African Journal of Biotechnology
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African Journal of Biotechnology Vol. 2 (9), pp. 317-321, Semtember 2003 ISSN 1684-5315 © 2003 Academic Journals
Full
Length Research Paper
In vitro trypanocidal effect of methanolic extract of some Nigerian savannah plants
S.E. Atawodi1*, T. Bulus1, S. Ibrahim1, D.A. Ameh1, A.J. Nok1, M. Mamman2, M. Galadima3
1Biochemistry Department, Ahmadu Bello University, Zaria, Nigeria. 2Veterinary Physiology and Pharmacology Department, Ahmadu Bello University, Zaria, Nigeria. 3Microbiology Department, Ahmadu Bello University, Zaria, Nigeria.
*Correspondence author; E-mail: atawodi_se@yahoo.com, Tel: +234-69-550 837.
Accepted 10 August 2003
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| Abstract | |||||
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Methanol extracts from twenty three plants harvested from the Savannah vegetation belt of Nigeria were analyzed in vitro for trypanocidal activity against Trypanosoma brucei brucei and Trypanosoma congolense at concentrations of 4 mg/ml, 0.4 mg/ml and 0.04 mg/ml. Extracts of Khaya senegalensis, Piliostigma reticulatum, Securidaca longepedunculata and Terminalia avicennoides were strongly trypanocidal to both organisms while extracts of Anchomanes difformis, Cassytha spp, Lannea kerstingii, Parkia clappertioniana, Striga spp, Adansonia digitata and Prosopis africana were trypanocidal to either T. brucei brucei or T. congolense. These findings provide evidence of the effects of some plants in the traditional management of trypanosomiasis.
Key words: Savannah, medicinal plants, trypanocidal effects, trypanosomiasis, trypanosome, in vitro model.
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