Full Length Research Paper

Effect of Helicobacter pylori infection on the lipid, lipoproteins, apolipoprotein-A1, lipoprotein (a) and apolipoprotein-B in patients with gastritis

Mohammad Hassan Khadem Ansari^1*, Mir-davood Omrani², Biet Sayyah¹ and Sina Khadem Ansari³

¹Department Clinical Biochemistry, Urmia Medical School, Urmia, Iran.

²Department of Genetic, Urmia University of Medical Sciences, Urmia, Iran.

³Medical Faculty of Osmangazi University, Turkey.

*Corresponding author. E-mail:mhansari1@hotmail.com. Tel: +98 (441) 2223675.

Accepted 7 October, 2009

   Abstract

There are evidences of relationship between chronic infections of Helicobacter pylori (H. pylori) and gastritis in some previous studies. The gastritis caused by H. pylori leads to a change in serum levels of lipids, lipoproteins, apolipoprotein-A1 (Apo-A1), apolipoprotein-B (Apo-B) and lipoprotein-a (Lp(a)). These changes will lead to thrombogenesis and other cardiovascular diseases. The aim of this study is to find out a correlation between lipids profiles and helicobacter gastritis. In this study 20 males and 20 females in age between 30 - 50 years old with gastritis resulting from H. pylori were chosen as patients group. Patients serum levels of Apo-A1, Apo-B and Lp(a) as well as total cholesterol, triglyceride, High density lipoprotein (HDL-C) and Low density lipoprotein (LDL-C) were measured. As control, 26 persons with other types of gastritis (helicobacter negative), without having diseases such as: diabetes, hyperlipidemia, renal failure, liver diseases, with similar age ranges were chosen. Mean levels of total Cholesterol, triglyceride, LDL-C, ApoB lipoprotein and Lp (a), as well as total Cholesterol/HDL ratio and LDL-C/HDL-C ratio in patients with gastritis resulted by H pylori were significantly increased compared to control groups. In addition HDL-C and Apo- A1 lipoprotein were decreased significantly. Therefore it was possible to conclude that H. pylori infection can cause lipid metabolism disorders that may act as risk factors for cardiovascular diseases.

Key words: Gastritis, H. pylori, lipids, lipoprotein, Apo lipoprotein, Lp (a).