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  J. Med. Plants Res.

 

  Vol. 3 No. 9
 

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  articles by:
 

  Jackson C

  Nwoke V

 


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Journal of Medicinal Plants Research Vol. 3 (9), pp. 666–669, September 2009

ISSN 1996-0875 © 2009 Academic Journals  

   

 

Full Length Research Paper

 

  
 

In vitro evaluation of antimicrobial activity of combinations of nystatin and Euphorbia hirta leaf extract against Candida albicans by the checkerboard method

 

Clement Jackson1*, Akeem Agboke1 and Victor Nwoke2

 

1Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo, Nigeria.

2 University Teaching Hospitals, Port Harcourt, Nigeria.

 

*Corresponding author. E-mail: clementjackson2008@yahoo.com. 

Tel: 2348035499427, 23485660597.

 

Accepted 30 June, 2009
 
     
 

Abstract

  
     
 

The in vitro combined effects of Nystatin and methanol extract of leaves of Euphorbia hirta against clinical isolates of Candida albicans were investigated using the Checkerboard technique. The organism was susceptible to the extract with MIC of 25 mg/ml, while Nystatin had MIC of 0.165 mg/ml against C. albicans. Upon combination, some ratios showed synergistic while others indicated indifferent activities against the isolates. These results indicate that some combinations of the extract with nystatin could be synergistic in activity for some ratio combinations and indifferent for some others.

 

Key words: In vitro, nystatin, Euphorbia hirta, Candida albicans, checkerboard.

  

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