Abbreviation: Afr. J. Pharm. Pharmacol.
Start Year: 2007
Page 1 of 101, showing 20 records out of 2002 total, starting on record 1, ending on 20
DOI: 10.5897/AJPP2017.4744[Article Number: A3956EF63234]
The non-vitamin K antagonist oral anticoagulants have been approved since 2008 for the prevention of systemic embolism and stroke in patients with non-valvular atrial fibrillation with prior stroke, transient ischemic attack, or CHA2DS2-VASc score ≥2. According to the latest guidelines of 2016, if CHA2DS2-VASc score ≥2 for all male patients or if CHA2DS2-VASc score ≥3 for all female patients, oral... Read more.
DOI: 10.5897/AJPP2017.4735[Article Number: 866051E63218]
Annona senegalensis leaves are used in African Traditional Medicine as analgesic and anti-inflammatory drugs. This study aimed to investigate the analgesic and anti-inflammatory activities of total ethereal leaf extract (TEE) of A. senegalensis and its methanolic fraction (MF). Experiments were performed in acetic acid induced contortions in mice and carrageenan rat paw edema. The preventive effect of TEE (100 mg/kg,... Read more.
DOI: 10.5897/AJPP2016.4721[Article Number: 2FD663163210]
Essential oils from six different parts of Blighia unijugata Bak., were obtained using Clevenger-type apparatus; they gave yields between 0.061 and 0.824%. Chemical constituents of the oils were determined using gas chromatography coupled with mass spectrometry (GC-MS). The GC-MS analysis show forty-seven compounds are present in the leaf oil, twenty-one compounds are in stem-bark, twenty-four in stem oil, sixteen in... Read more.
DOI: 10.5897/AJPP2016.4718[Article Number: 810F48263022]
Cynara scolymus L. leaves, popularly known as globe artichoke, have cholagogue and choleretic properties which are attributed to caffeoylquinic acid derivatives. Although, there are already pharmacopoeial methods for quality control of artichoke dry leaf extract, it only shows the assessment of chlorogenic acid determination. This study aimed to adapt and validate a method for simultaneous determination of... Read more.
DOI: 10.5897/AJPP2016.4615[Article Number: 6DE57E063024]
Given the alarming incidence of antibiotic resistance in bacteria of medical importance and multiple side effects associated with the modern day chemotherapeutics, there is a constant need for new and effective therapeutic agents that could be easily extracted from our daily used Nepalese culinary. To study the antibacterial and antioxidant activity of common spices, locally available Clove (Eugenia caryophyllus),... Read more.
DOI: 10.5897/AJPP2016.4695[Article Number: 49D86AB62725]
Marine environment with rich biodiversity offer unlimited choice for novel biopolymers. Sulfated polysaccharides isolated from marine algae and bacteria constitute an important group in the marine-derived biomolecules and biopolymers. They possess unique structural features which can be exploited to their fullest potential in the development of new therapeutic molecules, design of nanocarriers and stimuli-responsive... Read more.
DOI: 10.5897/AJPP2016.4716[Article Number: 592564762727]
Plants with diverse therapeutic properties are indigenous to Namibia. Concoctions of Colophospermum mopane and Acrotome inflata are widely used traditionally in the management of respiratory, gastrointestinal and wound infections. Limited studies have validated these traditional uses particularly against resistant bacteria strains such as Pseudomonas spp. This study aimed to determine the antimicrobial activity and... Read more.
DOI: 10.5897/AJPP2016.4703[Article Number: 397183A62729]
Research and development of new antiplasmodial molecules in plant is a very important way for the development of new anti-malarial drugs. In this study, Vernonia cinerea Less (Asteraceae) was selected for its promising antiplasmodial activity because it is traditionally used in Burkina Faso to treat malaria. The aim of this study was to investigate the antiplasmodial activity of this whole plant. Five crude extracts of... Read more.
DOI: 10.5897/AJPP2016.4687[Article Number: ADBBF4D62663]
The prevalence of cardiovascular changes markedly increases with deterioration of patient's renal function and can stack up 65 to 70% in end-stage renal disease. A rapid fall in renal function is often associated with uncontrolled congestive heart failure. Beyond their lipid-lowering effect, statins have been shown to protect the heart in different diseases. Liraglutide is a glucagon-like peptide-1 (GLP-1) analogue,... Read more.
DOI: 10.5897/AJPP2016.4701[Article Number: 815E93B62665]
The use of herbal medicines or drugs without professional prescription is a recurrent practice in several regions of Brazil. This action generates risks to the user, such as intoxication, masking of disease symptoms and important pharmacological interactions. The objective of this study was to analyze the profile of phytotherapeutic and drug use, without professional prescription, among residents of the municipality of... Read more.
DOI: 10.5897/AJPP2016.4697[Article Number: 942DF1B62493]
The crude methanol extract of leaves of Jasminum matthewii as well as its hexane, carbon tetrachloride, chloroform and aqueous soluble partitionates were subjected to screening for antioxidant, cytotoxic, thrombolytic, membrane stabilizing, antimicrobial, analgesic, anti-diarrheal and central nervous system depressant activity assays. The antioxidant potential was evaluated in terms of total phenolic content and free... Read more.
DOI: 10.5897/AJPP2016.4706[Article Number: 709CD0262496]
The determination of α-glucosidase inhibitory activity and isolation of active compounds from Borassus flabellifer Linn. are the main objectives of this study. The colorimetric method and chromatographic technique were done for bioassay and phytochemistry. The results showed that, at concentration of 2 mg/ml, ethyl acetate extract inhibited α-glucosidase equally as positive standard, acarbose as 80% while... Read more.
DOI: 10.5897/AJPP2014.4699[Article Number: 39DE60862384]
The leaves of Ajuga remota benth have been utilized traditionally for the treatment of patients with diabetes mellitus. However, its use has not been scientifically validated. The present study was therefore, aimed to assess the antihyperglycemic and antihyperlipidemic activities of ethanol extract of A. remota leaves in streptozotocin (STZ) induced diabetic rats. Antihyperglycemic and antihyperlipidemic activities of... Read more.
DOI: 10.5897/AJPP2016.4712[Article Number: E3327BE62386]
Rauwolfia vomitoria Aftzel belong to the family of Apocynacea with a common name serpent wood and Igbo name as akanta. It is used traditionally to treat hypertension and rheumatoid arthritis. The present study deals with GC-MS determination and FT-IR analysis of methanolic root extract of the named plant. Exactly thirty phytochemical constituents have been identified by comparing the chromatogram peek values of unknown... Read more.
DOI: 10.5897/AJPP2016.4401[Article Number: B2C5D0C62388]
Pyrazole derivatives (I-VII) were prepared in good yields using aldol condensation followed by cyclization and were characterized by elemental analysis, IR and 1H NMR spectroscopy. In vitro antileishmanial activity test was conducted using Alamar blue reduction method. The test revealed that the synthesized compounds (except compound IIb) exhibit better antileishmanial activity than the standard drug miltefosine and... Read more.
DOI: 10.5897/AJPP2014.4186[Article Number: 2DCCAEC62209]
This study was carried out to determine acute oral toxicity and histopathological effects associated with consumption of Euphorbia heterophylla ethanolic extract using 9 to 10 weeks old Albino mice randomized in six groups. The five groups were orally administered with single graded doses of plant extract at 1500, 2000, 2500, 3500 and 4000 mg/kg body weight while the sixth group was administered 1 ml of physiological... Read more.
DOI: 10.5897/AJPP2016.4678[Article Number: E9EFE7C62211]
In traditional medicine, the leaves of Dacryodes edulis are utilised in the treatment of gastric ulcer and hence, the chloroform and ethanol layers of the chloroform-ethanol extract of the leaves of D. edulis were evaluated for their anti-oxidant vitamin contents and proximate compositions. Based on preliminary investigations, the more promising layer (ethanol layer) was further fractionated and the effects of the... Read more.
DOI: 10.5897/AJPP2015.4312[Article Number: 2A23B6462203]
An important chlorophyll-derived diterpenoid essential oil, phytol (PYT) bio-metabolite, phytanic acid (PA) has a number of pathophysiological contributions. The PA metabolism and its plasma levels associated phenomena are continuously being researched on. This study aims to look at the complete current scenario of PA. The findings suggest that PA has anti-diabetic, cytotoxic, anticancer and anti-teratogenic activities.... Read more.
DOI: 10.5897/AJPP2016.4689[Article Number: CF86F0662160]
We report herein some phytopharmaceutical properties of commonly marketed teas in Nigeria. The organoleptic and physicochemical properties such as color, odor, physical appearance as well as ash value, moisture content, flow properties, pH and solubility were interrogated using standard methods as the measure of their phytopharmaceutical properties. The results show that, all the teas were coarse in nature and the... Read more.
DOI: 10.5897/AJPP2016.4684[Article Number: 4CC37A362172]
Antioxidant capacity, phenolic content, antimicrobial and cytotoxic properties of extracts and fractions from flowers and fruits of G. uruguensis were evaluated. Total phenolic content ranged between 406.8 ± 20.47 and 57.98 ± 1.734 gallic acid equivalent in mg g-1 (mg GAE g-1) samples. Ethyl acetate and butanol fractions from flowers had the greatest rates in phenolic content and antioxidant activity in... Read more.
Page 1 of 101, showing 20 records out of 2002 total, starting on record 1, ending on 20