African Journal of
Pharmacy and Pharmacology

  • Abbreviation: Afr. J. Pharm. Pharmacol.
  • Language: English
  • ISSN: 1996-0816
  • DOI: 10.5897/AJPP
  • Start Year: 2007

AJPP Articles in press

Article in Press

RP-HPLC method development and validation for the simultaneous estimation of atorvastatin, simvastatin and rosuvastatin in bulk and pharmaceutical dosage form

This research was designed to develop and validate a precise, simple, rapid, reliable, more accurate, as well as least time consuming High-Performance Liquid Chromatography (HPLC) technique for simultaneous and individual estimation of atorvastatin, rosuvastatin and simvastatin in whole and in various formulations. This separation was attained chromatographically using blend of methanol and trifluroacetic acid (0.1%) in...

Author(s):Bhuvnesh Kumar Singh, Neelanchal Trivedi, Abhishek Bharadwaj and K. K. Jha

Article in Press

Evaluation of surgical antimicrobial prophylaxis use in Ethiopia: Prospective study

Appropriate use of surgical antimicrobial prophylaxis can prevent approximately 40 to 60% of surgical site infections. Inappropriate use is associated with emergency of antimicrobial resistance, occurrence of side effects and increased health care cost. We aimed to evaluate surgical antimicrobial prophylaxis use of Hawassa University Referral Hospital against standard guideline Prospective observational ...

Author(s):Tamrat Legesse, Desta Hiko, Eneb Khelifa Ismael and Sadikalmahdi Hussen Abdella

Article in Press

Impact of three modes of cooking on anticholinesterase, antioxidant activities and polyphenols content of eggplant Solanum melongena (Adria variety)

Nowadays, the growing interest in consumption of fruit and vegetables raises the question of cooking impact on their nutritional benefits. Growing evidence suggests that oxidative damage caused by the β-amyloid peptide in the pathogenesis of Alzheimer’s disease may be hydrogen peroxide mediated. Many polyphenols, the most abundant dietary antioxidants, possess stronger neuroprotection against hydrogen peroxide.The...

Author(s):Imen Laib, Malika Barkat and Abdulselam Ertas Mustafa abdullah yilmiz

Article in Press

Pharmacognostic and toxicological evaluation of the leaves of Piper guineense Schum. and Thonn (Piperaceae)

The leaves of Piper guineense Schum. and Thonn (Piperaceae) are used in ethnomedicine for the management/treatment of various diseases. The objective of this study was to establish the pharmacognostic and toxicological profiles of P. guineense to help practitioners in making choices, and to assist scientists involved in the research of the Piper genus. The fresh leaves were examined for their macroscopic and microscopic...

Author(s):Tavs A. Abere ⃰, Mumuni Sumaila and Obi Ifeoma Stephanie

Article in Press

Scientific and technological prospect of Platonia insignis Mart (Clusiaceae)

The chemodiversity and pharmacological potential of the flora are uncounted and allow the study of native plants, such as Platonia insignis Mart. (Clusiaceae), an exotic plant in Piaui, Brazil. Investigations on the chemical composition of the plant of the family Clusiaceae have shown that they are mainly rich in polysoprenylated benzophenones and xanthones, which have been isolated not only from the resins, but also from...

Author(s):George L. S. Oliveira, Ana Paula dos Santos C. L da Silva, José Carlos C. L. da Silva Filho, Joaquim S. da Costa Júnior, Jorge M. David and Rivelilson Mendes de Freitas

Article in Press

Neurohistological and immunohistochemical effects of prophylactic ethanolic leaf extract of Nauclea Latifolia and Artemether/Lumefantrine on the hippocampus of Plasmodium Berghei-infected mice

The prophylactic effect of ethanolic leaf extract of Nauclea latifolia, widely used in herbal malarial treatment, against the widely used drug Coartem® (Artemether/Lumefantrine) in Plasmodium-infected mice was investigated, and thereafter analysed for organosomatic index, parasitemia, histomorphological and immunohistochemical changes in the hippocampus. Twenty male mice about 6 to 8 weeks weighing 20 to 24 g were...

Author(s):Innocent A. Edagha, Inyang A. Atting and Moses U. Ekanemesang

Article in Press

24 h pre-incubation of EA.hy926 cells with angiotensin II regulates insulin-dependent activation of eNOS in a concentration-dependent manner

The rennin-angiotensin II system (RAS) and the insulin-PI3kinase signalling pathways cross-interact with important physiological and pathophysiological consequences for cells and the whole organism. Here, the effect of 24 h pre-incubation of EA.hy926 with two different concentrations of angiotensin II, on insulin-mediated activation of the PI3kinase-AKT-eNOS signalling was investigated. Quiescent EA.hy926 cells were...

Author(s):Ejebe D. E.

Article in Press

A review on chemical and pharmacological profile of a novel class of antihyperglycemic drugs: Dipeptidyl protease-4 inhibitors

The dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of anti hyperglycemic agents which were developed for the treatment of type-2 diabetes mellitus by rational drug design, based on an understanding of the mechanism of action and knowledge of the structure of the target enzyme. Glucagon-like peptide-1 (GLP 1) and gastric inhibitory polypeptide (GIP) are hormones secreted by the enteroendocrine cells of the gut in...

Author(s):Himanshu Joshi, Abdul Wadood Siddiqui, Zia Ur Rehman, Afrin Salma and Deepanshu Sharma

Article in Press

FORMULATION AND EVALUTION OF ORAL FAST DISSOLVING FILM OF FEXOFENADINE HYDROCHLORIDE BY QbD APPROACH

The objective of the present investigation was to formulate, evaluate and optimize oral film of Fexofenadine HCl using (Box Behnken) design. In the present investigation an attempt was made to develop mouth dissolving films of Fexofenadine HCl to achieve fast disintegration and dissolution characteristics with improved bioavailability by oral route. Oral films of Fexofenadine HCl were formulated using HPMC E15 premium...

Author(s):Bhusnure O.G

Article in Press

Hypoglycemic, hypolipidemic and kidney protective potential of combined formulation of Tribulus terrestris and Andrographis paniculata in alloxan induced mice

Objective(s): To evaluate the effect of Tribulus terrestris and Andrographis paniculata on body weight, blood glucose, lipid profile and renal protective capability in alloxan induced type-1 diabetic mice. Materials and methods: Six groups of five male Swiss Albino mice each, at four weeks of age were used in this experiment. Group-X were fed saline water and Group-Y with combined herbal formulation at a high dose (1 g/kg...

Author(s):stiak ASME, Hazra P, Das SR, Hossain MI, Aminatu AS, Rafiq K

Article in Press

Ethnomedicinal plants used for the treatment of gastro-intestinal parasitic diseases in human in Yeki district, Southwest Ethiopia

The use of medicinal plants plays a major role in the primary health care of human beings in Ethiopia. A study was carried out to document ethnomedicinal plants used for the treatment of gastrointestinal parasitic diseases of human in Yeki district, southwest Ethiopia. The key informants were selected using purposive sampling method. The information was obtained from 26 informants and 8 herbalists through the use of a...

Author(s):Belachew Garedew and Dagne Abebe

Article in Press

Utility of silver nanoparticles for the analysis of diosmin and rutin in Persicaria salicifolia extract, authentic and pharmaceutical dosage forms monitored with their haemostatic activity

The present work was conducted to evaluate a simple effective technique for spectrophotometric determination of two flavonoids namely diosmin (1) and rutin (2) in the isolated fractions obtained from Persicaria salicifolia, authentic and pharmaceutical dosage forms, the method is based on the reduction of Ag+ cations to silver nanoparticles (Ag-NPs) by the effect of these flavonoids in the presence of polyvinylpyrrolidone...

Author(s):Hesham Salem, Atef Ahmed Elhela and Nevein Mohamed Abdelhady

Article in Press

In vivo assessment of the antipyretic activity of tilmicosin

The aim of the present study was to assess the antipyretic activity of the macrolide antibiotic, tilmicosin, at dose levels of 20 and 40 mg/kg of body weight, subcutaneously, in Brewer's yeast-induced fever model in mice. Pyrexia was induced by subcutaneous injection of 20 mL/kg of 20% (w/v) Brewer’s yeast suspension into the animal’s scruff region. Eighteen hours later, feverish animals were treated with either tilmicosin...

Author(s):A. M. El-Mahmoudy, I. M. Gheith, A. A. Elmajdoub and S. K. Awidat

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