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African Journal of Pharmacy and Pharmacology

     
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 Afr. J. Pharm. Pharmacol.

 

Vol. 6  No. 5
 

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Medjedovic S

Djuric DM

 

 

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African Journal of Pharmacy and Pharmacology Vol. 6(5), pp. 283 - 293, 8 February, 2012

DOI: 10.5897/AJPP10.387

ISSN 1996-0816 ©2012 Academic Journals

 

 

Full Length Research Paper

 

Prognostic value of N-terminal pro-B-type natriuretic peptide in patients with non-ST-segment elevation acute coronary syndromes

 

Svetlana Medjedovic1, Vladimir Jakovljevic2*, Dusica Djordjevic2, Danijela Randjelovic1, Zoran Koprivica3, Natasa Petronijevic4, Nebojsa Tasic5, Miroslav Pavlovic1, Zarko Vucinic6, Zvonko Sundric1 and Dragan M. Djuric7

 

1Institute for Aviation Medicine, Military Medical Academy, Belgrade, Republic of Serbia.

2Department of Physiology, Faculty of Medicine, University of Kragujevac, Kragujevac, Republic of Serbia.

3Health Centre, Gornji Milanovac, Republic of Serbia.

4Institute of Biochemistry, School of Medicine, University of Belgrade, Belgrade, Republic of Serbia.

5Institute of Cardiovascular Disease Dedinje, School of Medicine, University of Belgrade, Republic of Serbia.

6Clinic for Cardiology, Military Medical Academy, Belgrade, Republic of Serbia.

7Institute of Physiology “Richard Burian“, School of Medicine, University of Belgrade, Belgrade, Republic of Serbia.

 

*Corresponding author. E-mail: drvladakgbg@yahoo.com. Tel: +381 34 34 29 44.

Fax: + 381 34 30 68 00/ext: 112.

 

Accepted 27June, 2011.

 

 Abstract

 

The aim of this study was to compare the predictive value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and other frequently used biomarkers, such as creatine kinase (CK), creatine kinase-mB (CK-MB), cardiac troponin T (cTnT) and C-reactive protein (CRP) for systolic and diastolic left ventricular function (SLVF and DLVF), and adverse coronary events in patients with non-ST-segment elevation acute coronary syndrome. The research was carried out within a group of 75 patients. Patients with referent NT-proBNP levels (<14.75 pmol/l) had significantly less compromised SLVF as compared to patients with elevated NT-proBNP levels. Initially determined levels of NT-proBNP showed statistically significant correlations with all parameters of left ventricular function measured on the control examination, while other biomarkers, except creatine kinase, did not. High sensitivity and negative predictive value of NT-proBNP for SLVF (up to 95.1 and 88.9%, respectively) and adverse coronary events (up to 100.0%) was found. These results make us assume that NT-proBNP may be the single best predictor of left ventricular function in patients with non-ST-segment elevation acute coronary syndromes.

 

Key words: Cardiovascular disease, serum biomarkers, left ventricular function, myocardial infarction, unstable angina.

 

 

 

 


 

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