, Dal Ben Diego, Volpini Rosaria, Marucci Gabriella.
Pharma Biotech lab, Department of Chemical Science,
University of Camerino,
Via S. Agostino 1, Camerino (MC) - 62032, Italy.
*Corresponding author. E-mail:
imsk1982@gmail.com.
Tel: +358403553659.
Fax:
+358 17 163 030.
Accepted
6 June, 2009 |
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Comparative genomic analysis constitutes a powerful approach
for the systematic understanding of genome. The comparative
and evolutionary analysis of known microRNAs in Homo
sapiens elucidates the discovery of the existence of the
novel non-coding RNA, which is transcribed from the unique
gene precursor and produces three different non coding RNAs
such as piRNA, snoRNA and microRNA. This new characteristics
RNA is named as x-non coding RNA (x-ncRNA). This
characteristic pattern shows evolutionary signatures
dictated by its precise selective significance and synteny.
The evidence of x-ncRNA processing and functionality from
hairpin arms were proven by systematic analysis. x-ncRNA
analysis proven the bio genesis of human piRNA is originated
from the dsDNA, which is also involved in the synthesis of
piRNA and/or microRNA, through dicer. These data also shows
the presence of human sno-microRNA. Our data demonstrates
that the existence of x-ncRNA, genomic origin, conceivable
bio genesis pathway, evolutionary relationship and its
functions.
Key words:
snoRNA, microRNA, piRNA, Biogenesis, novel noncoding RNA
(x-ncRNA). |
