Abbreviation: Afr. J. Pharm. Pharmacol.
Start Year: 2007
Page 1 of 99, showing 20 records out of 1965 total, starting on record 1, ending on 20
DOI: 10.5897/AJPP2016.4648[Article Number: 3D22B2861181]
This study investigated the antioxidant and anti-inflammatory effects from the inner bark of Mimosa tenuiflora. The hydroethanol extract (HEE) and its hexane (HXF), chloroform (CLF), ethyl acetate (EAF) and hydromethanol (HMF) fractions were prepared and submitted to phytochemical screening and antioxidant activity. In vivo anti-inflammatory effect was investigated by using 12-O-tetradecanoylphorbol 13-acetate... Read more.
DOI: 10.5897/AJPP2015.4454[Article Number: 3CDA35961189]
Croton macrostachyus leaves are used for treatment of wounds by traditional healers in Ethiopia. Despite the use of this plant in the treatment of wound, there is limited data to support its medicinal use. The present study provides scientific evaluation for the wound healing potential of methanolic extract of C. macrostachyus leaves in rats. The leaves of Croton macrostachyus were studied for the presence of some... Read more.
DOI: 10.5897/AJPP2016.4667[Article Number: D438F8E61193]
This study investigated the effectiveness of the Mobile Authentication Service (MAS) introduced on antimalarial medicines (AMs) in curbing the incidences of counterfeiting for this group of pharmaceuticals. The assessment of the knowledge, attitude and use of the technology by Nigerian citizens, uncovering areas of deficit as well as proffering recommendations on the current use pattern of MAS by Nigerians was carried... Read more.
DOI: 10.5897/AJPP2016.4556[Article Number: 7961D5061123]
There is an alarming rise in treatment failures from artemisinin combination therapy (ACT). The aim of this study was to access the therapeutic effectiveness of ACT in the market and the rate of re-occurrence of malaria shortly after completion of therapy. The rate of adherence to therapy and relapse rate of four hundred volunteers, who recently treated malaria, were assessed using quantitative interview-semi structured... Read more.
DOI: 10.5897/AJPP2016.4673[Article Number: C30DCF961125]
The present investigation was to examine the in vivo antioxidant activity and lipid peroxidation activities of different extracts of aerial parts of Chomelia asiatica (Linn). High fat diet rats demonstrated fundamentally decreased the levels of tissues enzymatic antioxidant and non-enzymatic antioxidant (Glutathione). The level of thiobarbuturic acid reactive substance (TBARS) is reduced in high-fat diet (HFD) rats when... Read more.
DOI: 10.5897/AJPP2016.4605[Article Number: 4C2C53C61129]
Conventional pharmacokinetic profiles of drugs are described mainly by plotting drug plasma concentration versus time. However, topical drugs are designed to target local tissue and, as such, have limited systemic absorption. For these drugs, the pharmacokinetic measurements in the local tissue (skin) are of more importance than systemic measurements. In this context, this study aims to develop and discuss the... Read more.
DOI: 10.5897/AJPP2015.4405[Article Number: 3E988DE60965]
There is a resurgence in the use of herbal medicine in the developed countries, with even much more in low developed Countries and especially for conditions such as erectile dysfunction. Studies thus need to be conducted to scientifically validate claims on certain medicinal plants reported to be efficacious in traditional medicine. This current study was conducted to determine the phytochemical composition and efficacy... Read more.
DOI: 10.5897/AJPP2016.4603[Article Number: 41375DF60982]
In the present investigation, the methanol leaves extract of Podocarpus neriifolius D. Don was assessed for antibacterial and antioxidant activities. The antibacterial action was evaluated through agar disc diffusion method against seven pathogenic and non-pathogenic bacterial strains at various concentrations and compared against the standard (kanamycin 30 µg/disc). The antioxidant activity of the extract was... Read more.
DOI: 10.5897/AJPP2016.4647[Article Number: 841E71E60987]
Wissadula periplocifolia (L.) C. Presl. is a medicinal plant widely distributed in USA, but it has not yet been investigated extensively. Some pharmacochemical studies were performed at the Federal University of Paraiba, and the components of the crude ethanolic extract were identified; one of them was a tiliroside, which has already been shown to have excellent anti-inflammatory activity that can inhibit the... Read more.
DOI: 10.5897/AJPP2016.4671[Article Number: F37A64C60747]
Hydantoins are often reported as potent anticonvulsant drugs; however, recent studies have highlighted their antinociceptive potential. Based on these reports, this study investigated the antinociceptive and anti-inflammatory activities of the hydantoin derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione (IM-7) using animal models. Treated mice submitted to the acetic acid-induced writhing test showed... Read more.
DOI: 10.5897/AJPP2015.4491[Article Number: 2509A5D60752]
Polyphenols (PPH) represent a group of chemical substances found in plants, characterized by the presence of more than one phenol unit. The largest and best studied polyphenols are the flavonoids. Polyphenols contained in red wine have beneficial effects on cardiovascular health. The aim of our research was a comparative and interactive study of four red wine polyphenols - resveratrol (R), quercetin (Q), kaempferol (K)... Read more.
DOI: 10.5897/AJPP2015.4639[Article Number: 9AEB94060756]
Plant products are a rich source of bioactive organic chemicals and offer an advantage over synthetic pesticides as these are less toxic, less prone to development of resistance and easily biodegradable. The present study aimed at screening the acaricidal potential of crude methanolic and aqueous extracts of Schinus molle (L.) leaves on the adult Bophilus decoloratus and Rhipicephalus pulchellus cattle ticks, using in... Read more.
DOI: 10.5897/AJPP2015.4640[Article Number: 4C6F1A960758]
Diets and nutrition have critical effect on immune status of human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) patients and on recovery of immune competence after antiretroviral therapy (ART). A pilot study was conducted to explore associations between the dietary pattern of HIV/AIDS patients and their immune (CD4+ cell recovery) response following ART. A recall interview survey... Read more.
DOI: 10.5897/AJPP2016.4644[Article Number: C55554260691]
A Schiff base and its derivative (oxazepine) have been synthesized by the reaction between thio-semicarbazide and aromatic aldehyde 4-hydroxybenzaldehyde in ethanol in the presence of acetic acids to yield the Schiff base. This Schiff base on treatment with phthalic anhydride to give seven-member heterocyclic ring called oxazepine. Oxazepineas di-dentate ligand treated with hydrated metal chlorides CuCl2 and FeCl2 in... Read more.
DOI: 10.5897/AJPP2016.4575[Article Number: FCE6B2860693]
The highly selective serotonin reuptake inhibitors are successful in the treatment of depression mood and anxiety disorders. The objective of this study is to investigate the effect of fluexotine and buspirone when given orally in three dose levels (5, 10 and 15 mg/ kg) not only for eight weeks on gastric lesions and oxidative markers in normal rats' mucosal integrity, but also for four weeks on gastric mucosal... Read more.
DOI: 10.5897/AJPP2015.4506[Article Number: 51CFFF460696]
Acetazolamide is a carbonic anhydrase inhibitor which is on World Health Organization’s list of essential medicines, a list of most important medications needed in a basic health system. The ocular effects of acetazolamide was studied in 30 normotensive volunteers. Each volunteer received a loading dose of 500 mg at 0700 h followed by a maintenance dose of 250 mg at 1300 and 1800 h, respectively on day one. From... Read more.
DOI: 10.5897/AJPP2016.4655[Article Number: 6675D3560429]
MiR-33a and miR-122 are major regulators of lipid metabolism in the liver and their deregulation has been linked to the development of metabolic diseases such as obesity and metabolic syndrome. The aim of this study was to evaluate whether the level of miR-33a and miR-122 in rat liver correlate with obesity and potential anti-obesity effect of grape seed extract (GSE) and calorie restricted diet with special emphasis on... Read more.
DOI: 10.5897/AJPP2016.4609[Article Number: 897B74660432]
Senna alata is a medicinal plant that belongs to Leguminosae family. Different parts of the plant are used in folklore medicine for curing skin infections, abdominal pain, and gonorrhoea. Despite the use of S. alata in the treatment of various ailments, there is limited or no comprehensive scientific information on the toxicological evaluation of the dried leaf extract in the folklore medicine in Africa. This study... Read more.
DOI: 10.5897/AJPP2016.4581[Article Number: 792A11660435]
Petiveria alliacea L. (Phytolaccaceae) is an Amazonian shrub used in traditional medicine for many purposes. This study investigated the genotoxicity of the hydroalcoholic extract of P. alliacea (EHPa). In addition, we conducted pharmacognostic characterization and phytochemical investigation. Phytochemical screening and thin layer chromatography (TLC) were used to determine the chemical composition of the extract.... Read more.
DOI: 10.5897/AJPP2016.4557[Article Number: 74C34D360405]
The coupling of the derivatives of the 2-mercaptobenzimidazole 1 with the derivatives of the (chloromethyl)benzene 2 gives 2-(benzylthio)benzimidazole 4a-k on the one hand, and with the 2-(chlorométhyl)benzimidazole 3 on the other the 2-(benzimidazolyl methylthio) benzimidazole and analogues 5a-k. We determined the structures of all synthesized compounds by Nuclear Magnetic Resonance (NMR) and Mass Spectrometry... Read more.
Page 1 of 99, showing 20 records out of 1965 total, starting on record 1, ending on 20