Abbreviation: Res. Pharm. Biotech.
Start Year: 2009
Page 1 of 3, showing 20 records out of 41 total, starting on record 1, ending on 20
DOI: 10.5897/RPB2011. 030[Article Number: B06AC9955427]
Nepata cateria (Labiatae) growing widely in northern Nigeria is used by most indigenes for the treatment of malaria and other related diseases. The in vivo anti-malarial activity of the methanol leaf extract was evaluated in mice infected with the chloroquine sensitive Plasmodium berghei berghei NK65 strain. Oral acute toxicity of the methanol leaf extract with modified Lorke`s method was evaluated against early,... Read more.
DOI: 10.5897/RPB2015. 0101[Article Number: 56BA97955013]
Diabetic neuropathy is one of the most common diabetic complications, associated with long time exposure to high glucose. Hyperglycemia induces the production of reactive oxygen species (ROS) and reactive nitrogen species contributing to neuronal damage. We have previously reported that HAMI 3379, a selective antagonist of CysLT2 receptor, is involved in neuron injury after ischemia. In this study, we investigated the... Read more.
DOI: 10.5897/RPB13.0095[Article Number: 24CC1CE49464]
The following alkaloids were isolated from Catharanthus roseus L. leaves from the yellow crystal as white powder at (38°C). The chemical and physical properties were studied by thin layer chromatography (TLC), IR-spectrum (IR), Ultraviolet - visible spectrum (UV) and melting point (mp). Standard strains of bacteria: Staphylococcus aureus NCTC 6571, Escherichia coli NCTC 5933 and the clinical multidrug resistance... Read more.
DOI: DOI: 10.5897/RPB13.0088[Article Number: C078BF743689]
A series of new 2-Aryl-2,3-dihydro-1H-perimidine, derivatives (3a - j) were synthesized under reflux and at room temperature by condensation reaction of 1,8-diaminonaphthalene (2) with various substituted benzaldehyde using glacial acetic acid a catalyst. The synthesized compounds were characterized by spectroscopic methods, infrared (IR), proton nuclear magnetic resonance (1H-NMR), carbon nuclear magnetic resonance... Read more.
DOI: 10.5897/RPB13.0089[Article Number: 394F56643954]
Moringa oleifera Lam. (Moringaceae family) is a deciduous plant with tuber-like root at the earlier stage. Starch was isolated from the young tuber of the plant and examined instrumentally for its functional groups, X-ray diffractometer (XRD) profile, elemental analysis and antioxidant activities. The Fourier transform infrared spectroscopy analysis shows that peaks at 3465.23 to 3577.11 cm−1 represent... Read more.
DOI: 10.5897/RPB11.029[Article Number: EB53987496]
N-Hexane and water extracts of the leaves, stem-bark and roots of the indigenous plant Acacia tortilis locally reputed for the treatment of cough, malaria, asthma and stomach pain in Girei Local Government Area (LGA), Adamawa State were phytochemically screened and biologically tested against Escherichia coli, Shigella sp., Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus... Read more.
DOI: 10.5897/RPB12.002[Article Number: 264C36F498]
The potent of n-butanol extract of celery (Apium graveolens) seed in ameliorating the lipid peroxidation and antioxidant status was investigated in streptozotocin-induced diabetic rats. Thirty two mature male rats were assigned to four groups, non-diabetic control and three diabetic groups. Diabetes was induced by single injection with streptozotocin (60 mg/kg b.w., i.p.). Rats ≥ 200 mg/dl of blood... Read more.
DOI: 10.5897/RPB11.031[Article Number: D29FAE0493]
Comparative evaluation of Sesamum indicum gum as a binder in the formulation of paracetamol (PCM) granules and tablets was performed using acacia, gelatin, and Sodium carboxyl methylcellulose (SCMC) as standard binders for comparison. The properties of granules and tablets such as; flow rate, angle of repose, density, weight uniformity, crushing strength, friability, disintegration rate and release... Read more.
DOI: 10.5897/RPB11.032[Article Number: 27F0633494]
Several studies have shown that peroxisome proliferator-activated receptor-g (PPARg) agonists protect against ischemia/re-perfusion (I/R) damage in different organs. This study was carried out to assess the possible role of PPARg on intestinal I/R-mediated tissue injury. This was achieved by evaluating the effects of the PPARg agonist rosiglitazone and the PPARg antagonist bisphenol A... Read more.
DOI: 10.5897/RPB11.011[Article Number: A36C71F490]
The trafficking and abuse of Ketamine are a concern to law enforcement and drug treatment providers because of the drug’s increasing availability and its use in facilitating sexual assaults globally. The aim of this study is to investigate some of the effects of administration of ketamine intramuscularly (IM) on bebaviour in mice. The presumably 16 healthy male mice were used for this study; the... Read more.
DOI: 10.5897/RPB11.005[Article Number: E62570C491]
Typhoid fever (TF) is a systemic bacterial infection caused by Salmonella typhi, a facultative and gram negative rods. The infection is usually acquired through the ingestion of contaminated water or food. Almost 80% of cases and deaths occur in Asia. The attack rate as high as 1100 cases per 100000 populations have been documented in developing countries. In typhoid fever, various organs can be involved... Read more.
[Article Number: 412D887485]
The effects of feeding honey on normal and alloxan induced diabetes rats treated and untreated were studied. In the experimental design, 25 rats were divided into five groups of five rats each, with Groups I and II serving as the normal and diabetic control, while Groups III, IV and V were the diabetic test groups administered with glucophage 500 mg/kg, glucophage in combination with honey (500 and 10 mg) and... Read more.
[Article Number: 9CE6C51486]
Mechanism of quercetin for protection of endothelial cell was studied in cholesterol-fed rabbits. Thirtyrabbits were randomly divided into five groups. The negative control group was fed with a standard diet; the positive control group was fed with the same diet with 2% cholesterol; the quercetin group was fed with the same diet with 2% cholesterol... Read more.
[Article Number: 4357700488]
The incidence of death of broiler birds above 40 days suddenly increased in the month of July to October 2009 in Kathmandu valley. Birds that were presented for post-mortem examination at the Central Veterinary Laboratory Tripureswor Kathmandu were usually found dead on their backs with wings out-stretched. Gross abnormalities recorded on post mortem examinations were: muscle oedema, pulmonary, renal and... Read more.
[Article Number: 814DAC7482]
To improve the effectiveness of the public pharmacy, resources should be switched towards areas of need, reducing inequalities and promoting better health conditions. Medicines are financed either through cost sharing or full private. The role of the private services is significant. A review of reform of financing medicines in Sudan is given in this article. Also, it highlights the current drug supply system... Read more.
[Article Number: 7AD0075483]
Topical application with indole – 3 – butyric acid (IBA) showed a significant increase in glycogen, protein and total lipids in the body fat and trehalose and protein contents in the haemolymph in all the groups of the silkworm, Bombyx mori. Topical application with indole – 3 – pyruvic acid (IPA) showed a significant increase in glycogen, protein and total lipids in the body fat... Read more.
[Article Number: A3F5981479]
Preliminary phytochemical screening of Striga hermonthica was carried out to assess the chemical contents and biological activity of callus comparing to that of intact plant (upper and underground parts). The results show the presence of terpenes, tannins, coumarins, cardiac glycosides, flavonoids, saponins, anthracenosides and alkaloids. Further, ethanol extracts analysis-using thin layer... Read more.
[Article Number: 79E13F8477]
The ethanolic leaf extract of Pentas decora, a plant known in the local community as “Kabyakyasha” (in Runyankole Language), was evaluated for its antifungal activity against Candida albicans,Epidermophyton floccosum, Microsporum canis and Trichophyton rubrum, and qualitatively analyzed for its phytochemical composition. The disc diffusion method was employed to... Read more.
[Article Number: F718D9F481]
The radiomodulatory effect of guduchi extract (TCE) was studied in HeLa cells incubated with 0, 1, 2, 4, 6 or 8 µg/ml of TCE for 2 or 4 h before exposure to 0, 0.5, 1, 2, 3 or 4 Gy of g-radiation. The molecular DNA damage was assessed using alkaline comet assay, where DNA tail fragmentation olive tail moment (OTM) served as a measure of DNA damage. Exposure of HeLa... Read more.
[Article Number: EAD607E473]
The effect of the aqueous root extract of Talinum triangulare on the gastrointestinal system was evaluated in mice and rats using normal intestinal transit. Castor oil induced diarrhea and castor oil induced enteropooling models. The result obtained showed that, the effects of the aqueous root extract were dose dependent and biphasic in all the models used. The extract (500, 1000 and 2000 mg/kg) produced a... Read more.
Page 1 of 3, showing 20 records out of 41 total, starting on record 1, ending on 20