|
Cytogenetic analysis of benign prostate hyperplasia (BPH)
and prostate cancer (PC) patients from Tamil Nadu, South
India
V. Balachandar*, S. Mohanad Devi, B. Lakshman Kumar, R.
Sangeetha, P. Manikantan, K. Suresh and K. Sasikala
Human
Genetics Laboratory, Department of Zoology, School of Life
Sciences, Bharathiar University,
Coimbatore Tamilnadu, India.
*Corresponding author. E-mail: geneticbala@yahoo.com.
Accepted
28 March, 2008 |
|
Benign prostate hyperplasia (BPH; n = 63) and prostate cancer
(PC; n = 18) patients were ascertained on the basis of
prostate specific antigen (PSA) levels from the hospitals
located in Tamil Nadu, South India. The patients were
analyzed for chromosomal aberrations (CA) using cultured
peripheral leucocytes. The patients were grouped into two
age group (group I: ≥ 50 yrs; group: II ≤ 51 yrs. Deletions,
translocations, inversions and mosaics were the major CA
observed in both the groups of chromosome 1, 2, 3 6, 7, 9,
16, 22, and X were the affected chromosome in PC patients
and in BPH patients 1, 7 and 16 and Y chromosomes were
affected. Chromosomes 1, 7 and 16 were observed in both
groups of patients. Group II patients showed higher number
of CA than group I. Group comparisons were statistically
significant (P<0.001).
Key words: Prostrate cancer patients, benign prostate
hyperplasia, chromosomal aberrations, prostate specific
antigen, peripheral blood lymphocytes. |
