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Journal of Medicinal Plant Research Vol. 1 (5), 109 - 112, December 2007
ISSN 1996-0875
© 2007 Academic Journals
Full Length Research Paper
Embriofetotoxic effect and offspring
postnatal development exposed to hydroalcoholic fraction extract of
Cissus sicyoides L.
during wistar rats
pregnancy
E. R. Almeida*1, J. R. G.
Oliveira1, F. R S Lucena1, C. V. N. S. Silva1, R. P. F. Soares2, J. B. Cavalcanti2
and G. B. L. Couto2
1Laboratory
of Evaluation of Psychobioactive Drugs and its Toxicology of Department
of Antibiotics, Brazil.
2Department
of Odontology, Federal University of Pernambuco, University Campus CEP
5067901. Recife Pernambuco, Brazil.
*Corresponding author. E-mail:
edvaldo.ra@gmail.com
Accepted
28, November 2007
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Cissus sicyoides L (Verbaceae) is popularly known by its antidiabetic
action. The hydroalcoholic extract effect in pregnant rats and its
offspring was evaluated through the following parameters: gestation
duration, number of younglings for hatch, maternal weight gain, postural
reflex, and day of eye’s opening and day of adult gait. The results
suggest that the CS does not exert any effect on the fertility index.
However, all doses (300, 600 and 1000 mg/ kg, i.p.) had promoted
alteration in the postural reflex, but did not have alteration over the
eye opening parameter, as well as, in the adult gait, which is an
important phase of neurological development for offspring. CS did not
modify the maternal body's temperature and animals’ ambulation had no
alteration in all periods. The CS promoted malformations in foetuses:
Such as: abdominal organs outside cavity, sindactly, and absence of
tail.
Key
words: Cissus sicyoides L, embryotoxicity, offspring, wistar rats. |
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