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Antimicrobial, antioxidant
and anticancer activities of Thai local vegetables
S. Nanasombat1* and N. Teckchuen 2
1Department of Applied Biology, Faculty of Science, King Mongkut’s
Institute of Technology Ladkrabang, Bangkok, Thailand.
2Department of Chemistry, Faculty of Science, King Mongkut’s University of
Technology Thonburi, Bangkok, Thailand.
*Corresponding author. E-mail:
knsuree@kmitl.ac.th. Tel.: 66 2737 3000 ext. 6264. Fax:
66 2326 4354.
Accepted
18 May, 2009 |
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Thai local vegetables (20 species) were screened for their
antimicrobial and antioxidant activities. Methanolic extracts of
Cassia siamea, Garcinia cowa, Limnophila aromatica and
Polygonum odoratum exhibited strong antioxidant and antibacterial
activities. The sensitive bacteria to these extracts were Bacillus
cereus, Listeria monocytogenes and Staphylococcus aureus.
Among all plant extracts, the extract of P. odoratum had the
highest phenolic content and antioxidant activity with EC50
value of 315.35
mg
extract/mg DPPH (2,2-diphenyl-1-picrylhydrazyl). These plant extracts
were also tested for cytotoxicity against human oral epidermal carcinoma
(KB), breast adenocarcinoma (MCF-7) and small cell lung carcinoma
(NCI-H187). P. odoratum extract was moderately active against
MCF-7 (IC50 value of 6.01
mg/ml).
Major types of active compounds in P. odoratum extract were
identified by HPLC method. Flavonoids found in this plant were rutin,
catechin, quercetin, kaempferol and isorhamnetin. Among these compounds,
rutin was found in the highest amount (3.77% w/w dry extract).
Key words:
Polygonum odoratum, Cassia siamea, Garcinia cowa,
Limnophila aromatica, phenolic compounds, flavonoids. |
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