Abbreviation: J. Physiol. Pathophysiol.
Start Year: 2010
Page 1 of 2, showing 20 records out of 40 total, starting on record 1, ending on 20
DOI: 10.5897/JPAP2016.0107[Article Number: 5D782A462439]
Oxytocin (OXT) is a neuropeptide with a peripheral role in reproduction, though it may have a central effect. The aim of the study is to verify its cental pathophysiological mechanisms on experimental rats. Rats were divided into control, OXT (which divided into intrathecal OXT and IV OXT subgroups), and antagonist group: OXT and l-glutamate Na+ subgroup with measuring of pain threshold, cardiovascular changes, and pain... Read more.
DOI: 10.5897/JPAP2015.0104[Article Number: 39671F159720]
The World Health Organization (WHO) estimates that, about a quarter of the diseases facing mankind today occur due to prolonged exposure to environmental pollution, and that most of these environment-related diseases are however, not easily detected and may be acquired during childhood and manifested later in adulthood. The aim of this work was to determine the sub-chronic effects of lead poisoning on and some sex... Read more.
DOI: 10.5897/JPAP2015.0097[Article Number: 47D30A959164]
The interpretation of prolactin results is difficult as race related reference intervals are scarce, especially in Nigerian women. Serum prolactin reference intervals were determined from 120 subjects. Subjects were randomly selected from antenatal clinics and general outpatient clinics in one private hospital and three government hospitals in Zaria, Northern Nigeria. They consisted of six groups made up of women that... Read more.
DOI: 10.5897/JPAP2015.0101[Article Number: 7D0D18157876]
The aim of this study was to compare three correction methods of QT interval in African national level football players. QT interval was measured in D2 lead on resting electrocardiogram (ECG) in 216 Black male football players (age range 18 to 35 years). Corrected QT (QTc) was calculated using Bazett, Fridericia, and Framingham’s formulas. Means and percentages of long QT (QTc>440 ms and QTc≥470 ms) and... Read more.
DOI: 10.5897/JPAP2015.0099[Article Number: 69D127356897]
In this study, the effect of Gmelina arborea aqueous extract, a medicinal plant used in the treatment of hypertension, on rat blood pressure was investigated. After harvest, leaves of G. arborea were dried, reduced in powder and used for aqueous extract preparation. The aqueous extract was administrated at 500 mg/kg/day to Wistar rats, which has been made hypertensive by NG-Nitro-L-arginine methyl ester (L-NAME),... Read more.
DOI: 10.5897/JPAP2015. 0098[Article Number: DB7D07154528]
Reflux esophagitis is a common gastrointestinal disorder that affects the quality of life in patients. Esophagitis is a chronic disease that leads to inflammation of the esophagus. Ghrelin is a 28-amino acid peptide that has several endocrine and metabolic effects. The aim of this study was to investigate the effect of ghrelin on the esophagitis. Eighteen wistar rats were divided into three groups of six. Midline... Read more.
DOI: 10.5897/JPAP2014. 0089[Article Number: DB172EF51229]
Prior epidemiological studies and comparative analyses of correlations between abdominal obesity and dyslipidemia have been limited to obese participants but few data are available for the non-obese adults of this study population. This study examined the associations between atherogenic and obesity indices among non-obese adults of Samaru, a suburb of Zaria in Kaduna state, Nigeria. The study protocol was duly approved... Read more.
DOI: 10.5897/JPAP2014.0094[Article Number: 1652F5348578]
Tracheal hyperresponsiveness, airway mucus production and bronchoalveolar inflammation are the major components of asthma. Here, we aim to investigate the role in the control of asthma of a bioactive plant extracted from Hymenocardia acida in a physiological and pathophysiological model. The effect of H. acida crude extract (HACE) on total cellular components of bronchoalveolar (BAL) fluids was performed on ovalbumin... Read more.
DOI: 10.5897/JPAP2014.0091[Article Number: 6E9EADA46984]
In this study we investigated if ghrelin plays a protective role against paracetamol-induced acute hepatotoxicity in rats and the possible mechanism of action. Forty adult male albino rats were divided into four equal groups; control, ghrelin, paracetamol and ghrelin plus paracetamol. Evaluations were made for lipid peroxidation, enzyme activities and biochemical parameters. Liver histopathology was also performed.... Read more.
DOI: 10.5897/JPAP2013.0085[Article Number: 7271FD345051]
Excessive height loss in postmenopausal women (PMW) has been found to reflect low bone mass; an index helpful in predicting vertebral fractures. One hundred and sixty five women were recruited for the cross-sectional study comprising of 77 premenopausal women who served as control and 88 PMW who constituted the study group. The subjects were administered a questionnaire after obtaining informed consent. While their... Read more.
DOI: 10.5897/JPAP2013.0081[Article Number: 35AB6EA41970]
Arsenite (Arsenic III) is ubiquitous and a widely distributed environmental toxin implicated in the aetiology of several neurological disorders. It is found in sea food, chemicals and pesticides. As(III) is also a mitochondria poison that induces reactive oxygen species (ROS) formation and membrane distortion. This study is aimed at proposing an in vitro method to detecting neural activity in rat’s brain treated... Read more.
DOI: 10.5897/JPAP2013.0083[Article Number: 208BB8B41972]
The present study aimed to evaluate cardio-protective effect of Nigella sativa oil (NSO) on lead induced cardio toxicity. Forty five albino adult rats were randomly divided into 3 groups: control lead (Pb) group that received lead acetate (20 mg/kg/day) 3 times weekly for 8 weeks and PB + NSO group (rats pretreated with Nigella sativa oil (4 ml/kg) orally for 1 h before administration of lead acetate (given as in Pb... Read more.
DOI: 10.5897/JPAP2013.0001[Article Number: 974E7B515872]
The aim of this paper is to review the information on type 1 and type 2 diabetes with emphasis on its etiology, pathogenesis and pathophysiology via literature review. Diabetes is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. Type 1 diabetes is the result of an autoimmune reaction to proteins of the islets cells of... Read more.
DOI: 10.5897/JPAP2013.0078[Article Number: 497CABC15892]
Quantitative, descriptive, cross-sectional study was conducted to determine the level of knowledge and extent of computer vision syndrome (CVS) among computer users at the Securities and Exchange Commission (SEC), Abuja, Nigeria. Structured questionnaire was administered to 100 computer users aged between 18 and 40 years. The findings showed that 40% of the participants were aware of CVS; of which 27% had knowledge of... Read more.
[Article Number: F9DD810623]
High-sensitivity C-reactive protein (hsCRP) is predictor of cardiovascular disease (heart attack, stroke) in apparently healthy individuals (Pfützner et al., 2004). Very few studies have specifically evaluated the usefulness of hsCRP as a marker of insulin resistance in normoglycemic young adults. The aim of this study was to assess whether hsCRP can be used to detect insulin resistance in normoglycemic... Read more.
[Article Number: BE6A5E2628]
In our previous studies, pharmacological actions of Senegalese plants on the modulation of tracheal contractile responses induced by acetylcholine were demonstrated. Here, we aim to demonstrate whether the pharmacological effects previously observed, could be obtained with other contractile agonists, such as histamine and potassium chloride (KCI), in the isolated trachea after treatment with the same... Read more.
[Article Number: 1C78FC1616]
A comparative analysis of blood component usage and wastage was performed in the Nukem Blood Bank and Rotary Suzlon Blood Component Center, Haria L. G. Rotary Hospital (Vapi) during 2007 and 2008. Reasons for wastage of blood components and trends for reducing blood component wastage... Read more.
[Article Number: 33011B8612]
The Millennium Development Goals include an aspect of children's health. The main purpose of this study was to indicate possible changes in different blood cells on one hand and secondly to establish standards of various parameters of the counts in the blood. The study involved 1,157 children aged 5 to 18 years in four selected municipalities of Abidjan. Blood sampling was done fasting in the morning,... Read more.
[Article Number: A4075AB598]
The aim of this paper is to study the effect of yogic exercise on respiratory system in middle aged men. The objective of the study is to assess respiratory parameter in both groups. For the study, we selected 90 healthy volunteers between age group 35 to 50. They were divided into 2 groups: 1) control group (45); and 2) study group (yoga) (45). Control group did not perform any exercise or yoga during 6... Read more.
[Article Number: 94C7101604]
The aim of the study was to investigate if Matrix metalloproteinase 2 (MMP2) and Matrix metalloproteinase 9 (MMP9) influence epithelial sodium channel (ENaC) current. Pleural membranes from sheep were mounted at Ussing chambers and were voltage-clamped. MMP2 and MMP9 were applied apically to the pleural membranes and amiloride was added to all experiments. All values are expressed as mean ± standard... Read more.
Page 1 of 2, showing 20 records out of 40 total, starting on record 1, ending on 20