Begum et al. In vitro enzyme inhibition activities of Myrtus communis L.. Afr. J. Pharm. Pharmacol. 15 April, 2012

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Afr. J. Pharm. Pharmacol.

Vol. 6 No. 14

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Full Length Research Paper

In vitro enzyme inhibition activities of Myrtus communis L.

Seema Begum¹, Mumtaz Ali¹, Husna Gul¹, Waqar Ahmad², Sultan Alam¹, Momin Khan³, Mir Azam Khan² and Manzoor Ahmad^1,4

¹Department of Chemistry, University of Malakand, Chakdara, Dir (L), Khyber Pukhtoonkhwa, Pakistan.

²Department of Pharmacy, University of Malakand, Chakdara, Dir (L), Khyber Pukhtoonkhwa, Pakistan.

³Saidu Group of Teaching Hospital, Saidu Sharif, Swat, Khyber Pukhtoonkhwa, Pakistan.

⁴Swaziland Institute for Research in Traditional Medicine: Medicinal and Indigenous Food Plants, University of Swaziland, Private Bag 4, Kwaluseni, Swaziland.

*Corresponding author. E-mail: manzoorhej@yahoo.com. Tel: 00923333586144

Accepted 28 March, 2012

Abstract

The crude methanolic extract and chloroform, ethyl acetate and n-butanol fractions of Myrtus communis L. were examined as inhibitors of acetylcholinesterase, butyrylcholinesterase and lipoxygenase. A significant enzyme inhib ition activity (81 to 91%) was shown by the crude methanolic extract and its fractions against acetylcholinesterase, while high to outstanding enzyme inhibitory activity (72.5 to 99%) was shown against butyrylcholinesterase. The crude methanolic extract and its various fractions also demonstrated significant activity (79 to 94.5%) against lipoxygenase.

Key words: Myrtus communis L., acetylcholinesterase, butyrylcholinesterase, lipoxygenase, inhibition.

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