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Journal of Medicinal Plants
Research Vol. 4(14), pp.
1365–1369,
18 July, 2010
ISSN 1996-0875 ©2010 Academic
Journals |
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Full Length Research
Paper |
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Comparative in vitro
trypanocidal activities of water and methanol extracts of
three parts of Khaya senegalensis on Trypanosoma
evansi
A. A. Adeiza1*, H. K. Makeri1 and
M. Mohammed2
1Department of Animal Health and Husbandry, College of Agriculture and Animal
Science, Ahmadu Bello University, P. M. B. 2134, Mando Road,
Kaduna, Nigeria.
2Department of Chemistry, College of Agriculture and Animal Science, Ahmadu
Bello University, P. M. B. 2134, Mando Road, Kaduna, Nigeria.
*Corresponding author. E-mail:
dearadeiza@yahoo.com.
Accepted
11 June, 2010 |
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Abstract |
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A comparative
phytochemical and in vitro studies of water and methanolic
extracts of three different parts of Khaya senegalensis, a plant
used by herbalists in Nigeria to treat helminthiasis and other
ailments revealed the presence of alkaloids, carbohydrates, tannins,
saponins, flavonoids, terpenes sugars, cardiac glycosides and
phlobatannins. At a dose of 20 mg/ml the water extract (leaf, stem bark
and root) immobilised Trypanosoma evansi the most at 25 min while
the methanol extract showed the most activity in the stem bark at 30
min. The results obtained with these crude extracts showed that K.
senegalensis is a potential source of trypanocidal drug/chemical
leads.
Key words:
Khaya senegalensis, Trypanosoma evansi, trypanocidal activity,
mando road, in vitro, water, methanolic. |
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