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Full Length
Research Paper
A novel
pentacyclic triterpene glycoside from a resin of
Commiphora glandulosa from Botswana
Daniel Motlhanka1*, Peter
Houghton2, Ana Miljkovic-Brake2 and
Solomon Habtemariam3
1Medicinal
Plant Research Laboratories, Basic Sciences Department
Botswana College of Agriculture, Bag 0027 Gaborone,
Botswana.
2Pharmacognosy
Research Laboratories, Pharmaceutical Sciences Research
Division, King’s College, University of London, 150 Stamford
Street, SE1 9NH, London, UK.
3Pharmacognosy
and Phytotherapy Research Laboratories, School of Chemical
and Life Sciences, University of Greenwich at Meadway,
Central Avenue, Chatham Maritime, Kent, ME4 4TB, Kent, UK.
*Corresponding author. E-mail:
dmotlhan@bca.bw.
Tel:
002673650221, 0026771546727, 0026774357345. Fax:
002673928753.
Accepted 13 August, 2010 |
A novel ursane-type pentacyclic triterpene glycoside,
1b,2b,3b-trihydoxy-urs-12-ene-23-oic-rhamnoside
was isolated from the resin of Commiphora
glandulosa Schinz by bioassay guided
fractionation. Crude aqueous and chloroform
extracts of the resin as well as the isolated
compound exhibited good in vitro
antibacterial activity against gram positive
bacteria (Bacillus subtilis: NCTC 10073),
(Clostridium perfringens: NCTC 8237), (Staphylococcus
aureus: NCIMB 9518) and also drug resistant
strains (S.aureus:XU212-tetracycline
resistant strain), (S. aureus
SA1199B-norfloxacin resistant strain). There was
no observed antimicrobial activity against gram
negative bacteria (Escherichia coli: NCTC
9002), (Pseudomonas aeruginosa: NCIMB
10421), (Klebsiella aerogenes: NCTC
5055); and fungal strains (Candida albicans:
NCPF 3179, Aspergillus fumigatus: NCPF
7097), Trichophyton tonsurans: NCPF 995).
The structure of the isolated compound was
elucidated on the basis of spectral data using13C-NMR,
1H-NMR and mass spectroscopy.
Key words:
Commiphora glandulosa resins,
antibacterial activity, novel pentacyclic
triterpene, Botswana medicinal plants,
antibacterial activity.
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