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  J. Medicinal Plant Res

 

  Vol. 2 No. 1
 

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  articles by:
 

  Elrahman AOF

  Galal M


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Journal of Medicinal Plants Research Vol. 2 (1), pp. 001–004, January 2008

ISSN 1996-0875 © 2008 Academic Journals  

   

 

Full Length Research Paper

 

  
 

Toxicopathological effects of Guiera senegalensis extracts in wistar albino rats

 

Azza, O. Fatih Elrahman1, Afaf, I. Abuelgasim1 and Galal, M2.

 

1Departement of Pathology, Faculty of Veterinary Medicine, University of Khartoum.

2Medicinal and Aromatic Plants Research Institute.

 

*Corresponding author. E-mail: azzasalih2007@yahoo.com

 

Accepted 17, December 2007
 
     
 

Abstract

  
     
 

Toxicity of methanolic and water extracts of the plant Guiera sengalensis has been tested on rats. The methanolic extract was injected intramuscularly while the water extract was given orally. Rats receiving 1000 and 500 mg/kg/day of the methanolic extract died within one week. The 250 mg/kg/day dose resulted in enlargement of the liver and kidneys, although body weights of the treated rats were not significantly different from the control. Alterations of haematological and serological parameters were evident. The effect of water extract was less marked compared to that of methanolic extract. Treatment with G. senegalensis resulted in endotheliotoxicity, hepatonephropathy and pancreatic hyperplasia.  

 

Key words: Guiera sengalensis, toxicology, pathology.

  

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