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Fluoride and thyroid
function in children in two villages in China
Quanyong Xiang1*, Liansheng Chen 1,
Youxin Liang2, Ming Wu1 and Bingheng Chen2
1Jiangsu
Province Center for Disease Control and Prevention, 172
Jiangsu Road, Nanjing 21009, P. R. China.
2School
of Public Health, Fudan University (formerly Shanghai
Medical University), 138 Yixueyuan RD, Shanghai (200032),
China.
*Corresponding author.
E-mail:
quanyongxiang@yahoo.com.cn.
Tel: 86-25-83759469. Fax: 86-25-83759411.
Accepted
1 September, 2009. |
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Eighty two children, aged 8 - 13 years old, from Wamiao
village (severe endemic fluorosis area), from Xinhuai
village (nonendemic fluorosis area) were 88 (as a control
group), were recruited in this study. The prevalence of
dental fluorosis (DF) were 85.37% (Wamiao) and 6.82%
(Xinhuai) in two village’s children respectively; drinking
water fluoride (F-) in children’s household
shallow well from 0.62 - 4.00 mg/L in Wamiao and 0.23 - 0.76
mg/L in Xinhuai; serum total triiodothyronine (TT3), total
thyronine (TT4), thyroid-stimulating hormone (TSH) were 1.47
±
0.28 and 1.47 ±
0.33 ng/mL, 9.67 ±
1.76 and 9.22 ±
2.54 mg/dL,
3.88 ±
2.15 and 2.54 ±
2.07 mIU/mL
in two villages children respectively. The prevalence of DF,
drinking water F-, serum TSH in Wamiao village
was significantly higher than that in Xinhuai village. As
the children in Wamiao village were divided into different
subgroups according to their severity of DF, serum TT3 and
TSH showed significant difference in different groups. The
results in this study confirmed that the high F-
exposure can caused functional abnormalities of thyroid, and
the different severity degree of DF may be relation to
significant deviation in the serum levels of thyroid
hormone.
Key words:
Thyroid function, fluoride, dental fluorosis.. |
