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Full Length
Research Paper
The protective effects of
Cordyceps sinensis extract on extracellular matrix
accumulation of glomerular sclerosis in rats
Li-Qun Song*, Yu Si-Ming, Ma Xiao-Peng and Jin Li-Xia
Heilongjiang University of Traditional Chinese Medicine,
Harbin 150040, China.
*Corresponding author. E-mail:
wanglikq@163.com. Tel.
0451-82162347,
0451-82162564, 0451-89585999. Fax: 86-451-821.
Accepted
18 May, 2010 |
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The objective of the
present study is to observe protective effects of
Cordyceps sinensis extract on extracellular matrix (ECM)
accumulation and explore its therapeutic mechanism. The
glomerular sclerosis model was established by unilateral
nephrectomy and injecting adriamycin. Then urinary protein,
BUN and Scr levels were measured. Renal pathological changes
were observed by light microscopy. Immunohistochemistry
technique was used to examine expressions of CTGF, FN,
Col-IV, PAI-1, and MMP-2. Compared with model group, the
urinary protein level in C. sinensis extract group
was markedly decreased. BUN and Scr levels in C. sinensis
extract group were much lower than model group, and also
lower than Fosinopril sodium group. C. sinensis
extract produced obviously therapeutic effects on glomerular
sclerosis. Immunohistochemical results presented that
expressions of CTGF, FN and Col-IV in C. sinensis
extract and Fosinopril groups were less than model group.
The expression of PAI-1 in C. sinensis extract group
was also less than model group, but MMP-2 was more expressed
than model group. Taken together, C. sinensis extract
could ameliorate glomerular sclerosis by reducing
proteinuria, decreasing the expressions of FN, Col-IV, CTGF
and PAI-1, and increasing the expression of MMP-2, Thus,
C. sinensis extract might be one novel therapeutic drug
for chronic kidney diseases.
Key
words:
Cordyceps sinensis extract, extracellular matrix,
glomerular sclerosis. |
