Abbreviation: Afr. J. Pharm. Pharmacol.
Start Year: 2007
Page 1 of 103, showing 20 records out of 2054 total, starting on record 1, ending on 20
DOI: 10.5897/AJPP2017.4846[Article Number: CD323DE66946]
Gas chromatography-mass spectrometry (GC-MS) analysis and antioxidants activity of phytochemical constituents from ethyl acetate fraction of Vernonia calvoana (V.C) was evaluated. The fraction was subjected to GC–MS analysis using 5% diphenyl 95% dimethylpolysiloxane (30 m × 0.25 mm ID × 0.25 µm film thickness), the compounds were separated and identified by Turbo gold mass detector. The... Read more.
DOI: 10.5897/AJPP2017.4835[Article Number: 389C1FE66758]
Bryophyllum pinnatum is a known herb found in the tropical region of Africa and other parts of the world. In this study, the ethanol extract of the plant was investigated for possible anti-diabetic effect on alloxan induced hyperglycaemic wistar albino rats. Phytochemical studies revealed that Flavonoids and alkaloids were highly abundant compared to steroids and terpenoids which were slightly present while glycosides... Read more.
DOI: 10.5897/AJPP2017.4848[Article Number: DB6D10566641]
The teaching model based on objective, measurable, and linear knowledge no longer seems to be the most appropriate, given the new responsibilities of pharmacists, who should focus their practices on patient care. The objective of the present study was to analyze students' perception about preparedness to pharmacy practice and to patient-centered care, and identify experiential training barriers Two discussion groups... Read more.
DOI: 10.5897/AJPP2017.4841[Article Number: C59A4C366357]
Alchornea cordifolia has been shown to be hepatoprotective against hepatotoxicity induced by high dose paracetamol in a model animal. However, its hepatoprotective effects against the hepatotoxicity induced by anti-tubercular drugs have not yet been studied, whereas anti-tubercular drugs are known to be hepatotoxic at therapeutic dose. The aim of this work was to evaluate the hepatoprotective effect of a methanol... Read more.
DOI: 10.5897/AJPP2017.4842[Article Number: FF5C57C66360]
Vanadium may or may not be a cholesterol-lowering agent. It could potentially be used as an additional therapy or alone in therapies for treatment of dyslipidemia. This study aimed to investigate the effect of vanadium on hypercholesterolemia in the presence and absence of statins. Sixty rats were divided into five groups. The first group was kept on a normal diet and the second group was kept on a high fat diet. The... Read more.
DOI: 10.5897/AJPP2017.4828[Article Number: 3C7DFE066305]
The blood schizontocidal chloroquine (CQ) and the tissue schizontocidal and gametocytocidal primaquine (PQ) remain the mainstay treatment of Plasmodium vivax and Plasmodium ovale infections for more than six decades. The review focuses on the clinical pharmacokinetic studies of both drugs in Thai population that have provided useful information for clinical application in the treatment of malaria. There appears to... Read more.
DOI: 10.5897/AJPP2017.4843[Article Number: 2CAFC3166307]
This project aimed at developing a gastro-resistant coated tablet using traditional herbal medicine dry extract from the secondary roots of the plant species Harpagophytum procumbens DC. (Pedaliaceae), standardized in harpagoside 20%, popularly known as "devil's claw". The tablets were produced by direct compression and coated with the gastro-resistant dispersion. Accelerated and long-term stability... Read more.
DOI: 10.5897/AJPP2017.4803[Article Number: 862D0A166272]
The aim of this study was to enhance the classical adjuvant functionality of maize starch (Mst) by co-processing with small quantities of carbopol 974P (CaPol). A pre-processed maize starch (MpS) was coated with different concentrations of CaPol corresponding to 0.25, 0.5, 0.75 and 1.0 %w/w and spray-dried at controlled conditions to produce the CaPol-coated motifs (MpS-CaPol). The relevant physicochemical and... Read more.
DOI: 10.5897/AJPP2017.4839[Article Number: 7D2BB3466274]
Evaluation of some metabolic activities and immuno-stimulatory potential of the methanolic seed extract of Garcinia kola (Heckel) in female albino Wistar rats was carried out using standard methods. Animals in treated groups were administered 125, 250 and 500 mg/kg body weight, respectively of the extract through the oral route for 21 days. The control group received normal saline (0.5 ml/100 g body weight) for the same... Read more.
DOI: 10.5897/AJPP2017.4816[Article Number: 7E33DBE66179]
Elevated level of cholesterol is a risk factor for the development of cardiovascular disease. Community pharmacies are considered as ideal settings to provide screening services for chronic medical conditions. An adequate knowledge and a positive attitude towards cholesterol screening would increase pharmacist’s involvement in cholesterol lowering interventions and referrals. The objective of this study was to... Read more.
DOI: 10.5897/AJPP2016.4574[Article Number: 38E147365630]
Adverse drug reaction (ADR) is a noxious and undesirable reaction to drugs at dosage normally used in humans for diagnosis, treatment or prophylaxis of diseases or ailments. Spontaneous reporting is currently the major back bone for the detection of adverse drug reactions. The objective of the study was to assess the knowledge, attitude, and practice of health professionals towards ADR reporting in Boru Meda Hospital,... Read more.
DOI: 10.5897/AJPP2017.4810[Article Number: E9BC18965634]
The increased demand for herbal remedies and natural quest for alcohol consumption has positioned alcoholic herbal preparations (bitters) as ideal drink. Bitters are acclaimed to have blood detoxifying and liver cleansing potentials. This study investigated the acclaimed detoxifying potentials of an alcoholic bitter (AB) on carbon tetrachloride (CCl4) induced toxicity. Twenty five male Wistar albino rats were grouped... Read more.
DOI: 10.5897/AJPP2016.4685[Article Number: F44BB2265997]
Hypertension remains a global challenge even in the 21st century with attendant increase in mortality rate. The quest for alternative management medications suffixed this investigation using three varieties. Thirty male hypertension induced wistar rats divided into 6 groups of 5 rats each were used. Group A served as the normal control group and was administered 0.9% normal saline as placebo. Group B, C and D were fed... Read more.
DOI: 10.5897/AJPP2017.4815[Article Number: 98FCC7B65999]
Gentamicin is widely used as an effective antibiotic. A study was conducted to investigate the effects of intramuscular administration of gentamicin on 20, 5 to 6 weeks male Swiss albino mice weighing 25 to 30 g. The mice were divided into 4 groups: Group A (kept as control); groups B, C and D (treated with gentamicin intramuscularly daily at the dose rate of 5 mg/kg for 7 days, 5 mg/kg for 30 days, and 10 mg/kg for 30... Read more.
DOI: 10.5897/AJPP2017.4739[Article Number: B5B56D866001]
This work was designed to access reproductive status of Cypermethrin treated rams by measuring the scrotal circumference, live weight, live testicular width and length as well as some physiological parameters to determine its reproductive and general toxicity in Yankasa rams. Sixteen rams aged 18 to 30 months and weighing between 21.5 and 46.5 kg were used for this study. The 16 rams were divided equally into two... Read more.
DOI: 10.5897/AJPP2017.4824[Article Number: 106376F66007]
Mrityunjay is a plant based ayurvedic preparation which is used in the treatment of high blood pressure as well as other cardiovascular diseases. It comprises of significant cardioprotective constituents. This study was conducted to evaluate the effect of Mrityunjay on digoxin-induced arrhythmia and lipid profile in rats. Rats were orally pre-treated with Mrityunjay at the doses of 0.28 and 2.8 mL/kg b.w. for... Read more.
DOI: 10.5897/AJPP2017.4819[Article Number: DCD78B465828]
Endopleura uchi (Huber) Cuatrec. (Humiriaceae), the Brazilian Amazon plant, is used in folk medicine to treat arthritis and gastric ulcer. Bergenin, one of the chemical constituents of E. uchi, has anti-inflammatory properties. Its acetylation results in acetylbergenin, which is extracted to investigate its potential anti-inflammatory and antiulcer properties using an assay for croton oil-induced ear edema, rat paw... Read more.
DOI: 10.5897/AJPP2017.4811[Article Number: 842BBAB65869]
Plant derived bioactive molecules are always in demand and are the main focus of research. Despite the growing market demand for herbal medicines, safety of medicinal plants is still a concern. The present work aimed at generating preliminary phytochemical and biosafety information of crude methanolic and chloroform extracts of Cissus quadrangularis L. (aerial parts) and Solunumincanum L. (fruit). Both plants are... Read more.
DOI: 10.5897/AJPP2017.4784[Article Number: B27635665682]
In this study, phytochemical screening and evaluation were done for the antiplasmodial activity using in vitro test in Plasmodium falciparum and in vivo test in murine model (Plasmodium berghei) of the crude ethanolic extract of roots of Amasonia campestris (Aubl.) Moldenke (CEEAc), popularly known as mendoca and according to surveys ethnobotanically performed in this study, it is used as antimalarial in the State of... Read more.
DOI: 10.5897/AJPP2017.4820[Article Number: F5043C365684]
Ulcerative colitis is a serious premalignant condition with a confusing multifactorial pathogenesis. It should warrant all attention by researchers, for exploration of new prophylactic or therapeutic drugs targeting its pathophysiology. The current study was conducted to study the possible role of tadalafil and its potential actions in ulcerative colitis rat model, induced by acetic acid. Forty eight male Wistar albino... Read more.
Page 1 of 103, showing 20 records out of 2054 total, starting on record 1, ending on 20