Journal of
Physiology and Pathophysiology

  • Abbreviation: J. Physiol. Pathophysiol.
  • Language: English
  • ISSN: 2141-260X
  • DOI: 10.5897/JPAP
  • Start Year: 2010

JPAP Articles

March 2018

Preliminary study of physiopathological changes associated with the ethanolic extract of the stem leaves of Phyllanthus amarus in rats

The present work aimed to investigate physiopathological changes associated with the ethanolic extract of the stem leaves of Phyllanthus amarus (EEt(OH) P.a. Exploratory tests are performed in vivo on Wistar albino rats. Analysis of the variation in body weight at the level of the batch having received, and the control group showed a slight weight drop 7 d after treatment. This variation is not significant (p>0.05)....

Author(s): MAHAMADOU DANDA Amina, ATTAKPA Sèlidji Eugène, BÉHANZIN Gbèssohélè Justin, AMOUSSA Abdou Madjid, LAGNIKA Latifou, AKOTÈGNON Rodrigue, YÉDOMONHAN Hounnankpon, SEZAN Alphonse, BABA-MOUSSA Farid and BABA- MOUSSA Lamine

January 2017

Oxytocin ameliorates the deleterious effect of pain in adult male rats

Oxytocin (OXT) is a neuropeptide with a peripheral role in reproduction, though it may have a central effect. The aim of the study is to verify its cental pathophysiological mechanisms on experimental rats. Rats were divided into control, OXT (which divided into intrathecal OXT and IV OXT subgroups), and antagonist group: OXT and l-glutamate Na+ subgroup with measuring of pain threshold, cardiovascular changes, and pain...

Author(s): Nessren M. Abd el-Rady, Omyma G. Ahmed, Ebtihal A. Abd El-Aziz, Ayman M.Osman and Amel Taha

July 2016

Age-related effects of lead poisoning on sex hormones in adult male Wistar rats

The World Health Organization (WHO) estimates that, about a quarter of the diseases facing mankind today occur due to prolonged exposure to environmental pollution, and that most of these environment-related diseases are however, not easily detected and may be acquired during childhood and manifested later in adulthood. The aim of this work was to determine the sub-chronic effects of lead poisoning on and some sex...

Author(s): A. B. Daku, A. I. Salisu and A. B. El-ta’alu

May 2016

Preliminary study on the establishment of reference intervals for serum prolactin for women in Zaria, Nigeria

The interpretation of prolactin results is difficult as race related reference intervals are scarce, especially in Nigerian women. Serum prolactin reference intervals were determined from 120 subjects. Subjects were randomly selected from antenatal clinics and general outpatient clinics in one private hospital and three government hospitals in Zaria, Northern Nigeria. They consisted of six groups made up of women that...

Author(s): Achie L. N., Okorie M., Olorunshola K. V. and Ayegbusi F. O.

March 2016

Comparative study of three methods for QT interval correction in African national level football players

The aim of this study was to compare three correction methods of QT interval in African national level football players. QT interval was measured in D2 lead on resting electrocardiogram (ECG) in 216 Black male football players (age range 18 to 35 years). Corrected QT (QTc) was calculated using Bazett, Fridericia, and Framingham’s formulas. Means and percentages of long QT (QTc>440 ms and QTc≥470 ms) and...

Author(s): Abdoulaye Ba, Abdou Khadir Sow,  Mor Diaw, Valentin Ouedraogo, Maïmouna Touré, Arnaud Jean Florent Tiendrebeogo, Ghislain Loubano-voumbi, Salimata Diagne Houndjo, Aissatou Seck,  Samuel Honoré Mandengue, Djibril Seck and Abdoulaye Samb,

January 2016

Effects of Gmelina arborea, Roxb (Verbenaceae) aqueous extract on arterial pressure of Wistar rats

In this study, the effect of Gmelina arborea aqueous extract, a medicinal plant used in the treatment of hypertension, on rat blood pressure was investigated. After harvest, leaves of G. arborea were dried, reduced in powder and used for aqueous extract preparation. The aqueous extract was administrated at 500 mg/kg/day to Wistar rats, which has been made hypertensive by NG-Nitro-L-arginine methyl ester (L-NAME),...

Author(s): Roland Lawson, Bonaventure Awede, Razack Osseni, Fernand Gbaguidi, Joachim Gbenou and Anatole Laleye

July 2015

Effects of exogenous ghrelin on experimental reflux esophagitis model in male rat

Reflux esophagitis is a common gastrointestinal disorder that affects the quality of life in patients. Esophagitis is a chronic disease that leads to inflammation of the esophagus. Ghrelin is a 28-amino acid peptide that has several endocrine and metabolic effects. The aim of this study was to investigate the effect of ghrelin on the esophagitis. Eighteen wistar rats were divided into three groups of six. Midline...

Author(s): Seyed Mahdi Mohamadi, Fatemeh Nabavizadeh, Mahdieh Faghihi, Gholamreza Hasanzadeh, Hamideh Afzali and Hamid Sohanaki

March 2015

Association of atherogenic indices and abdominal obesity indices among non obese adults in Zaria, Northern Nigeria

Prior epidemiological studies and comparative analyses of correlations between abdominal obesity and dyslipidemia have been limited to obese participants but few data are available for the non-obese adults of this study population. This study examined the associations between atherogenic and obesity indices among non-obese adults of Samaru, a suburb of Zaria in Kaduna state, Nigeria. The study protocol was duly approved...

Author(s): Sharaye, K.O.

November 2014

Attenuation of allergic airways inflammation by an extract of Hymenocardia acida

Tracheal hyperresponsiveness, airway mucus production and bronchoalveolar inflammation are the major components of asthma. Here, we aim to investigate the role in the control of asthma of a bioactive plant extracted from Hymenocardia acida in a physiological and pathophysiological model. The effect of H. acida crude extract (HACE) on total cellular components of bronchoalveolar (BAL) fluids was performed on ovalbumin...

Author(s): Fatou Bintou Sar, Mamadou Sarr, Mama S.Y. Diallo, Saliou Ngom, Lamine Gueye, Abdoulaye Samb, Ramaroson  Andriantsitohaina and Annelise Lobstein  

August 2014

Protective effect of ghrelin on paracetamol induced acute hepatotoxicity in rats

In this study we investigated if ghrelin plays a protective role against paracetamol-induced acute hepatotoxicity in rats and the possible mechanism of action. Forty adult male albino rats were divided into four equal groups; control, ghrelin, paracetamol and ghrelin plus paracetamol. Evaluations were made for lipid peroxidation, enzyme activities and biochemical parameters. Liver histopathology was also performed....

Author(s): Ahmed K. Alantary, Mohamad Y. Rezk and Khaled E.A. Soliman

May 2014

Evaluation of the height of premenopausal and postmenopausal women in Zaria, Nigeria

Excessive height loss in postmenopausal women (PMW) has been found to reflect low bone mass; an index helpful in predicting vertebral fractures. One hundred and sixty five women were recruited for the cross-sectional study comprising of 77 premenopausal women who served as control and 88 PMW who constituted the study group. The subjects were administered a questionnaire after obtaining informed consent. While their...

Author(s): Achie, L. N., Olorunshola, K. V. and Mabrouk, M.

December 2013

Neurotoxicity of arsenite (As III): In vitro electrophysiological approach to studying neural activity in rat brain slices

Arsenite (Arsenic III) is ubiquitous and a widely distributed environmental toxin implicated in the aetiology of several neurological disorders. It is found in sea food, chemicals and pesticides. As(III) is also a mitochondria poison that induces reactive oxygen species (ROS) formation and membrane distortion. This study is aimed at proposing an in vitro method to detecting neural activity in rat’s brain treated...

Author(s): Ajonijebu Duyilemi Chris, Ogundele Olalekan Michael, Omoaghe Adams Olalekan, Fabiyi Temitope Deborah and Ojo Abiodun Ayodele

December 2013

Cardio protective effects of Nigella sativa oil on lead induced cardio toxicity: Anti inflammatory and antioxidant mechanism

The present study aimed to evaluate cardio-protective effect of Nigella sativa oil (NSO) on lead induced cardio toxicity. Forty five albino adult rats were randomly divided into 3 groups: control lead (Pb) group that received lead acetate (20 mg/kg/day) 3 times weekly for 8 weeks and PB + NSO group (rats pretreated with Nigella sativa oil (4 ml/kg) orally for 1 h before administration of lead acetate (given as in Pb...

Author(s): Marwa A. Ahmed and Khaled M. A. Hassanein

September 2013

The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus

The aim of this paper is to review the information on type 1 and type 2 diabetes with emphasis on its etiology, pathogenesis and pathophysiology via literature review. Diabetes is a group of metabolic disorders characterized by a chronic hyperglycemic condition resulting from defects in insulin secretion, insulin action or both. Type 1 diabetes is the result of an autoimmune reaction to proteins of the islets cells of...

Author(s): Ozougwu, J. C., Obimba, K. C., Belonwu, C. D., and Unakalamba, C. B.

September 2013

Knowledge of computer vision syndrome among computer users in the workplace in Abuja, Nigeria

Quantitative, descriptive, cross-sectional study was conducted to determine the level of knowledge and extent of computer vision syndrome (CVS) among computer users at the Securities and Exchange Commission (SEC), Abuja, Nigeria. Structured questionnaire was administered to 100 computer users aged between 18 and 40 years. The findings showed that 40% of the participants were aware of CVS; of which 27% had knowledge of...

Author(s): T. R. Akinbinu and Y. J. Mashalla

April 2013

High-sensitivity C-reactive protein a surrogate marker of insulin resistance

  High-sensitivity C-reactive protein (hsCRP) is predictor of cardiovascular disease (heart attack, stroke) in apparently healthy individuals (Pfützner et al., 2004). Very few studies have specifically evaluated the usefulness of hsCRP as a marker of insulin resistance in normoglycemic young adults. The aim of this study was to assess whether hsCRP can be used to detect insulin resistance in normoglycemic...

Author(s): B. L. Preethi, K. M. Prasanna Kumar, G. Jaisri, and K.P. Suresh

  • Article Number: F9DD810623

April 2013

Differential inhibition of agonists-induced tracheal contraction after in vitro enriched-extracts treatment

  In our previous studies, pharmacological actions of Senegalese plants on the modulation of tracheal contractile responses induced by acetylcholine were demonstrated. Here, we aim to demonstrate whether the pharmacological effects previously observed, could be obtained with other contractile agonists, such as histamine and potassium chloride (KCI), in the isolated trachea after treatment with the same...

Author(s): Mamadou Sarr, Fatou B. Sar, Saliou Ngom, Alassane Wele, Lamine Guèye, Fallou Cissé, Abdoulaye Samb, and Annelise Lobstein

  • Article Number: BE6A5E2628

March 2013

A research analysis on blood component usage and wastage in blood bank and blood component center

    A comparative analysis of blood component usage and wastage was performed in the Nukem Blood Bank and Rotary Suzlon Blood Component Center, Haria L. G. Rotary Hospital (Vapi) during 2007 and 2008. Reasons for wastage of blood components and trends for reducing blood component wastage...

Author(s): Manmohan Singhal, Manish Patel, Devesh Kapoor and Dalal Mittal

  • Article Number: 1C78FC1616

March 2013

Changes in haematological parameters of children aged 5 to 18 years in Abidjan, Côte d’Ivoire

  The Millennium Development Goals include an aspect of children's health. The main purpose of this study was to indicate possible changes in different blood cells on one hand and secondly to establish standards of various parameters of the counts in the blood. The study involved 1,157 children aged 5 to 18 years in four selected municipalities of Abidjan. Blood sampling was done fasting in the morning,...

Author(s): Mathieu Nahounou Bleyere, André Brou Konan, Augustin Kouao Amonkan, Hélène Delisle, Duni Sawadogo, Jacques Yao Datte and Paul Angoué Yapo

  • Article Number: 33011B8612

February 2013

Effect of yogic exercise on respiratory system in middle aged men

  The aim of this paper is to study the effect of yogic exercise on respiratory system in middle aged men. The objective of the study is to assess respiratory parameter in both groups. For the study, we selected 90 healthy volunteers between age group 35 to 50. They were divided into 2 groups: 1) control group (45); and 2) study group (yoga) (45). Control group did not perform any exercise or yoga during 6...

Author(s): Kadu P. P and Deshpande V. K

  • Article Number: A4075AB598

February 2013

Matrix metalloproteinases 2 and 9 reduce epithelial sodium channel (ENaC) activity at pleural mesothelium

  The aim of the study was to investigate if Matrix metalloproteinase 2 (MMP2) and Matrix metalloproteinase 9 (MMP9) influence epithelial sodium channel (ENaC) current. Pleural membranes from sheep were mounted at Ussing chambers and were voltage-clamped. MMP2 and MMP9 were applied apically to the pleural membranes and amiloride was added to all experiments. All values are expressed as mean ± standard...

Author(s): Eleni Apostolidou, Konstantinos I. Gourgoulianis, Paschalis-Adam Molyvdas and Chrissi Hatzoglou

  • Article Number: 94C7101604

September 2012

Apoptosis: Current therapeutic approach in retinitis pigmentosa

  Apoptosis is a genetically programmed mechanism of cell death in which the cell activates a specific set of instructions that lead to the deconstruction of the cell from within. Retinitis pigmentosa (RP) represents a group of hereditary retinal degenerations principally characterized by progressive rod-dominant photoreceptor degeneration in the initial stage and eventual cone photoreceptor degeneration in...

Author(s): Marianne L. Shahsuvaryan

  • Article Number: 392C546569

May 2012

Benign cystadenofibroma of the fallopian tube: A case report

  Neoplasms of the fallopian tube are the rarest site for tumors in the female genital tract. Cystadenofibromas of the fallopian tube are rare tumors of the female genital tract with only 15 cases reported worldwide. These tumors are usually asymptomatic and are found incidentally. We are reporting a case of serous cystadenofibroma in a 20 year old woman who underwent emergency LSCS with bilateral tube...

Author(s): Abhishant Pandey, Nandini N. M, Anupam Sarkar, Rajiv Tangri and Shilajit Bhattacharya

  • Article Number: 6C21760570

March 2012

The study of 24 h post treatment effects of the aqueous extract of Rosmarinus officinalis after renal ischemia/reperfusion in rat

  Ischemia/reperfusion (I/R) induced acute renal failure (ARF), causes renal functional and histological disorders. This study investigated the effect of oral Rosemary extract on ARF disorders in rat. Forty male Sprague-Dawley rats were used in 4 groups (n=10) as control, sham, I/R with gavage feeding normal saline, and I/R with gavage feeding of 8% aqueous extract of Rosemary (10 ml/kg/day). ARF was induced by...

Author(s): Marzieh Zohrabi, Saeed Changizi Ashtiyani, Saeed Hajihashemi, Akbar Hassanpoor and Nasser Hosseini

  • Article Number: 3336A20566

March 2012

Study of susceptibility to oral submucous fibrosis (OSF) in the population of West Bengal at XRCC 1 (Arg399Gln) by RFLP

  Oral submucous fibrosis (OSF) is a chronic insidious disease characterized by irreversible generalized fibrosis of the oral soft tissues. It is a debilitating disease of the oral cavity characterized by inflammation and progressive fibrosis of the sub mucosal tissues (lamina propria and deeper connective tissues). It results in marked rigidity and an eventual inability to open the mouth. 10% of the cases...

Author(s): Mousumi Saha, Agniswar Sarkar and Bidyut Bandyopadhyay

  • Article Number: BCC7EA0568

January 2012

Developmental biology in Holy Quran

  Developmental biology such as human reproduction and development are scattered throughout the Qur'an. It is only recently that the scientific meaning of some of these verses has been appreciated fully. The long delay in interpreting these verses correctly resulted mainly from inaccurate translations and commentaries and from a lack of awareness of scientific knowledge. In the Holy Qur'an, God speaks...

Author(s): Esmailzadeh Mahdi, Farhadi Abolfazl, and Shahghasemi Hamid

  • Article Number: 0FC7DEB561

January 2012

Content validity of first M.B.B.S physiology examinations and it’s comparison with teaching hours devoted for different sub-divisions of physiology

  Scientific studies confirm that it is the evaluation system rather than educational objectives, curriculum or instructional techniques that have the most profound impact on students learning. The present study was done to find out the coverage of different sub-divisions of physiology in written examination and its comparison with the teaching hours devoted to the teaching of each topic. For the analyses of...

Author(s): Raghuveer Choudhary, Dr Vinod Kumar Chawla, Kamla Choudhary, Sonika Choudhary and Urmila Choudhary

  • Article Number: A38DD00563

October 2011

Apoptosis: Current therapeutic approach in retinitis pigmentosa

  Apoptosis is a genetically programmed mechanism of cell death in which the cell activates a specific set of instructions that lead to the deconstruction of the cell from within. Retinitis pigmentosa (RP) represents a group of hereditary retinal degenerations principally characterized by progressive rod-dominant photoreceptor degeneration in the initial stage and eventual cone photoreceptor degeneration in...

Author(s): Marianne L. Shahsuvaryan

  • Article Number: D6D1178652

October 2011

Comparative evaluation of serum soluble endoglin level in preeclampsia and normotensive pregnant women

  This study was conducted to evaluate the serum soluble endoglin (CD105) levels in preeclamptic and normotensive pregnant women after 22 weeks of pregnancy. One hundred pregnant women from 22 weeks of gestation till term were divided into 2 groups in this case control study. Group I included 50 women with features of preeclampsia while Group II had 50 gestationally matched normotensive controls. Soluble...

Author(s): Nirmala Duhan, Damayanti Sharma, Neena Garg, Krishna Dahiya and Daya Sirohiwal

  • Article Number: 9D156B8653

July 2011

Effect of different sitting posture on pulmonary function in students

  The purpose of this study was to investigate changes that occur in pulmonary function when postural changes in the sagittal plane are made in a seated position in students. This cross sectional analytical study was done randomly on 20 boys from Iran, and the results of a forced expiratory manouvre in these young healthy subjects were compared according to body posture. Twenty able-bodied...

Author(s): Baghery Hojat and Esmaeilzadeh Mahdi

  • Article Number: 15181A5647

July 2011

Ultraviolet B radiation (UV-B) and the growth and skeletal development of the Amazonian milk frog (Trachycephalus resinifictrix) from metamorphosis

  In captivity some anurans can show poor growth and skeletal development due to inadequate levels of UV-B radiation. From metamorphosis for 84 days the growth and skeletal development of Amazonian milk frogs (Trachycephalus resinifictrix) were assessed between treatments receiving daily UV-B (UV/daily), intense UV-B for 30 min every two weeks (UV/boost), or no UV-B (control). At 14 day intervals snout-urostyle...

Author(s):   Elfi Verschooren, Robert K. Brown, Francis Vercammen  and Jeffrey Pereboom,

  • Article Number: 8F0AF6B649

May 2011

Arabidopsis thaliana thylakoid lumen 18.3 protein gene is up-regulated during dehydration

Selaginella tarmariscina is a resurrection plant and we have cloned several genes for dehydration in S. tarmariscina through differential display. One of the gene (DQ471954) which has 68% homology with Arabidopsis thaliana thylakoid lumen 18.3 kDa protein (TLP18.3) gene. This gene has a domain of unknown function (DUF477) which is a family of uncharacterized protein. The expression...

Author(s): Mohammad Israil Ansari, and Tsan-Piao Lin

  • Article Number: 2D008AD643

May 2011

Respiratory physiology training in Tanzania: Need to focus on primary respiratory care

  Effective management of Chronic obstructive pulmonary disease (COPD) by General Practitioners is likely to be compromised by respiratory physiology training that has main focus on acute respiratory diseases with high mortality and little focus on empowering medical and nursing students and practitioners on respiratory care. Results of this study indicate that lack of responsiveness of respiratory physiology...

Author(s): Yohana Mashalla, Amos Massele, Marina Njelekela and Simon Mamuya

  • Article Number: 4C973A4644

February 2011

Frequency of celiac disease in Egyptian patients with chronic diarrhea: Endoscopic, histopathologic and immunologic evaluation

  Chronic diarrhea is one of the major presenting features of celiac disease (CD), the frequency of CD in patients with chronic diarrhea in Egypt remains unknown. The aim of this study is to determine the frequency of CD among Egyptian patients with chronic diarrhea. This study included 113 adult patients with chronic non-bloody diarrhea that attended the Tropical Medicine and Gastroenterology Department,...

Author(s): Ahmed Medhat, Nadia Abd El Salam, Sahar M. Hassany, Howida I. Hussein and Hubert E. Blum

  • Article Number: 48908D5637

February 2011

Renal ischemia /reperfusion injury in type II DM: Possible role of proinflammatory cytokines, apoptosis, and nitric oxide

  Diabetes mellitus (DM) especially type II is a major health problem and diabetic nephropathy is the main cause of end stage renal disease (ESRD). Renal ischemia/reperfusion (I/R) injury is common in diabetic patients. Recent studies reported increased vulnerability of kidney to I/R injury in diabetic rats. Mechanisms behind this increased vulnerability not fully understood. The present study...

Author(s): Mahmoud M. Gabr, Abdel-Aziz M. Hussein, Iman O. Sherif, Sousou I. Aliand Hoda E. Mohamed

  • Article Number: A154C14639

November 2010

Mosquitocidal bacterial toxins (Bacillus sphaericus and B. thuringiensis serovar israelensis): Mode of action, cytopathological effects and mechanism of resistance

  Bacillus sphaericus Neide (Bs) and Bacillus thuringiensis serovar israelensisdeBarjac (Bti) provide effective alternatives to broad spectrum larvicides in many situations with little or no environmental impact. Taking into account environmental benefits including safety for humans and other non-target organisms, reduction of pesticide residues in the aquatic environment,...

Author(s): Subbiah Poopathi and S. Abidha

  • Article Number: ED79882634

November 2010

Serum testosterone and morphology of the testes in wistar rats following chronic garlic feeding

  Garlic (Allium sativum) is a popular spice usually eaten raw or cooked in various doses and its potential medical properties have been recognized for thousands of years (Agarwal, 1996). Testosterone is a steroid hormone from the androgen group. 21 adult male wistar albino rats were randomly divided into control, test 1 and test 2 groups. The test 1and test 2 groups received oral doses of 1.4 and 2.4 ml...

Author(s): Ebomoyi, Maureen Isoken and Ahumibe, Kennedy Chijioke

  • Article Number: 81CBD73636

August 2010

HMG CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase inhibitors: Evaluation of the role and actions in age-related macular degeneration

  Age-related macular degeneration (ARM) is a progressive late onset disease affecting central vision. It is the leading cause of irreversible blindness among older adults in developed countries, and with the aging population, the problem is increasing. Current treatment options by endothelial growth factor (VEGF) inhibitors – anti-VEGF therapy are limited to the late stage of the disease, when central...

Author(s): Marianne Shahsuvaryan

  • Article Number: 388DA3B630

August 2010

Effect of Ipomoea batatas leaf extract on the thyroid-gonadal axis of male Wistar rats

  The effect of the leaf extract Ipomoea batatas was investigated on the thyroid gonadal axis of male rats. The leaf extract of I. batatas was extracted by dissolving a measured dry-powder leaf sample in a known volume of distilled water. The soaked plant sample was allowed to stand overnight for 24 h. The sample was filtered and the filtrate evaporated into solid extract. Three doses of the...

Author(s): P. B. Udoh, F. V. Udoh, I. S. Umo and E. V. Ikpeme

  • Article Number: B91EC8B633

April 2010

Anti-plasmodial and toxicological effects of methanolic bark extract of Chrysophyllum albidum in albino mice

  The anti-plasmodial, hematological, serum biochemical and pathological effects ofChrysophyllum albidum methanolic bark extract were evaluated using Swiss albino male mice as models. The plant is used in Southern Nigeria as a remedy for malaria and yellow fever. The LD50 of the methanolic extract was 1850 mg/kg body weight. C. albidum methanolic bark extract (750 - 1500 mg/kg/day) exhibited...

Author(s): E. O. Adewoye, A. T. Salami and V. O. Taiwo

  • Article Number: 5987CCC624

April 2010

The impact of viva-voce examination on students’ performance in theory component of the final summative examination in physiology

  Viva voce examinations formed a part of theory component of final summative examination. Since viva voce was conducted to all students irrespective of their passing status in theory, the exercise was found to be time consuming. In this perspective, this study was conducted to determine the impact of viva voce examination on student performance in the summative examination. Three batches of first year medical...

Author(s): Sharmila Torke, Reem Rachel Abraham, K. Ramnarayan and K. Asha

  • Article Number: 28C4ED1626

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