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Hypoglycaemic effect of Thymelaea hirsuta in normal
and streptozotocin-induced diabetic rats
Fadoua El Amrani, Abdeljalil Rhallab,
Tajelmolk Alaoui, Khalid El Badaoui and Said Chakir
UFR Environment and health,
Laboratory of Biochemical and Pharmacology. Faculty of
Science BP 11201 Zitoune, Meknès - Marocco.
*Corresponding author. E –mail:
fadoua_amrani@yahoo.fr.
Accepted 17 August, 2009 |
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The
present study has investigated the effect of oral administration of the
aqueous extract of Thymelaea hirsuta (T.hirsuta) on blood
glucose levels in normal, glucose-hyperglycemic and streptozotocin (STZ)-induced
diabetic rats.
In normal rats, single oral administration of T. hirsuta
lowered blood glucose levels significantly.
It
omitted significantly reduced the fasting glucose level in rats with
oral glucose (2 g/kg) induced hyperglycemia. In STZ-induced diabetic
rats, single oral administration of T. hirsuta also produced a
significant decrease of blood glucose levels.
The aqueous extract of T. hirsuta possesses both hypoglycaemic
and antidiabetic effects in normoglycaemic and streptozotocin-induced
diabetic rats.
This may indicate the ethnopharmacological reason of the use of T.
hirsuta in traditional medicine for treating diabetes.
Key
words:
Thymelae hirsute, hypoglycaemic activity, streptozotocin-induced
diabetic rats, aqueous extract, oral administration. |
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