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Evaluation
of some cytokines in Iraqi patients with Kala-azar
Yassir M.
K. Al-Mulla Hummadi
College of Pharmacy, Al-Mustansiriyah University, Hay Al-Qadisiyah,
P. O. Box 14070, Baghdad-Iraq.
*Corresponding author. E-mail:
yassir.almullahummadi@y-mail.com.
Accepted 21 January, 2010 |
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This study was carried out to investigate some cytokines
(INF-g, IL-10, TNF-a)
on blood samples of Iraqi children with Visceral
leishmaniasis (VL) before and during treatment with
stibogluconate and healthy people serving as control, using
ELISA kits. Samples were confirmed parasitologically by bone
marrow smears. The results of cytokine showed that there
were significant increases in the levels of all the
investigated cytokines (INF-g,
IL-10, TNF-a)
in the sera of patients with VL during active disease in
comparison with the control group. On the other hand,
patients after treatment showed a dramatic and progressive
decline in serum levels of all the tested cytokine during
the whole period-21 days- of therapy. These declines were
started from day-7 to go back to the normal or comparable to
the level of healthy controls after 21-days.
Key
words:
Visceral leishmaniasis, cytokines, ELISA, INF-g,
IL-10, TNF-a,
stibogluconate. |
