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Journal of Medicinal Plants
Research Vol. 5(4), pp.
490–494,
18 February, 2011
ISSN 1996-0875 ©2011 Academic
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Full Length Research Paper |
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Effect of
Peristrophe bicalyculata on lipid profile of P- 407-induced
hyperlipidemic Wistar rats
Abdulazeez Mansurah
Ahmadu Bello University, Zaria, Kaduna State, Nigeria. E-mail:
mabdulazeez2001@yahoo.com. Tel: +234-803-450-9063.
Fax: +234-69-551294.
Accepted 9 December, 2009 |
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Abstract |
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The effect of the ethanolic extract of the leaves of
Peristrophe bicalyculata on the lipid profile of
hyperlipidemic rats was determined. Male Wistar rats were
divided into two major groups; Group A, to determine the
phytopreventive effect of the plant extract and group B, to
determine its curative effect. Group A animals were administered
the extract ad libitum for 26 days prior to induction of
hyperlipidemia, while group B animals were administered the
extract ad libitum also, for 2 days, beginning two hours
after induction of hyperlipidemia. Atorvastatin was used as the
standard drug. Rats were made hyperlipidemic by intraperitoneal
injection of 1.0 g/kg poloxamer 407 (P-407) and blood samples
collected 48 h after administration of P-407. On the 28th
day, blood samples were collected to determine plasma lipid
profile and atherogenic risk predictor indices. The levels of
total cholesterol, LDL-cholesterol and triglycerides in animals
treated with the extract in both groups were significantly lower
(p < 0.05) than those in the hyperlipidemic control group; while
HDL-cholesterol level significantly increased. In most cases,
there were no significant differences in lipid levels of rats
administered the extract, especially at a higher dose, compared
to Atorvastatin. The Atherogenic risk predictor indices showed
that rats in the hyperlipidemic control group and those treated
to determine the curative effect of the extract were at risk of
atherosclerosis. In conclusion, this study has demonstrated the
phytopreventive, hypolipidemic and antiatherogenic effect of
P. bicalyculata.
Key words:
Peristrophe bicalyculata, poloxamer 407,
hyperlipidemia, atherogenic
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