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Full Length
Research Paper
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Possible mode of action of Cissus quadrangularis in
experimental induced nociception in mice
A. H. M. Vishwantha Swamy*, B. C. Koti, A. H. M. Thippeswamy,
A. Jaffar Sadiq, D. M. Praveen and Mahesh Patil
Department of Pharmacology, KLEU’s College of Pharmacy,
Hubli-580031.Karnataka, India.
*Corresponding author. E-mail:
vmhiremath2004@yahoo.com
Accepted 23 March, 2012 |
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Abstract |
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The methanolic root extract of Cissus
quadrangularis L. (CQ) belongs to the
family Vitaceae and was evaluated for its
antinociceptive activity by radiant heat and
acetic acid induced pain models in mice, at four
different dose levels of 10, 50, 100 and 200
mg/kg by intraperitoneal (i.p.) route. The
results obtained in the writhing test showed
that CQ at a dose levels of 50, 100, 200 mg/kg
significantly inhibited the acetic acid-induced
writhing in mice in a dose dependant manner
decreasing the writhes by 84.23% at a dose of
200 mg/kg. In the tail-flick assay, the results
obtained with the intraperitoneal administration
of CQ at dose levels of 50, 100, 200 mg/kg i.p.
demonstrated significant antinociceptive
activity increasing the latency of tail flick in
mice comparable to the control drug, pentazocine
(10 mg/kg i.p.).
The intraperitoneal administration of naloxone
along with CQ decreased the latency of tail
flick in mice, which suggest that CQ contain
antinociceptive substances which appear to be
related to the activation of opioid receptors.
The results showed that the methanolic extract
of C. quadrangularis L. had excellent
antinociceptive activity.
Key words:
Cissus quadrangularis,
antinociceptive, spinal algesia. |
