Synthesis and characterization of porous hollow silica
nanoparticles using ZnSe core as template for drug delivery
Soodabe Gharibe1*, Shahrara Afshar2
and Leila Vafayi1
Branch, Islamic Azad University, Firoozkooh,
of Chemistry, Iran University of Science and Technology,
16846-13114 Tehran, Iran.
*Corresponding author. E-mail:
firstname.lastname@example.org. Tel: +98 221 622 4091. Fax:
+98 221 622 5994.
Accepted 4 November, 2011
In this contribution, porous hollow silica
nanoparticles using inorganic nano sized ZnSe as
template were prepared. The hydrothermal method
was used to synthesize pure ZnSe nanospheres
material. The ZnSe/SiO2 core-shell
nanocomposites were prepared using a simple
sol-gel method successfully. The hollow silica
nanostructures were achieved by selective
removal of the ZnSe core. The morphology,
structure and composition of the product were
determined using powder X-ray diffraction (XRD),
emission scanning electron microscopy (SEM),
transmission electron microscopy (TEM) and
Fourier transform infrared spectroscopy (FT-IR).
The results demonstrated clearly that the pure
ZnSe nanoparticles are in a spherical form with
the average size of 30 nm and correspond with
zinc blend structure. The porous hollow silica
nanoparticles obtained were exploited as drug
carrier to investigate in vitro release
behavior of cefalexin in simulated body fluid (SBF).
UV-Visible spectrometry was carried out to
determine the amount of cefalexin entrapped in
the carrier. Cefalexin release profile from
porous hollow silica nanoparticles followed a
three stage pattern and indicated a delayed
Hollow silica nanoparticles, core-shell, ZnSe, drug delivery,
transmission electron microscopy (TEM).