Abbreviation: Afr. J. Pharm. Pharmacol.
Start Year: 2007
Page 1 of 103, showing 20 records out of 2047 total, starting on record 1, ending on 20
DOI: 10.5897/AJPP2017.4803[Article Number: 862D0A166272]
The aim of this study was to enhance the classical adjuvant functionality of maize starch (Mst) by co-processing with small quantities of carbopol 974P (CaPol). A pre-processed maize starch (MpS) was coated with different concentrations of CaPol corresponding to 0.25, 0.5, 0.75 and 1.0 %w/w and spray-dried at controlled conditions to produce the CaPol-coated motifs (MpS-CaPol). The relevant physicochemical and... Read more.
DOI: 10.5897/AJPP2017.4839[Article Number: 7D2BB3466274]
Evaluation of some metabolic activities and immuno-stimulatory potential of the methanolic seed extract of Garcinia kola (Heckel) in female albino Wistar rats was carried out using standard methods. Animals in treated groups were administered 125, 250 and 500 mg/kg body weight, respectively of the extract through the oral route for 21 days. The control group received normal saline (0.5 ml/100 g body weight) for the same... Read more.
DOI: 10.5897/AJPP2017.4816[Article Number: 7E33DBE66179]
Elevated level of cholesterol is a risk factor for the development of cardiovascular disease. Community pharmacies are considered as ideal settings to provide screening services for chronic medical conditions. An adequate knowledge and a positive attitude towards cholesterol screening would increase pharmacist’s involvement in cholesterol lowering interventions and referrals. The objective of this study was to... Read more.
DOI: 10.5897/AJPP2016.4574[Article Number: 38E147365630]
Adverse drug reaction (ADR) is a noxious and undesirable reaction to drugs at dosage normally used in humans for diagnosis, treatment or prophylaxis of diseases or ailments. Spontaneous reporting is currently the major back bone for the detection of adverse drug reactions. The objective of the study was to assess the knowledge, attitude, and practice of health professionals towards ADR reporting in Boru Meda Hospital,... Read more.
DOI: 10.5897/AJPP2017.4810[Article Number: E9BC18965634]
The increased demand for herbal remedies and natural quest for alcohol consumption has positioned alcoholic herbal preparations (bitters) as ideal drink. Bitters are acclaimed to have blood detoxifying and liver cleansing potentials. This study investigated the acclaimed detoxifying potentials of an alcoholic bitter (AB) on carbon tetrachloride (CCl4) induced toxicity. Twenty five male Wistar albino rats were grouped... Read more.
DOI: 10.5897/AJPP2016.4685[Article Number: F44BB2265997]
Hypertension remains a global challenge even in the 21st century with attendant increase in mortality rate. The quest for alternative management medications suffixed this investigation using three varieties. Thirty male hypertension induced wistar rats divided into 6 groups of 5 rats each were used. Group A served as the normal control group and was administered 0.9% normal saline as placebo. Group B, C and D were fed... Read more.
DOI: 10.5897/AJPP2017.4815[Article Number: 98FCC7B65999]
Gentamicin is widely used as an effective antibiotic. A study was conducted to investigate the effects of intramuscular administration of gentamicin on 20, 5 to 6 weeks male Swiss albino mice weighing 25 to 30 g. The mice were divided into 4 groups: Group A (kept as control); groups B, C and D (treated with gentamicin intramuscularly daily at the dose rate of 5 mg/kg for 7 days, 5 mg/kg for 30 days, and 10 mg/kg for 30... Read more.
DOI: 10.5897/AJPP2017.4739[Article Number: B5B56D866001]
This work was designed to access reproductive status of Cypermethrin treated rams by measuring the scrotal circumference, live weight, live testicular width and length as well as some physiological parameters to determine its reproductive and general toxicity in Yankasa rams. Sixteen rams aged 18 to 30 months and weighing between 21.5 and 46.5 kg were used for this study. The 16 rams were divided equally into two... Read more.
DOI: 10.5897/AJPP2017.4824[Article Number: 106376F66007]
Mrityunjay is a plant based ayurvedic preparation which is used in the treatment of high blood pressure as well as other cardiovascular diseases. It comprises of significant cardioprotective constituents. This study was conducted to evaluate the effect of Mrityunjay on digoxin-induced arrhythmia and lipid profile in rats. Rats were orally pre-treated with Mrityunjay at the doses of 0.28 and 2.8 mL/kg b.w. for... Read more.
DOI: 10.5897/AJPP2017.4819[Article Number: DCD78B465828]
Endopleura uchi (Huber) Cuatrec. (Humiriaceae), the Brazilian Amazon plant, is used in folk medicine to treat arthritis and gastric ulcer. Bergenin, one of the chemical constituents of E. uchi, has anti-inflammatory properties. Its acetylation results in acetylbergenin, which is extracted to investigate its potential anti-inflammatory and antiulcer properties using an assay for croton oil-induced ear edema, rat paw... Read more.
DOI: 10.5897/AJPP2017.4811[Article Number: 842BBAB65869]
Plant derived bioactive molecules are always in demand and are the main focus of research. Despite the growing market demand for herbal medicines, safety of medicinal plants is still a concern. The present work aimed at generating preliminary phytochemical and biosafety information of crude methanolic and chloroform extracts of Cissus quadrangularis L. (aerial parts) and Solunumincanum L. (fruit). Both plants are... Read more.
DOI: 10.5897/AJPP2017.4784[Article Number: B27635665682]
In this study, phytochemical screening and evaluation were done for the antiplasmodial activity using in vitro test in Plasmodium falciparum and in vivo test in murine model (Plasmodium berghei) of the crude ethanolic extract of roots of Amasonia campestris (Aubl.) Moldenke (CEEAc), popularly known as mendoca and according to surveys ethnobotanically performed in this study, it is used as antimalarial in the State of... Read more.
DOI: 10.5897/AJPP2017.4820[Article Number: F5043C365684]
Ulcerative colitis is a serious premalignant condition with a confusing multifactorial pathogenesis. It should warrant all attention by researchers, for exploration of new prophylactic or therapeutic drugs targeting its pathophysiology. The current study was conducted to study the possible role of tadalafil and its potential actions in ulcerative colitis rat model, induced by acetic acid. Forty eight male Wistar albino... Read more.
DOI: 10.5897/AJPP2017.4804[Article Number: FF8770E65686]
This study presents results of ozonation of some different aromatic rings of medicines in aqueous solution. The aim of the research was to investigate the influence of ozone on ring cleavage of drug molecules with an aromatic structure. In this regard, phenobarbital, naphazoline, doxycycline, isoniazid and salbutamol were chosen for exposure to ozone gas overnight. It is proved that ozone can attack the OH groups,... Read more.
DOI: 10.5897/AJPP2017.4779[Article Number: 69686D965475]
The chemotherapeutic efficacy of secnidazole-diminazene aceturate (SEC-DA) combination therapy was studied in rats experimentally infected with Trypanosoma brucei brucei with a view of eliminating relapse of infection. Twenty rats grouped into 4 groups (n = 5) were used for the study as follows: uninfected untreated (A), infected untreated (B), infected and treated with diminazene (DA) (3.5 mg/kg) alone intraperitoneum... Read more.
DOI: 10.5897/AJPP2017.4812[Article Number: 41FCE3365477]
Many pathological conditions are associated with pain, fever and inflammation. Synthetic drugs available for the treatment of these ailments accompany many unwanted side effect; most prominent of which is the gastric ulcer. Present study was thus aimed at evaluating the analgesic, anti-pyretic and anti-inflammatory potential of aqueous methanolic extract of leaves of plant Jatropha gossypifolia. Anti-inflammatory... Read more.
DOI: 10.5897/AJPP2017.4796[Article Number: FE7931065420]
Insulin, a hormonal drug for the management of diabetes mellitus has continued to attract attention of many researchers and pharmaceutical formulators for more than a decade. However, its low oral bioavailability due to the activities of intestinal enzymes restricts its route of administration to only the parenteral route. This study was designed to evaluate the capacity of mucoadhesive microspheres formulated with... Read more.
DOI: 10.5897/AJPP2017.4571[Article Number: F6FDF4765425]
Previous studies have reported poor awareness of the Pharmacovigilance Programme (PP) among health professionals in Nigeria but similar information on the general population is unavailable. This study was designed to investigate the individual and contextual factors associated with awareness of the PP among the general population. The study utilised data collected in the 2012 National HIV and AIDS and Reproductive... Read more.
DOI: 10.5897/AJPP2017.4789[Article Number: 235215D65351]
Intensive use of antimicrobial agents in aquaculture provides a selective pressure creating reservoirs of drug-resistant bacteria and transferable resistance genes in fish pathogens and other bacteria in the aquatic environment. From these reservoirs, resistance genes may disseminate by horizontal gene transfer and reach human pathogens, or drug-resistant pathogens from the aquatic environment may reach humans directly.... Read more.
DOI: 10.5897/AJPP2017.4798[Article Number: BB336CF65360]
Croton heliotropiifolius Kunth is an endemic specie in northeast of Brazil. It is renowned for its medicinal properties, larvicidal and insecticidal actions. This work investigated the chemical compounds present in the methanolic extract of Croton heliotropiifolius and the cytotoxic activity. Physical-chemical analyses were performed by thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC),... Read more.
Page 1 of 103, showing 20 records out of 2047 total, starting on record 1, ending on 20