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Full Length
Research Paper
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A
meta-analysis of the efficacy and safety of arotinolol in
the treatment of Chinese patients with essential
hypertension
Du Bing1#，Cui
Wen-peng2#，Xu
Guo-liang1, Sun Guo-qiang1, Wu
Guo-dong1, Qu Rui1,
Lin Shu-mei1,
Liu Yun-yang1, Qin Ling1*
1Department
of Cardiology, the second part of First Hospital, Jilin
University, Changchun, China.
2Department
of Nephrology, Second Hospital, Jilin University, Changchun,
China.
*Corresponding author. E-mail:
qinling1958@yahoo.com.cn. Tel: +86 15843073203; Fax: +86
0431 84841049.
#These
authors contributed equally to this work and should be
considered co-first authors.
Accepted 8 September, 2011 |
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Abstract |
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Arotinolol had been used for treatment of
essential hypertension. We conducted a
meta-analysis to compare the efficacy and safety
of arotinolol with other antihypertensive drugs
in treating essential hypertension. Medical
databases and review articles were screened with
prespecified criteria for randomized controlled
trials that reported the effects of and adverse
reactions to arotinolol and other
antihypertensive drugs in treating essential
hypertension. Literature identified
meta-analysed using RevMan4.2. Methodology
quality of the selected studies was conducted
using a Jadad scale. The results were that a
total of 176 articles had been found of which 6
were finally included for meta-analysis. The
meta-analysis compared the efficacy and safety
of arotinolol with other common antihypertensive
drugs, including enalapril, felodipine,
imidapril, cilinidipine, metroprolol and
atenolol. Results indicated that there were no
evidence for differences in safety and efficacy.
Homogeneity test, χ2 = 4.41, df = 7,
P = 0.73 (efficacy); χ2 = 2.96, df =
4, P = 0.56 (safety); combined test, Z = 0.64 (P
= 0.52), OR = 1.17, 95% confidence interval (CI)
(0.72, 1.85) (efficacy); Z = 1.75 (P = 0.08), OR
= 0.60, 95% CI (0.34, 1.06) (safety). There was
no significant difference in efficacy and safety
between arotinolol and other common
antihypertensive drugs used for treating
essential hypertension.
Key words:
Meta-analysis, arotinolol, essential hypertension, efficacy,
safety.
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