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Diclofenac induced toxic manifestations on adjuvant induced
arthritic rats pheripheral and reproductive organ of male
wistar rats rattus norvegicus
Sambandam Subramanian
Department of Biotechnology, International Research
Institute for the Deaf (IRID), an Institute under Acoustical
Foundation for Education and Charitable Trust (AFECT),
Chennai, India. E-mail:
sambandam.subramanian@gmail.com.
Accepted
5 May, 2009 |
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Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are the most
frequently prescribed therapeutic agents, used for the
treatment of rheumatic diseases, because they have
analgesic, antipyretic and anti- inflammatory actions.
Diclofenac (Voltaren) is a well-known member of the acetic
acid family of NSAIDs, used to reduce inflammation and pain
associated with arthritis osteoarthritis, and ankylosing
spondylitis. There is considerable interest in the toxicity
of diclofenac because of its clinical use and for the study
of the mechanisms of nephrotoxicity, renal dysfunction,
hematotoxicity and hypersensitivity reactions. In the
present study we have reported the basic metabolites and
activities of enzymes were studied in different tissues
against adjuvant and diclofenac sodium treatment. The change
due to the adjuvant treatment was attributed to the
inflammation associated changes and the further alteration
in diclofenac sodium was implicated to its toxic
manifestation, besides the drug side effect is caused by
metabolic idiosyncrasy.
Key words:
Inflammation, adjuvant arthritis, metabolites, enzymes. |
