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  J. Med. Plants Res.

 

  Vol. 5 No. 31
 

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  articles by:
 

  Houcine B

  Boufeldja T


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 Journal of Medicinal Plants Research Vol. 5(31), pp. 6864–6868, 23 December, 2011

 ISSN 1996-0875 ©2011 Academic Journals

 DOI: 10.5897/JMPR11.1369  

 

 

Full Length Research Paper

Effect of saponosides crude extract isolated from Citrullus Colocynthis (L.) seeds on blood glucose level in normal and streptozotocin induced diabetic rats

 

Benmehdi Houcine1,3*, Azzi Rachid2, Djaziri Rabah2, Lahfa Farid2, Benariba Nabila2 and Tabti Boufeldja1

 

1Laboratory of LASNABIO, Department of Chemistry, University of Tlemcen 13000, Algeria.

2Laboratory of Antibiotic and Antifungal, Department of Biology, University of Tlemcen 13000, Algeria.

3Laboratory of Plant Resource Development and Food Security in Semi Arid Areas, South West of Algeria, BP 417, University of Bechar, Algeria.

 

*Corresponding author. E-mail: h_ben90@yahoo.fr. Tel: 0779517854. Fax: 002137815244.

 

Accepted 14 November, 2011
 

 Abstract
 

The effect of saponosides crude extract isolated from the seeds of Citrullus Colocynthis L. Schrad (Cucurbitaceae) on blood glucose level were investigated in normal and diabetic rats (streptozotocin induced). A single and non toxic dose (20 mg/kg bw) of saponosides crude extract were administrated to animals by intraperitoneal route. Lethal doses of saponosides crude extract in healthy rats (DL50 and DL100) were found to be 200 and 250 mg/kg bw, respectively. The results obtained from this study showed no change of glycaemia in normal rats. Whereas, in STZ-treated diabetic animals, the blood glucose level decrease significantly (p<0.05) to reach its normal value 48 h after administration of saponosides crude extract. This antihyperglycaemic effect was maintained during twenty six days after a unique intraperitoneal injection. This effect can be reproduced after return to the diabetic state. Saponosides instigate an antihyperglycaemic and sustainable action in STZ-diabetic rats.

 

Key words: Citrullus colocynthis L., antidiabetic, saponosides, streptozotocin, rats.

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