Abbreviation: Afr. J. Pharm. Pharmacol.
Start Year: 2007
Page 1 of 99, showing 20 records out of 1975 total, starting on record 1, ending on 20
DOI: 10.5897/AJPP2015.4357[Article Number: 23730ED61820]
Members of the genus Desmodium are widespread in the sub-tropics, tropics and used in traditional medicine, as part of recipes for treating fever, pains, cough and dysentery. In this study, phytochemical screening and comparative anti-inflammatory activities of the methanol extracts, hexane and ethyl acetate fractions of the leaves of Desmodium velutinum and Desmodium scorpiurus were investigated using the... Read more.
DOI: 10.5897/AJPP2016.4675[Article Number: 76C410961824]
The aim of this research was to explore the in vitro antioxidant, antibacterial and anticancer activities of flavonoid rich fraction from the leaves of Enicostemma axillare. The total phenolic and flavonoid contents were assessed by Folin–Ciocalteu and Aluminium chloride method respectively. Antioxidant activities of this plant was confirmed on the source of ABTS (2,2'-azino-bis-3-ethyl... Read more.
DOI: 10.5897/AJPP2016.4636[Article Number: 40840EB61828]
Botulinum toxin type A is one of the most used products in mitigation of wrinkles and expression lines by promoting muscle paralysis. Because of their hydrophilic and high molecular mass, this active has low permeability through the skin. Thus, to exert its action as rejuvenation agent, botulinum toxin needs to be applied through intramuscular injections, causing pain and discomfort to the patient. An alternative to... Read more.
DOI: 10.5897/AJPP2016.4662[Article Number: 4FE928961651]
Research on natural products is facing significant difficulty. The analysis "high-throughput screening" has limited effectiveness in their evaluation. This report on in vitro screening of pharmacological activity of the drugs candidate molecule by evaluating a single target. The presence of many substances in a natural extract makes this process unprecise. The zebrafish (Danio rerio, ZF) is well suited to... Read more.
DOI: 10.5897/AJPP2016.4683[Article Number: DBDB39861653]
The genus, Calliandra is popularly used for renal pain, cystitis, prostate inflammation, fever and toothache. This study aimed at investigating the antinociceptive activity of methanolic crude extract (MCE) of Calliandra umbellifera, regarding chemical (acetic acid, formalin and glutamate tests) of nociception (in vivo) and the methanolic extract and hidrobutanolic phase (HBF) antioxidant activity by the... Read more.
DOI: 10.5897/AJPP2016.4663[Article Number: 97840D161655]
Calophyllum brasiliense (Cb) belongs to the Clusiaceae family and it is generally used for diabetes treatment. The aim of this study was to evaluate the anti-diabetic effect of Cb’s hydroethanolic extract (CBE) on diabetic induced rats by streptozotocin and evaluate the content of polyphenols and tannins of the extract. The polyphenols and tannins evaluation in the extract were determinated by a... Read more.
DOI: 10.5897/AJPP2015.4633[Article Number: 2AED5A561643]
There are many conflicting reports around the phenytoin (PHT)-induced genotoxic effect especially in the in-vitro studies. PHT was claimed to cause genotoxic effect by the oxidative stress of its metabolic intermediates. However, by reviewing the distribution and activity of the enzymes responsible for PHT metabolism, we found that PHT is rarely metabolized by human lymphocytes. So that, we will use isolated cultured... Read more.
DOI: 10.5897/AJPP2015.4493[Article Number: 6122EE561645]
This study determined the therapeutic effect of ethanol leaf extract of Combretum zenkeri on kidney function of rats exposed to benzo[a]pyrene. Male Wistar albino rats were treated with ethanol leaf extract of C. zenkeri (400 mg/kg) in the presence or absence of BaP (200 mg/kg) for four weeks. The blood obtained at the end of the treatment was processed into serum and used for biochemical analyses and kidney... Read more.
DOI: 10.5897/AJPP2015.4423[Article Number: 27DF36B61419]
The present investigation was designed to evaluate the analgesic and central nervous system (CNS) depressant activities of the methanolic extract of Ziziphus rugosa Lam. in rat model. The analgesic activity of the extract was examined using acetic acid-induced writhing test (chemically induced pain) at the doses of 200 and 300 mg/kg body weight. Further, the CNS depressant activity of the plant extract was evaluated by... Read more.
DOI: 10.5897/AJPP2016.4595[Article Number: 44E8CE961421]
Management of rheumatic disorders are limited by the inability to provide long-term drug delivery due to the irritation to gastric mucosa and poor availability of drugs, which may be overcome by prolonging the drug release. The nanostructured carriers (NP)based gel was developed as potential topical system for aceclofenac topical delivery. In the present study, chitosan-sodium alginate... Read more.
DOI: 10.5897/AJPP2016.4648[Article Number: 3D22B2861181]
This study investigated the antioxidant and anti-inflammatory effects from the inner bark of Mimosa tenuiflora. The hydroethanol extract (HEE) and its hexane (HXF), chloroform (CLF), ethyl acetate (EAF) and hydromethanol (HMF) fractions were prepared and submitted to phytochemical screening and antioxidant activity. In vivo anti-inflammatory effect was investigated by using 12-O-tetradecanoylphorbol 13-acetate... Read more.
DOI: 10.5897/AJPP2015.4454[Article Number: 3CDA35961189]
Croton macrostachyus leaves are used for treatment of wounds by traditional healers in Ethiopia. Despite the use of this plant in the treatment of wound, there is limited data to support its medicinal use. The present study provides scientific evaluation for the wound healing potential of methanolic extract of C. macrostachyus leaves in rats. The leaves of Croton macrostachyus were studied for the presence of some... Read more.
DOI: 10.5897/AJPP2016.4667[Article Number: D438F8E61193]
This study investigated the effectiveness of the Mobile Authentication Service (MAS) introduced on antimalarial medicines (AMs) in curbing the incidences of counterfeiting for this group of pharmaceuticals. The assessment of the knowledge, attitude and use of the technology by Nigerian citizens, uncovering areas of deficit as well as proffering recommendations on the current use pattern of MAS by Nigerians was carried... Read more.
DOI: 10.5897/AJPP2016.4556[Article Number: 7961D5061123]
There is an alarming rise in treatment failures from artemisinin combination therapy (ACT). The aim of this study was to access the therapeutic effectiveness of ACT in the market and the rate of re-occurrence of malaria shortly after completion of therapy. The rate of adherence to therapy and relapse rate of four hundred volunteers, who recently treated malaria, were assessed using quantitative interview-semi structured... Read more.
DOI: 10.5897/AJPP2016.4673[Article Number: C30DCF961125]
The present investigation was to examine the in vivo antioxidant activity and lipid peroxidation activities of different extracts of aerial parts of Chomelia asiatica (Linn). High fat diet rats demonstrated fundamentally decreased the levels of tissues enzymatic antioxidant and non-enzymatic antioxidant (Glutathione). The level of thiobarbuturic acid reactive substance (TBARS) is reduced in high-fat diet (HFD) rats when... Read more.
DOI: 10.5897/AJPP2016.4605[Article Number: 4C2C53C61129]
Conventional pharmacokinetic profiles of drugs are described mainly by plotting drug plasma concentration versus time. However, topical drugs are designed to target local tissue and, as such, have limited systemic absorption. For these drugs, the pharmacokinetic measurements in the local tissue (skin) are of more importance than systemic measurements. In this context, this study aims to develop and discuss the... Read more.
DOI: 10.5897/AJPP2015.4405[Article Number: 3E988DE60965]
There is a resurgence in the use of herbal medicine in the developed countries, with even much more in low developed Countries and especially for conditions such as erectile dysfunction. Studies thus need to be conducted to scientifically validate claims on certain medicinal plants reported to be efficacious in traditional medicine. This current study was conducted to determine the phytochemical composition and efficacy... Read more.
DOI: 10.5897/AJPP2016.4603[Article Number: 41375DF60982]
In the present investigation, the methanol leaves extract of Podocarpus neriifolius D. Don was assessed for antibacterial and antioxidant activities. The antibacterial action was evaluated through agar disc diffusion method against seven pathogenic and non-pathogenic bacterial strains at various concentrations and compared against the standard (kanamycin 30 µg/disc). The antioxidant activity of the extract was... Read more.
DOI: 10.5897/AJPP2016.4647[Article Number: 841E71E60987]
Wissadula periplocifolia (L.) C. Presl. is a medicinal plant widely distributed in USA, but it has not yet been investigated extensively. Some pharmacochemical studies were performed at the Federal University of Paraiba, and the components of the crude ethanolic extract were identified; one of them was a tiliroside, which has already been shown to have excellent anti-inflammatory activity that can inhibit the... Read more.
DOI: 10.5897/AJPP2016.4671[Article Number: F37A64C60747]
Hydantoins are often reported as potent anticonvulsant drugs; however, recent studies have highlighted their antinociceptive potential. Based on these reports, this study investigated the antinociceptive and anti-inflammatory activities of the hydantoin derivative 5-(4-isopropylphenyl)-3-phenyl-imidazolidine-2,4-dione (IM-7) using animal models. Treated mice submitted to the acetic acid-induced writhing test showed... Read more.
Page 1 of 99, showing 20 records out of 1975 total, starting on record 1, ending on 20