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  J. Med. Plants Res.

 

  Vol. 3 No. 9
 

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  articles by:
 

 Nkeh-Chungag BN

 Iputo JE

 


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Journal of Medicinal Plants Research Vol. 3 (9), pp. xxx–xxx, September 2009

ISSN 1996-0875 © 2009 Academic Journals  

   

 

Full Length Research Paper

 

  
 

Analgesic, anti-inflammatory and antiulcer properties of the extract of Uapaca guineensis (Euphorbiaceae)

 

Benedicta N. Nkeh-Chungag1*, Joel Romeo Temdie3, Constance Sewani-Rusike1, Yolande M Fodjo2, Joseph T Mbafor2 and J. E. Iputo1

 

1Department of Physiology, Faculty of Health Sciences, Walter Sisulu University, P.O. Box 1, Mthatha 5117, South Africa.

2Department of Organic Chemistry, Faculty of Science, P.O. Box 812, University of Yaoundé I, Cameroon.

3Physiology Unit, Department of Animal Biology and Physiology, Faculty of Science, P.O. Box 812, University of Yaoundé I, Cameroon.

 

*Corresponding author. E-mail: bnkehchungag@wsu.ac.za. Tel.: +27 47 502 2794. Fax: +27 47 502 2758.

 

Accepted 14 August, 2009
 
     
 

Abstract

  
     
 

Uapaca guineensis is an euphorbiaceae used traditionally for the management of pain and inflammation. The present study was aimed to investigate the analgesic, anti-inflammatory and anti-ulcer properties of the methanol extract of stilt root barks of U. guineensis in rats and mice. The analgesic properties of U. guineensis were investigated using the acetic acid writhing, hot plate as well as pressure-induced pain models. This was followed by a study of the anti-inflammatory properties of this plant using the carrageenan-induced acute inflammation method. The anti-ulcer test was done using high doses of both the extract and indomethacin. The extract showed significant (p < 0.05) reduction of pain induced by all three models of nociception. It also had significant (p < 0.05) anti-inflammatory properties and showed a non-ulcerative effect on gastric mucosa. Our results show that the methanolic extract of U. guineensis has both analgesic and anti-inflammatory properties and importantly does not corrode gastric mucosa.

 

Key words: Pain, inflammation, nociceptive, writhing, ulcer.

  

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