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Full Length Research Paper
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Prevention of renal toxicity from lead exposure by oral
administration of Lycopersicon esculentum
Salawu Emmanuel O.1*, Adeleke Adeolu A.1,
Oyewo Oyebowale O.2, Ashamu Ebenezer A.2,
Ishola Olufunto O.1, Afolabi Ayobami O.1
and Adesanya Taiwo A.3
1Department
of Physiology, Ladoke Agential University, Ogbomoso,
Nigeria.
2Department
of Anatomy, Ladoke Akintola University, Ogbomoso, Nigeria.
3Department
of Biochemistry, Ladoke Akintola University, Ogbomoso,
Nigeria.
*Corresponding author. E-mail:
seocatholic@gmail.com
or
seocatholic@yahoo.com. Tel.: (234) 08056916409 or
08060894636
Accepted 8 June, 2009 |
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Abstract |
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For decades, lead (Pb) has being known for its adverse
effects on various body organs and systems. In the present
study, the ability of Pb to lower renal clearance (RC), as
an index of renal function, was investigated and tomato (Lycopersicon
esculentum: source of antioxidants) paste (TP) was
administered orally to prevent the Pb’s adverse effects. 54
Sprague Dawley rats, randomly divided into 3 groups (A, B
and C) n = 18, were used for this study. Group A animals
served as the control and were drinking distilled water.
Group B and Group C animals were drinking 1% lead(II)acetate
(LA). Group C Animals were, in addition to drinking LA,
treated with 1.5 ml of
TP/day.
All treatments were for 8 weeks.
Mann–Whitney U-test
was used to analyse the results obtained. The results of
this study showed that Pb caused a significant reduction in
the weight gain, 24 h urine volume, RC, plasma and tissue
superoxide dismutase (SOD) and catalase (CAT) activities,
but a significant increase in plasma and tissue
malondialdehyde (MDA) concentration. Administration of TP,
however, prevented these Pb’s adverse effects. These
findings lead to the conclusion that oral administration of
TP prevents Pb’s adverse effects on the kidney mainly by
preventing oxidation.
Key words:
Renal clearance, tomato, lead, Lycopersicon esculentum,
heavy metals, oxidative stress. |
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