Rezazadeh et al. Anti-inflammatory and anti–hyperalgesic activities of Stachys athorecalyx extracts on CFA-induced inflammation. J. Med. Plants Res.

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J. Medicinal Plant Res

Vol. 3 No. 5

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Rezazadeh SH

Kebryaeezadeh A

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Journal of Medicinal Plants Research Vol. 3 (5), pp. 368–376, May 2009

Full Length Research Paper

Anti-inflammatory and anti–hyperalgesic activities of Stachys athorecalyx extracts on CFA-induced inflammation

S. H. Rezazadeh¹, J. Zaringhalam²*, H. Manaheji² and A. Kebryaeezadeh³

¹Institute of Medicinal plants, ACECR, Tehran, Iran.

²Department of Physiology, Neuroscience Research Center, Shahid Beheshti University, M.C., Tehran, Iran.

³Department of Pharmacology and Toxicology, Tehran University of Medical Science, Tehran, Iran.

*Corresponding author. E-mail: jzaringhalam@yahoo.com.

jzaringhalam@sbmu.ac.ir. Tel.: +98 21 22416773. Fax: +98 21 22439971.

Accepted 25 April, 2009

Abstract

This study was aimed at investigating the possible anti-hyperalgesic and anti-inflammatory activities of pre-treatment and short term (6 days) administration of Stachys athorecalyx extracts during CFA-induced inflammation in male Wistar rats. Both methanolic and defatted extracts prepared from aerial parts of the plant were examined. The results showed dose related response in decreasing hyperalgesia and inflammation. The effective doses of both extracts were 100 mg/kg. The plant extracts were more potent in decreasing hyperplasia and inflammation compared with the standard drug (Indomethacin). By increasing the dose up to 200 mg/kg, there were no significant differences in pharmacological activities. Our results suggested that, aerial part of S. athorecalyx extracts suppress hyperalgesia and edema associated with acute and chronic CFA-induced inflammation.

Key words: Stachys athorecalyx, hyperalgesia, anti-inflammatory, CFA-induced inflammation.

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