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Journal of Medicinal Plants
Research Vol. 5(4), pp.
644–648,
18 February, 2011
ISSN 1996-0875 ©2011 Academic
Journals |
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Full Length Research Paper |
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Antimicrobial
evaluation of the interaction between methanol extract of the
lichen, Ramalina Farinacea (Ramalinacea) and Ampicilin
against clinical isolates of Staphylococcus Aureus
A. A. Agboke1* and C. O.
Esimone2
1Department
of Pharmaceutics and Pharmaceutical Technology, Faculty of
Pharmacy, University of Uyo, Akwa Ibom State, Nigeria.
2Department
of Bio-pharmaceutics and Pharmaceutical Microbiology, Faculty of
Pharmaceutical Sciences, Nnamdi Azikwe University, Akwa, Anambra
State, Nigeria.
*Corresponding author. E-mail:
ayoagboke@yahoo.com.
Accepted 8 November, 2010 |
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Abstract |
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Ampicillin is a member of the group of antibiotics called
penicillin otherwise known as B-lactam drugs; it is a selective
inhibitor of bacterial cell wall synthesis and therefore is
active against growing bacteria. Ampicillin is one of the most
widely prescribed antibiotics. It is considered as penicillin
and is a close relative of amoxicillin. Unlike penicillin,
ampicillin and amoxicillin can penetrate and prevent the growth
of certain types of bacteria, called gram-negative bacteria.
Ampicillin is used mainly to treat infections of the middle ear,
sinuses, bladder, kidney, and uncomplicated gonorrhea. It is
used intravenously to treat meningitis and other serious
infections. The activities of this antibiotic were in some cases
hindered by the
b-lactamase
producing resistant strains of Staphylococcus aureus.
Antimicrobial interaction screening of the methanol extract with
ampicillin, reveled that most of the combination ratio of
methanol extract and ampicillin shows synergism while few were
additive and no indifference and antagonism. This shows that in
the treatment of infections of S. aureus the combination
of the methanol extract of Lichen, Ramalina Farinacea and
ampicilin can be used together to enhance potency of the
ampicilin in some cases of infection by S. aureus.
Key words:
Antimicrobial interactions, Lichen, Ramalina farinacea,
ampicillin, Methanol extract, Staphylococcus aureus.
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