Abbreviation: Afr. J. Pharm. Pharmacol.
Start Year: 2007
Page 1 of 103, showing 20 records out of 2044 total, starting on record 1, ending on 20
DOI: 10.5897/AJPP2016.4574[Article Number: 38E147365630]
Adverse drug reaction (ADR) is a noxious and undesirable reaction to drugs at dosage normally used in humans for diagnosis, treatment or prophylaxis of diseases or ailments. Spontaneous reporting is currently the major back bone for the detection of adverse drug reactions. The objective of the study was to assess the knowledge, attitude, and practice of health professionals towards ADR reporting in Boru Meda Hospital,... Read more.
DOI: 10.5897/AJPP2017.4810[Article Number: E9BC18965634]
The increased demand for herbal remedies and natural quest for alcohol consumption has positioned alcoholic herbal preparations (bitters) as ideal drink. Bitters are acclaimed to have blood detoxifying and liver cleansing potentials. This study investigated the acclaimed detoxifying potentials of an alcoholic bitter (AB) on carbon tetrachloride (CCl4) induced toxicity. Twenty five male Wistar albino rats were grouped... Read more.
DOI: 10.5897/AJPP2016.4685[Article Number: F44BB2265997]
Hypertension remains a global challenge even in the 21st century with attendant increase mortality rate. The quest for alternative management medications suffixed this investigation using three varieties. Thirty male hypertension induced wistar rats divided into 6 groups of 5 rats each were used. Group A served as the normal control group and was administered 0.9% normal saline as placebo. Group B, C and D were fed with... Read more.
DOI: 10.5897/AJPP2017.4815[Article Number: 98FCC7B65999]
Gentamicin is widely used as an effective antibiotic. A study was conducted to investigate the effects of intramuscular administration of gentamicin on 20, 5 to 6 weeks male Swiss albino mice weighing 25 to 30 g. The mice were divided into 4 groups: Group A (kept as control); groups B, C and D (treated with gentamicin intramuscularly daily at the dose rate of 5 mg/kg for 7 days, 5 mg/kg for 30 days, and 10 mg/kg for 30... Read more.
DOI: 10.5897/AJPP2017.4739[Article Number: B5B56D866001]
This work was designed to access reproductive status of Cypermethrin treated rams by measuring the scrotal circumference, live weight, live testicular width and length as well as some physiological parameters to determine its reproductive and general toxicity in Yankasa rams. Sixteen rams aged 18 to 30 months and weighing between 21.5 and 46.5 kg were used for this study. The 16 rams were divided equally into two... Read more.
DOI: 10.5897/AJPP2017.4824[Article Number: 106376F66007]
Mrityunjay is a plant based ayurvedic preparation which is used in the treatment of high blood pressure as well as other cardiovascular diseases. It comprises of significant cardioprotective constituents. This study was conducted to evaluate the effect of Mrityunjay on digoxin-induced arrhythmia and lipid profile in rats. Rats were orally pre-treated with Mrityunjay at the doses of 0.28 and 2.8 mL/kg b.w. for... Read more.
DOI: 10.5897/AJPP2017.4819[Article Number: DCD78B465828]
Endopleura uchi (Huber) Cuatrec. (Humiriaceae), the Brazilian Amazon plant, is used in folk medicine to treat arthritis and gastric ulcer. Bergenin, one of the chemical constituents of E. uchi, has anti-inflammatory properties. Its acetylation results in acetylbergenin, which is extracted to investigate its potential anti-inflammatory and antiulcer properties using an assay for croton oil-induced ear edema, rat paw... Read more.
DOI: 10.5897/AJPP2017.4811[Article Number: 842BBAB65869]
Plant derived bioactive molecules are always in demand and are the main focus of research. Despite the growing market demand for herbal medicines, safety of medicinal plants is still a concern. The present work aimed at generating preliminary phytochemical and biosafety information of crude methanolic and chloroform extracts of Cissus quadrangularis L. (aerial parts) and Solunumincanum L. (fruit). Both plants are... Read more.
DOI: 10.5897/AJPP2017.4784[Article Number: B27635665682]
In this study, phytochemical screening and evaluation were done for the antiplasmodial activity using in vitro test in Plasmodium falciparum and in vivo test in murine model (Plasmodium berghei) of the crude ethanolic extract of roots of Amasonia campestris (Aubl.) Moldenke (CEEAc), popularly known as mendoca and according to surveys ethnobotanically performed in this study, it is used as antimalarial in the State of... Read more.
DOI: 10.5897/AJPP2017.4820[Article Number: F5043C365684]
Ulcerative colitis is a serious premalignant condition with a confusing multifactorial pathogenesis. It should warrant all attention by researchers, for exploration of new prophylactic or therapeutic drugs targeting its pathophysiology. The current study was conducted to study the possible role of tadalafil and its potential actions in ulcerative colitis rat model, induced by acetic acid. Forty eight male Wistar albino... Read more.
DOI: 10.5897/AJPP2017.4804[Article Number: FF8770E65686]
This study presents results of ozonation of some different aromatic rings of medicines in aqueous solution. The aim of the research was to investigate the influence of ozone on ring cleavage of drug molecules with an aromatic structure. In this regard, phenobarbital, naphazoline, doxycycline, isoniazid and salbutamol were chosen for exposure to ozone gas overnight. It is proved that ozone can attack the OH groups,... Read more.
DOI: 10.5897/AJPP2017.4779[Article Number: 69686D965475]
The chemotherapeutic efficacy of secnidazole-diminazene aceturate (SEC-DA) combination therapy was studied in rats experimentally infected with Trypanosoma brucei brucei with a view of eliminating relapse of infection. Twenty rats grouped into 4 groups (n = 5) were used for the study as follows: uninfected untreated (A), infected untreated (B), infected and treated with diminazene (DA) (3.5 mg/kg) alone intraperitoneum... Read more.
DOI: 10.5897/AJPP2017.4812[Article Number: 41FCE3365477]
Many pathological conditions are associated with pain, fever and inflammation. Synthetic drugs available for the treatment of these ailments accompany many unwanted side effect; most prominent of which is the gastric ulcer. Present study was thus aimed at evaluating the analgesic, anti-pyretic and anti-inflammatory potential of aqueous methanolic extract of leaves of plant Jatropha gossypifolia. Anti-inflammatory... Read more.
DOI: 10.5897/AJPP2017.4796[Article Number: FE7931065420]
Insulin, a hormonal drug for the management of diabetes mellitus has continued to attract attention of many researchers and pharmaceutical formulators for more than a decade. However, its low oral bioavailability due to the activities of intestinal enzymes restricts its route of administration to only the parenteral route. This study was designed to evaluate the capacity of mucoadhesive microspheres formulated with... Read more.
DOI: 10.5897/AJPP2017.4571[Article Number: F6FDF4765425]
Previous studies have reported poor awareness of the Pharmacovigilance Programme (PP) among health professionals in Nigeria but similar information on the general population is unavailable. This study was designed to investigate the individual and contextual factors associated with awareness of the PP among the general population. The study utilised data collected in the 2012 National HIV and AIDS and Reproductive... Read more.
DOI: 10.5897/AJPP2017.4789[Article Number: 235215D65351]
Intensive use of antimicrobial agents in aquaculture provides a selective pressure creating reservoirs of drug-resistant bacteria and transferable resistance genes in fish pathogens and other bacteria in the aquatic environment. From these reservoirs, resistance genes may disseminate by horizontal gene transfer and reach human pathogens, or drug-resistant pathogens from the aquatic environment may reach humans directly.... Read more.
DOI: 10.5897/AJPP2017.4798[Article Number: BB336CF65360]
Croton heliotropiifolius Kunth is an endemic specie in northeast of Brazil. It is renowned for its medicinal properties, larvicidal and insecticidal actions. This work investigated the chemical compounds present in the methanolic extract of Croton heliotropiifolius and the cytotoxic activity. Physical-chemical analyses were performed by thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC),... Read more.
DOI: 10.5897/AJPP2017.4799[Article Number: 9A9716865288]
The aim is to evaluate the medication incidents relating to incorrect oral medication preparation and administration through enteral feeding tubes in hospitalized patients. A cross-sectional design was used to observe 374 doses of medications at three Brazilian hospitals. The patients consisted mostly of females (48.6%), elderly (65.71%), using polyurethane tubes (82.9%), with jejunal access (82.9%), and circulatory... Read more.
DOI: 10.5897/AJPP2016.4582[Article Number: 856C94C65290]
Studies on the cacti of the genera, Hylocereus Tropical and Subtropical America are scarce. Cultivation and consumption of different species and varieties of pitaya (Hylocereus undatus) may represent a source of diversified agricultural activity since these species contain rich bioactive compounds that add a rustic beauty to the cultivation of the fruit in addition to the benefits they bring to the health of the... Read more.
DOI: 10.5897/AJPP2017.4780[Article Number: 9CDD45865153]
High levels of cyclooxygenase (COX) enzymes and its metabolites, especially prostaglandin E2 (PGE2) are generated in inflammatory conditions and, eventually, can contribute to neoplasms growth, justifying, in certain malignancies. COX occurs in two major isoforms, physiologically as isoform COX-1 and during inflammation as COX-2. In certain neoplasms, benefits are reported with the use of the selective COX-2 inhibitor... Read more.
Page 1 of 103, showing 20 records out of 2044 total, starting on record 1, ending on 20