Abbreviation: J. Comput. Biol. Bioinform. Res
Start Year: 2009
Page 1 of 2, showing 20 records out of 33 total, starting on record 1, ending on 20
DOI: 10.5897/JCBBR2013.082[Article Number: 573BB7D52788]
TaHSC70 gene of Triticum sp. is an associate of the heat shock protein family and plays a significant role in stress-related and defense responses educed by contagion with stripe rust fungus through a Jasmonic acid dependent signal transduction pathway. Hence, understanding molecular structure and function of the protein coded by this gene is of paramount importance for plant biologists working on stripe rust. The... Read more.
DOI: 10.5897/JCBBR2014.0102[Article Number: 60FC53E48559]
Single nucleotide polymorphisms (SNPs) represent an important type of dynamic sites within the human genome. These common variants often locally correlate within more complex multi-SNP haploblocks that are maintained throughout generations in a stable population. Information encoded in the structure of SNPs and SNP haploblock variation can be characterized through a normalized information content metric. Genodynamics is... Read more.
DOI: 10.5897/JCBBR10.011[Article Number: FF035ED9875]
Protein-protein interactions are playing a fundamental role in different cellular activities. Although the coevolution of interacting protein pairs has been established by several groups, whether a protein having multiple interacting partners coevolves with all of its interacting partners or not have not been studied, so far. Here, the coevolution of proliferating cell nuclear antigen (PCNA) with their multiple... Read more.
DOI: 10.5897/JCBBR12.012[Article Number: 381F7A49804]
The MLH1 gene responsible for colon cancer has been examined to identify functional consequences of single-nucleotide polymorphisms (SNPs). 16 SNPs have been identified in the MLH1 gene in which all are found to be nonsynonymous. Non synymous SNPs are relevant in many of the human inherited diseases since they change the aminoacid sequence of the protein. 56% of the identified nsSNPs have been reported as damaging. In... Read more.
DOI: 10.5897/JCBBR12.013[Article Number: 19EC4499816]
Scientific efforts in the eradication of neglected tropical diseases, such as those caused by the parasitic helminthes, can be improved if a database of key virulence factors directly implicated in pathogenesis is available. As a first step towards creating SchistoVir, a database of virulence protein factors in schistosomes, in this study, we curated, annotated and aligned sequences of twenty virulence factors... Read more.
DOI: 10.5897/JCBBR11.014[Article Number: 79C67CA9725]
The major objectives of this study were to identify spectral characteristics associated with rice yield and to establish their quantitative relationships. Field experiments were conducted at Shi-Ko experimental farm of TARI’s Chiayi Station, during 2001 to 2005. Rice cultivar Tainung 67 (Oryza sativa L.), the major cultivar grown in Taiwan, was used in the study. Various levels of rice yield were obtained via... Read more.
DOI: 10.5897/JCBBR12.005[Article Number: DCF2A719741]
Beta endorphin is a neurotransmitter and is involved in functions like enhancement of immune system, deceleration of cancer cell growth and induction of euphoria and relaxation. It is an opioid like neuropeptide synthesized in neurons of hypothalamus and pituitary gland. The study of its structure and its interaction with opioid receptors can throw light on its neuropsychopharmacology. Protein data bank does not contain... Read more.
DOI: 10.5897/JCBBR11.030[Article Number: 482A12E9687]
The stability of protein-ligand complex is decided by the strength of the forces and interaction that holds the overall structure. The binding of ligand to its receptor involves the participation of atomic interactions of key conserved amino acid residues which are essential for functional and structural integrity of protein molecule. Understanding the binding mechanism of ligand to its receptors is important in... Read more.
DOI: 10.5897/JCBBR12.001[Article Number: 9270C189703]
The role of DmsD in the biosynthesis of dimethyl sulfoxide (DMSO) reductase is quite controversial. Several studies have indicated its role as ‘proof-reading chaperone’, which might function to prevent the translocation of misfolded and non-cofactor containing protein. DmsD is also shown to bind to the signal peptide; however, its possible function as a ‘guidance factor’ for membrane targeting is... Read more.
DOI: 10.5897/JCBBR11.026[Article Number: 193028A9645]
The 21st century emergence of genomic medicine is shifting the paradigm in biomedical science from the population phenotype to the individual genotype. In characterizing the biology of disease and health disparities in population genetics, human populations are often defined by the most common alleles in the group. This definition poses difficulties when categorizing individuals in the population who do not have... Read more.
DOI: 10.5897/JCBBR11.028[Article Number: F08BEBB9658]
Approximately 3 billion people, one half of the world’s population, live in at-risk regions for malaria infection leading to about 250 million malaria cases every year and nearly one million deaths. Once the malarial parasite Plasmodium vivax and Plasmodium falciparum enters the red blood cells its growth is inhibited by Proguanil, a prophylactic antimalarial drug which inhibits the... Read more.
DOI: 10.5897/JCBBR11.017[Article Number: 43A57009607]
HIV integrase is a 32 kDa protein produced from the C-terminal portion of the Pol gene product, and is an attractive target for new anti-HIV drugs. Its main function is to insert the viral DNA into the host chromosomal DNA, a step that is essential for its replication. However there are six different Protein Data Bank (PDB) entries of the same protein with the same amino acids with PDB IDs 1BIS, 1BIU, 1BIZ, 1HYV, 1HYZ... Read more.
DOI: 10.5897/JCBBR11.015[Article Number: 69C54649623]
Paraoxonases are a group of enzymes involved in the hydrolysis of organophosphates. Human Paraoxonase 1 is synthesized in liver and secreted into blood, where it is associated exclusively with High Density Lipoproteins and may protect against the development of atherosclerosis. Paraoxonase was identified as a genetic risk factor for cardiovascular disease. An enhancement of Paraoxonase 1 activity by well-known anti... Read more.
[Article Number: D44EA679088]
Zinc fingers are the most abundant eukaryotic DNA-binding motifs, which recognize DNA triplets with high efficacy and are used to develop chimeric enzymes for genome modification and site specific gene therapy. Considering the importance of zinc finger motifs and their recognition patterns we have developed a web interface with the incorporation of sequence based search algorithm named as Bind-Predict. This algorithm... Read more.
[Article Number: 93693009115]
To understand the types of mitochondrial deoxyribonucleic acid (mtDNA) pseudogenes in the genome of the silkworm Bombyx mori L. (Lepidoptera: Bombycidae) and to determine the origin of the B. mori, the mtDNA of the wild silkworm, Bombyx mandarina Morre was sequenced. Several fragments from the B. mori genome database were obtained with varying degrees of homology toB.... Read more.
[Article Number: E61348B40212]
Gene sequence analysis is a key-step for genomic research, which help to understand the genome of species once it has been sequenced. It includes pair-wise, comparative or multiple sequence analysis. The Genome On-Line Database (GOLD) provides information about the number of completed, meta, incomplete and targeted genome projects. The statistics of GOLD show 2942 of completed, 7687 of incomplete, 340 of meta... Read more.
[Article Number: 18B2B3740212]
In order to reduce the amount of information when querying from large databases, one has to develop new approaches. We present here a new way to query our SQUAT database. SQUAT contains formal concepts representing an association between a number of genes that are simultaneously over expressed and the biological situations in which those genes are over expressed. We explored the relevance of querying... Read more.
[Article Number: 9BA2E578999]
Developing models that can represent biochemical systems is one of the hallmarks of systems biology. Scientists have been gathering data from actual experiments, but there is a lack in computer models that can be used by scientists in analysing the various biochemical systems more effectively. In this research, we propose to use an ant colony optimization (ACO) algorithm for the network inference and parameter... Read more.
[Article Number: 4D423029010]
In this short communication we consider the recent results of the successful substitution of theEscherichia coli RNase P ribonucleic acid (RNA) with the Arabidopsis protein enzyme PRORP1. The interest of this result lies in the fact that a plant protein-only enzyme is able to rescue lethal knock-down of the RNA component of bacterial RNase P. Such findings raise interesting questions as well as... Read more.
[Article Number: 7F5FF809000]
This paper outlines two hybrid approaches to investigate the nonlinear relationship between size of a forest fire and meteorological variables (temperature, relative humidity, wind speed and rainfall). Self organizing map was used to cluster the historical meteorological variables. The clustered data were then used as inputs for two different approaches, the back-propagation neural network and the rule generation... Read more.
Page 1 of 2, showing 20 records out of 33 total, starting on record 1, ending on 20