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Full Length
Research Paper
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Flavonoids
from mulberry leaves by microwave-assisted extract and
anti-fatigue activity
Wei Li
1*, Tao Li2 and Keji Tang1
1Dezhou
University, Dezhou, Shandong Province, 253023, People’s
Republic of China.
2China
West Normal University, Nanchong, Sichuan Province, 637002,
People’s Republic of China.
*Corresponding author. E-mail: liweidezhouuv@126.com,
liweidezhouuv@sina.com.
Tel.: +86-0534-2969004.
Accepted 1 August, 2009 |
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Abstract |
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Flavonoids from mulberry leaves (FML) were extracted using
microwave-assisted extraction method (MAE). Several correlation
factors were studied to optimise conditions at laboratory scale.
The research results indicated that the optimal extraction
parameters are as follows: ethanol concentration is 60%,
material/solvent ratio is 1:15, microwave irradiation power is
560 W and irradiation time is 5 min. FML were tested in mice
weight-loaded swimming model. Both high-dose and middle-dose of
FML could obviously prolong the swimming endurance time, and had
active effects on the serum blood urea nitrogen (BUN), hepatic
glycogen and blood lactic acid levels in mice. The above results
suggest that appropriate dose of FML possessed an anti-fatigue
activity in mice.
Key words:
Flavonoids, mulberry leaves, microwave-assisted extract,
anti-fatigue. |
