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African Journal of Biochemistry Research Vol.
1 (6), 117-123, November 2007
ISSN 1996-0778
© 2007 Academic Journals
Full Length Research Paper
Protective effect of
betaine on changes in the levels of protein, glycoproteins and amino
acids in isoprenaline-induced myocardial infarction in rats
B. Ganesan1,2, R. Rajesh1,3
, R. Anandan 2,* and N. Dhandapani1,4
1Vinayaka Mission University, Ariyanoor, Salem-636308, Tamil
Nadu, India.
2Biochemistry and Nutrition Division, Central Institute of
Fisheries Technology, Matsyapuri (PO), Cochin-682029, India.
3Quality Assurance and Management Division, Central Institute
of Fisheries Technology, Matsyapuri (PO), Cochin-682029, India.
4Department of Pharmaceutical Chemistry, R.V.S College of
Pharmaceutical Sciences, Sulur, Coimbatore-641402, India.
*Corresponding author. E-mail:
kranandan@rediffmail.com,Tel:
+91-484-2666845. Fax: +91-484-2668212.
Accepted 1 November, 2007
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The protective effect of
betaine administration on changes in the levels of protein,
glycoproteins and amino acids was studied in isoprenaline-induced
myocardial infarction in rats as an animal model of myocardial
infarction in man. Oral pre-treatment with betaine significantly
(P<0.05) attenuated the isoprenaline-induced rise in the levels of
troponin-T and creatine phosphokinase (CPK). Oral supplementation of
betaine also significantly (P<0.05) counteracted the isoprenaline-induced
alterations in the levels of amino acids (taurine, aspartate, glutamate,
arginine, hydroxy proline and homocysteine), protein content,
glycoprotein components (hexose and hexosamine) and lipid peroxidation
in the heart tissue and maintained their levels comparable to that of
control animals. The results indicated that the overall cardioprotective
effect of betaine was probably related to its ability to strengthen the
myocardial membrane by its membrane stabilizing action or to a
counteraction of free radicals by its antioxidant property.
Key words: Betaine,
myocardial infarction, isoprenaline, glycoproteins, lipid peroxidation. |
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