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Full Length
Research Paper
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Pharmacokinetics of oral administration of 2, 3, 5,
4'-tetrahydroxystilbene-2-O-β-d-glucoside from Polygonum
multiflorum in beagle dogs
Jianxin Chen, Huihui Zhao, Liangtao Luo, Chenglong Zheng,
Fugang Wang, Qi Shi, Bing Liu and Wei Wang*
Beijing University of Chinese Medicine, 11 Bei San Huan Dong
Lu, ChaoYang District, Beijing 100029, P. R. China.
*Corresponding author. E-mail:
wangwei@bucm.edu.cn.
Tel: +86-10-64286283. Fax: +86-10-64286283.
Accepted 20 March, 2012 |
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Abstract |
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Pharmacokinetics studies of traditional Chinese
medicine are increasingly showing its importance
and necessity. In this study, we aim to
determine the pharmacokinetics of oral
administration of
2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside
(SBGC) from Polygonum multiflorum or
P. multiflorum extracting in Beagle dogs.
Beagle dogs were fed with
SBGC (2.0, 1.5 and 1.0 g/kg body weight) or
P.
multiflorum
extracts
(2.5 g/kg body weight) by oral gavage. We then
examined pharmacokinetic parameters, including
the area under the plasma concentration-time
curve, maximum plasma concentration, time to
maximum plasma concentration, half-life of
absorption, half-life of distribution, half-life
of elimination, and average drug retention time
in the blood. The basic pharmacokinetic
characteristics were similar between these two
situations. When Beagle dogs were fed with P.
multiflorum extracts, SBGC was absorbed and
distributed faster, but the elimination speed
remained at the same level.
The current findings provide a clear guidance
for the clinical application of P.
multiflorum.
Key words:
Pharmacokinetics, beagle dogs, Polygonum multiflorum,
2,3,5,4'-tetrahydroxystilbene-2-O-β-d-glucoside. |
