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Synthesis
and applications: Ten years of experience in monodentate,
bidentate, tridentate and macrocycle pyrazole heterocyclic
chemistry
Touzani Rachid1, 2, Ramdani Abdelkrim1
and El Kadiri Sghir1*
1Laboratoire
de Chimie Appliquée et Environnement, Département de Chimie,
Faculté des Sciences, Université Mohammed Premier, BP 524,
60 000 Oujda, Morocco.
2Faculté
Pluridisciplinaire de Nador, Université Mohammed Premier,
BP300, Selouane 62700, Nador, Morocco.
*Corresponding author: E-mail:
elkadiri_sghir@yahoo.fr,
touzanir@yahoo.fr.
Accepted 17 December, 2009. |
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Herein we report the development of efficient methods to
prepare monodentate, bidentate, tridentate and macrocycle
compounds based on pyrazole moieties, with the opportunity
to change easily structure, substituents, cavities or all
these parameters in the synthesis of huge library compounds.
These methods take advantage of the vast number of
commercially available starting materials containing
functional and aliphatic or aromatic amines. Such as
structural and electronic diversity makes these approaches
well suited to the production of large arrays of compounds
for potential application in medicinal, corrosion or
coordination chemistry.
Key words:
Pyrazole, bipyrazole, bis pyrazole, N-donor electron rich,
macrocycle. |
