Shahwar et al. Acetyl cholinesterase inhibition potential and antioxidant activities of ferulic acid isolated from Impatiens bicolor Linn.. J. Med. Plants Res.

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Vol. 4 No. 3

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Journal of Medicinal Plants Research Vol. 4(3), pp. 260–266, 4 February 2010

Full Length Research Paper

Acetyl cholinesterase inhibition potential and antioxidant activities of ferulic acid isolated from Impatiens bicolor Linn.

Durre Shahwar*, Shafiq Ur Rehman and Muhammad Asam Raza

Department of Chemistry, Government College University, Lahore, Pakistan.

*Corresponding author. E-mail: drdshahwar@yahoo.com. Tel: +92-3334566845. Fax: +92-42-99213341.

Accepted 29 December, 2009

Abstract

Ferulic acid was isolated from ethyl acetate extract of Impatiens bicolor Linn. and identified by X-ray analysis. The acetylcholine esterase inhibition, radical scavenging activity (DPPH scavenging assay) and FRAP assay were carried out on the compound. It was found that the effect of ferulic acid was strongly dose dependent i.e., 25 - 175 µg/ml in DPPH assay, 50 - 150 µg/ml in FRAP assay and 50 - 200 µg/ml in acetylcholine esterase inhibition assay. However, ferulic acid did not show significant change in acetylcholine esterase inhibition and antioxidant activity at high concentration.

Key words: Acetyl cholinesterase, FRAP, ferulic acid, Impatiens bicolor, medicinal plant.

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