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Journal of Medicinal Plants
Research Vol. 5(18), pp.
4616–4620,
16 September, 2011
ISSN 1996-0875 ©2011 Academic
Journals |
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Full Length
Research Paper |
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Antidiabetic
antioxidant effect of Panax ginseng
Zakaria El-Khayat,
Jihan Hussein, Tahany Ramzy* and Magdy Ashour
Department of Medical Biochemistry, National Research Center
(NRC), Giza, Egypt.
*Corresponding author. E-mail:
tahany_adel@hotmail.
Accepted 8 June, 2011 |
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Abstract |
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This study was done to investigate the biochemical effect of
Panax ginseng C.A. Meyer on the diabetic rats. Sixty male albino
rats were divided into four groups (fifteen for each group)Normal control, normal treated, diabetic and treated
diabetic groups. Blood glucose, serum insulin, serum lipids
(cholesterol, triglycerides, HDL, LDL and VLDL-cholesterol) were
estimated. Also, serum interleukin - 6 (IL- 6) and tumor
necrosis factor alpha (TNF - α) were determined. Liver oxidant
malondialdehyde (MDA), liver antioxidants {glutathione
peroxidase (GPX) and superoxide dismutase (SOD)} were
determined. The mean values of blood glucose, cholesterol,
triglycerides, LDL and VLDL- cholesterol showed significant
decrease in treated diabetic group as compared to their values
in the diabetic group. Also, serum IL - 6 and TNF - α levels
were improved after treatment with ginseng. Liver antioxidants
were decreased in the diabetic group while they were
significantly increased after treatment with ginseng. We
concluded that Panax ginseng C.A. Meyer could be used safely as
antidiabetic antioxidant agent.
Key words:
Ginseng, diabetes, antioxidant, IL - 6, TNF - α. |
