Abbreviation: J. Bioinform. Seq. Anal.
Start Year: 2009
Page 1 of 3, showing 20 records out of 41 total, starting on record 1, ending on 20
DOI: 10.5897/JBSA2015.0101[Article Number: FECF9C959898]
β-galactosidase (EC.22.214.171.124) is an important enzyme, mainly used in the preparation of lactose hydrolyzed milk suitable for people with lactose intolerance. It is essential to understand the structural and functional aspects of various β-galactosidase produced from different sources. The present work deals with the use of bioinformatics to describe the physiochemical, functional and structural properties of... Read more.
DOI: 10.5897/JBSA2011.021[Article Number: 398802849921]
The most conserved regions for 15 hepatitis B virus complete genome of different subtypes were aligned using PCGENE software CLUSTAL to design a new pair of primer that can bind to each subtype of hepatitis B virus (HBV), to amplify PreS region of HBV genome. A pair of primer from these conserved patches was selected using software PRIMER and named as Nhepf1 and Nhepr1. Nhepf1, forward primer bound 2362-2385 nucleotides... Read more.
DOI: 10.5897/IJBC2013.0086[Article Number: 093849744377]
Following advances in DNA and protein sequencing, the application of computational approaches in analysing biological data has become a very important aspect of biology. Evaluating similarities between biological sequences is crucial to our understanding of evolutionary biology, and this can be achieved by basic local alignment search tool (BLAST) and fast alignment (FASTA). BLAST and FASTA have become fundamental tools... Read more.
[Article Number: 8D78AD72406]
Ljubljana can be observed through different perspectives. Urban development is often written on the basis of economic level, social development, benchmarking results with similar economies, on the basis of past experiences. By urbanistic way of life we cover the main Slovenian areas in polycentric net, that is well organised in EU space. City is forced to lead a vital, beautiful and clean environment that supports... Read more.
DOI: 10.5897/JBSA11.023[Article Number: FE6EE595768]
The identification of major histocompatibility complex (MHC) class-II restricted peptides is an important goal in human immunological research leading to peptide based vaccine designing. These MHC class II peptides are predominantly recognized by CD4+ T-helper cells, which when turned on, have profound immune regulatory effects. Thus, prediction of such MHC class-II binding peptide is very helpful towards... Read more.
DOI: 10.5897/JBSA2012.0056[Article Number: 0943E915791]
MicroRNA is a family of small non-coding RNAs that regulate gene expression in a sequence-specific manner. miRNAs are a class of post-transcriptional regulators. miRNAs are a family of 19 to 25 small nucleotide RNAs. Since miRNAs have been discovered and their role in gene regulation established, it has been theorized that viruses could generate miRNAs as well and that these viral encoded miRNAs could... Read more.
DOI: 10.5897/JBSA10.015[Article Number: 11EB0155724]
The realization regarding the significance of microorganisms is increasing with the passage of time. In today’s scenario of global climate change and increasing threats to biodiversity, the wheel of advanced biotechnologies is revolving around microbes to restore the ecological balance lost in the past few decades. In Pakistan, however, we lack sufficiently reliable biological data to start with and our... Read more.
DOI: 10.5897/JBSA11.022[Article Number: E93F45E5736]
Three-dimensional (3D) protein structures provide helpful insights into the molecularassociation of a gene, its purpose also allow efficient drug designing experiments, such as the structure-based design of specific inhibitors. Recently, it has been shown that protein (cereblon) is involved in various tissues and brain and is revealed to be related with mental retardation. After this first report of cereblon... Read more.
DOI: 10.5897/JBSA12.001[Article Number: 949B2105635]
The metabolic changes in serum during a sport program were explored using a metabonomic approach, based on proton nuclear magnetic resonance (1H-NMR) spectroscopy and anthropometry. The aim of this study was to classify two groups of female university students with body mass index over 25 kg/m², using multiple measured descriptors. The first group (n=16) underwent a complex and well programmed 18-week physical... Read more.
DOI: 10.5897/JBSA11.012[Article Number: 7C15E975645]
Due to the difficulty in obtaining a 24 h urine collection in children, a random sample of urine is often used to calculate the urine calcium to creatinine ratio. Also, urinary calcium excretion might be influenced by genetic, geographic area, etc. we decided to evaluate the urinary calcium, creatinine, sodium and potassium excretion in healthy children with 1-7 years and determine age-related reference... Read more.
[Article Number: 58C31EF5603]
The proposed Neural-Fuzzy pattern recognition (NFPR) system discussed in this paper effectively reduces the complication in precisely analyzing and interpreting human deoxyribonucleic acid (DNA) sample. In this novel approach, the perfect blend made of bioinformatics and a competitive method of neural networks technique, which has the advantage over conventional computation technique, in... Read more.
[Article Number: 548C10C5618]
Computational analysis of amino acid sequences of aliphatic amidases and kynurenine formamidases for some of their physiochemical properties and their substrate specificity has been done. Multiple sequence alignment of 18 amino acid sequences shows a clear difference between the two classes of aminohydrolases. Statistical analysis indicated a clear distinction between aliphatic amidases... Read more.
[Article Number: 6368F575575]
Drug discovery process is a critical issue in the pharmaceutical industry since it is a very cost-effective and time consuming process to produce new drug potentials and enlarge the scope of diseases incurred. Drug target identification, being the first phase in drug discovery is becoming an overly time consuming process. In many cases, such produces inefficient results due to failure of conventional... Read more.
[Article Number: 2F36E845584]
DOI: 10.5897/JBSA09.017[Article Number: 92AA51B3155]
Most positions of the human genome are typically invariant (99%) and only some positions (1%) are commonly invariant which are associated with complex genetic diseases. Haplotype information has become increasingly important in analyzing fine-scale molecular genetics data, due to the mutated form in human genome. Haplotype assembly is to divide aligned single nucleotide polymorphism (SNP) fragments, which is... Read more.
DOI: 10.5897/JBSA11.003[Article Number: F4E553C3169]
Overwintering plants produce antifreeze proteins (AFPs) which permits the plant survival in cold condition. Analysis of sequence and structural features of these proteins would help in better understanding of their functions. In this study, we report the analysis of 40 plant AFPs on the basis of sequence and structural based classification scheme (CS). Sequence based CS segregates the AFPs into various... Read more.
[Article Number: F8BC82B3076]
Oxidosqualene cyclase (OSC) or Lanostrol Synthase is one of the major enzyme in cholesterol biosynthesis. OSC is involved in conversion of squalene to lanosterol. Increased level of cholesterol in blood leads to hypercholesterolemia and major risk factor for cardiovascular diseases. Statin drug molecule is developed to inhibit HMGCoA, which is the first enzyme of cholesterol biosynthesis showed major side... Read more.
[Article Number: F832BAB3106]
Gene expression at the level of transcription is regulated by a set of transcription factors (TFs) that recognizes cis elements. We accessed the human promoters from eukaryotic promoter database. These sequences have been run in P-match tool. MEME software has been used for detection of conserved sequences in the promoter region. All the predicted known TFs and their binding sites along with weight... Read more.
[Article Number: DAFA6BF3025]
Avian influenza virus is a major cause of influenza all over the world. Influenza virus being a RNA virus shows high mutation rates, antigenic shift and drift. These phenomena contribute to ineffective chemotherapy against influenza viruses. Recent advances in the current therapy, drugs and vaccines are restricted with many factors such as toxicity, complexity, cost and resistance. New technologies... Read more.
[Article Number: 6D761403038]
Using different cassava maturity age of 9, 12 and 15 months, evaluation study was carried out on cassava mash dewatering methods. Dewatering tanks with square and cylindrical shapes were made with steel for the experiment. Pressure devices from screw bolts, hydraulic jack press and rope / stick methods were used to squeezed cassava juice from the mash in the tanks. TMS 4(2) 1425 variety of cassava was used.... Read more.
Page 1 of 3, showing 20 records out of 41 total, starting on record 1, ending on 20