Abbreviation: Afr. J. Pharm. Pharmacol.
Start Year: 2007
Page 1 of 102, showing 20 records out of 2033 total, starting on record 1, ending on 20
DOI: 10.5897/AJPP2017.4779[Article Number: 69686D965475]
The chemotherapeutic efficacy of secnidazole-diminazene aceturate (SEC-DA) combination therapy was studied in rats experimentally infected with Trypanosoma brucei brucei with a view of eliminating relapse of infection. Twenty rats grouped into 4 groups (n = 5) were used for the study as follows: uninfected untreated (A), infected untreated (B), infected and treated with diminazene (DA) (3.5 mg/kg) alone intraperitoneum... Read more.
DOI: 10.5897/AJPP2017.4812[Article Number: 41FCE3365477]
Many pathological conditions are associated with pain, fever and inflammation. Synthetic drugs available for the treatment of these ailments accompany many unwanted side effect; most prominent of which is the gastric ulcer. Present study was thus aimed at evaluating the analgesic, anti-pyretic and anti-inflammatory potential of aqueous methanolic extract of leaves of plant Jatropha gossypifolia. Anti-inflammatory... Read more.
DOI: 10.5897/AJPP2017.4796[Article Number: FE7931065420]
Insulin, a hormonal drug for the management of diabetes mellitus has continued to attract attention of many researchers and pharmaceutical formulators for more than a decade. However, its low oral bioavailability due to the activities of intestinal enzymes restricts its route of administration to only the parenteral route. This study was designed to evaluate the capacity of mucoadhesive microspheres formulated with... Read more.
DOI: 10.5897/AJPP2017.4571[Article Number: F6FDF4765425]
Previous studies have reported poor awareness of the Pharmacovigilance Programme (PP) among health professionals in Nigeria but similar information on the general population is unavailable. This study was designed to investigate the individual and contextual factors associated with awareness of the PP among the general population. The study utilised data collected in the 2012 National HIV and AIDS and Reproductive... Read more.
DOI: 10.5897/AJPP2017.4789[Article Number: 235215D65351]
Intensive use of antimicrobial agents in aquaculture provides a selective pressure creating reservoirs of drug-resistant bacteria and transferable resistance genes in fish pathogens and other bacteria in the aquatic environment. From these reservoirs, resistance genes may disseminate by horizontal gene transfer and reach human pathogens, or drug-resistant pathogens from the aquatic environment may reach humans directly.... Read more.
DOI: 10.5897/AJPP2017.4798[Article Number: BB336CF65360]
Croton heliotropiifolius Kunth is an endemic specie in northeast of Brazil. It is renowned for its medicinal properties, larvicidal and insecticidal actions. This work investigated the chemical compounds present in the methanolic extract of Croton heliotropiifolius and the cytotoxic activity. Physical-chemical analyses were performed by thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC),... Read more.
DOI: 10.5897/AJPP2017.4799[Article Number: 9A9716865288]
The aim is to evaluate the medication incidents relating to incorrect oral medication preparation and administration through enteral feeding tubes in hospitalized patients. A cross-sectional design was used to observe 374 doses of medications at three Brazilian hospitals. The patients consisted mostly of females (48.6%), elderly (65.71%), using polyurethane tubes (82.9%), with jejunal access (82.9%), and circulatory... Read more.
DOI: 10.5897/AJPP2016.4582[Article Number: 856C94C65290]
Studies on the cacti of the genera, Hylocereus Tropical and Subtropical America are scarce. Cultivation and consumption of different species and varieties of pitaya (Hylocereus undatus) may represent a source of diversified agricultural activity since these species contain rich bioactive compounds that add a rustic beauty to the cultivation of the fruit in addition to the benefits they bring to the health of the... Read more.
DOI: 10.5897/AJPP2017.4780[Article Number: 9CDD45865153]
High levels of cyclooxygenase (COX) enzymes and its metabolites, especially prostaglandin E2 (PGE2) are generated in inflammatory conditions and, eventually, can contribute to neoplasms growth, justifying, in certain malignancies. COX occurs in two major isoforms, physiologically as isoform COX-1 and during inflammation as COX-2. In certain neoplasms, benefits are reported with the use of the selective COX-2 inhibitor... Read more.
DOI: 10.5897/AJPP2017.4802[Article Number: 9222E5C65107]
Methylphenidate, marketed as Ritalin, is an emerged pollutant found in wastewater. Methylphenidate exposure at pharmacological doses can modify brain metabolism, however, the consequences of environmental residues remains to be elucidated. This work presents the results of a chronic exposure to methylphenidate residual levels (0.1875 and 1.875 µg/L) consistent with the amount found in the environment. Animals were... Read more.
DOI: 10.5897/AJPP2017.4774[Article Number: 1BDFE5E65016]
Iron deficiency anemia poses a burden on the limited health care delivery system in India. Current pharmacological anti anemic agents cause undesirable side effect such as nausea, vomiting and dark stool. Herbal extract as a nutritional support therapy offer the potential for alternative treatment strategies. In this context, the goal of this study was to provide plant extract formulation for anemia treatment in... Read more.
DOI: 10.5897/AJPP2017.4795[Article Number: 6808F3664876]
Entamoeba histolytica and Giardia lamblia are parasitic protozoa that cause gastrointestinal disorders such as diarrhea and dysentery. Naegleria fowleri is a free living amoeba that causes primary amoebic meningoencephalitis. However, there are limited treatments for these parasitic diseases. Extracts, fractions from extracts and some isolated compounds from selected Ghanaian medicinal plants were screened against... Read more.
DOI: 10.5897/AJPP2017.4788[Article Number: 93D969164727]
Since antimicrobials are used to fight infectious diseases, their proper use is a major world concern. The use of more than one medicine in the treatment of infectious disease is controversial hence the association therapy is used empirically to treat severe infections when one antimicrobial alone is not sufficient to account for all possible pathogens involved in the infection. The importance of understanding the... Read more.
DOI: 10.5897/AJPP2017.4754[Article Number: B3DAE9C64636]
To evaluate the new emerging role of community pharmacist and the challenges they are facing among the profession and public. A qualitative study approach was adopted in three different cities of Pakistan for a period of four months; a questionnaire based interview guide was developed after extensively reviewing the literature and utilized to collect the data. The respondents were community pharmacists and all the... Read more.
DOI: 10.5897/AJPP2017.4730[Article Number: F0BB9D564545]
Hibiscus sabdariffa is among the medicinal plants which have been shown to possess several medicinal properties. The present study was conducted to investigate the antioxidant and haematological properties of the aqueous leaf extract of H. sabdariffa on acetaminophen-challenged liver using rat model. Twenty (20) Wistar albino rats were used for this study and were divided into 4 groups of 5 rats each. Group 1 rats were... Read more.
DOI: 10.5897/AJPP2017.4791[Article Number: 71692F564567]
Chad is a country where self-medication and use of antibiotic without medical prescriptions are still observed. These practices lead to the apparent emergence of resistance to antibiotics for bacteria. The aim of this study was to assess the abusive and inappropriate use of antibiotics among the communities. The surveys were conducted in N'Djamena and Moundou, two major cities of Chad. All the respondents were aged... Read more.
DOI: 10.5897/AJPP2017.4770[Article Number: 935D61464395]
A series of several diazenyl schiff base molecules were designed and synthesized through azo coupling of diazotised primary amines with the novel synthesized schiff base ligand (E)-N-((2-chloroquinolin-3-yl)methylene)-4-phenylthiazol-2-amine. All the synthesized molecules have been characterized by different spectral techniques for their structural confirmation. The results of in vitro antioxidant activity of the... Read more.
DOI: 10.5897/AJPP2015.4438[Article Number: AF8B2F164397]
This paper describes the anticholinesterase and antioxidant activities of Eugenia dysenterica DC. (O. Berg. (Myrtaceae) essential oils from leaves (EOED). EOED were obtained by hydrodistillation using a Clevenger-type apparatus and the products were analyzed by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detector (GC-FID). The main constituents of EOED were caryophyllene oxide... Read more.
DOI: 10.5897/AJPP2017.4778[Article Number: 747707A64307]
Atemoya, from family Annonaceae, is an interspecific hybrid between Annona cherimola Mill and Annona squamosa L. It is a tree from a region in diversity of plants, the Caatinga, one of the main Brazilian biomes. In this research, the effects of ethanolic extract of atemoya (Acs-EtOH) were investigated in relief of pain and inflammation in experimental models in rodents. The evaluation of antinociceptive activity was... Read more.
DOI: 10.5897/AJPP2017.4747[Article Number: 68FE7FE64077]
The purpose of this study was to understand and investigate the phytochemical and antimicrobial effects of different fractions of the methanolic extract of Corchorus capsularis leaf. For the extraction of lipophilic compounds with the help of methanol solvent system, cold extraction process was used, where the grinded coarse powder of the leaf was soaked in methanol and kept for four days for proper extraction. After... Read more.
Page 1 of 102, showing 20 records out of 2033 total, starting on record 1, ending on 20