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Sci. Res. Essays


Vol. 3 No.
2



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Ibezim EC

Odoh UE

 
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Scientific Research and Essays Vol. 3 (2), pp. 046–050, February 2008

ISSN 1992- 2248  © 2008 Academic Journals  

 

 

Full Length Research Paper

 

The role of ginger starch as a binder in acetaminophen tablets

 

Ibezim, E.C1., Ofoefule, S.I2., Omeje, E.O3*, Onyishi V.I2 and Odoh, U. E4.

 

1Department of Pharmaceutics, Faculty of Pharmaceutical Sciences

University of Nigeria, Nsukka, Nigeria.

2Department of Pharmaceutical Technology and Industrial Pharmacy,

Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.

3Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Nigeria.

4Department of Pharmacognosy, Faculty of Pharmaceutical Sciences

University of Nigeria, Nsukka, Nigeria.

 

*Corresponding author. E-mail: winnomeje@yahoo.com. Phone: +234-80-354-95441.

 

Accepted 10 January, 2008

 
   Abstract
 

The rhizomes of ginger, Zingiber officinale (Roscoe; Zingiberacea) has been reported to contain up to 56.0% starch. The starch was extracted from the fresh rhizomes, evaluated for relevant properties and used as a binder to acetaminophen tablets at concentrations of 2.0 - 8.0% w/w. The tablets were evaluated for hardness, friability, weight uniformity, disintegration and dissolution profiles. Acetaminophen tablets containing gelatin as standard binder were produced and assessed comparatively. Results obtained indicate that ginger starch performed as good as gelatin as a binder to acetaminophen tablets.

 

Key words: Ginger, Zingiber officinale, binder, zingiberacea, acetaminophen.

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