Lee et al.Antibacterial effects of S-(-)-tulipalin B isolated from Spiraea thunbergii Sieb. on Escherichia coli, a major food borne pathogenic microorganism. J. Med. Plants Res.

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J. Medicinal Plant Res

Vol. 2 No. 3

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Lee J

Park D

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Journal of Medicinal Plants Research Vol. 2 (3), pp.059–065, March2008

Full Length Research Paper

Antibacterial effects of S-(-)-tulipalin B isolated from Spiraea thunbergii Sieb. on Escherichia coli, a major food borne pathogenic microorganism

Jiyoung Lee¹, Jongsung Lee¹, Jihee Lim¹, Sanghee Sim² and Deokhoon Park^1*

¹Biospectrum Life Science Institute, SK Ventium 101-701, #522 Dangjung Dong, Gunpo City, Gyunggi Do, Rep. of Korea.

²School of Biotechnology, Yeungnam University, Gyeongsan City, Gyeongsangbuk Do, Republic of Korea.

*Corresponding author. E-mail: pdh@biospectrum.com

Accepted 8 February,2008

Abstract

The crude ethanol extract of the leaves of Spiraea thunbergii Sieb. (Rosaceae) showed antibacterial activity against a food borne pathogen, Escherichia coli. Bioactivity-guided separation led to the isolation of a butyrolaton, 1(S-(-)-tulipalin B). The structure was determined from the interpretation of spectroscopic data (UV, MS, and NMR). The minimal inhibitory concentration (MIC) of compound 1 against E. coli was found to be 100/ml. In addition, we found the possibility that a methylene group may operate as a key factor in the antibacterial activities of compound 1 and the hydroxyl group may exert a synergistic effect with the methylene group.

Key words: Spiraea thunbergii Sieb., antibacterial activity, butyrolactones, S-(-)-tulipalin B, Escherichia coli.

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