Longjun et al. Orthogonal test design for optimization of the extraction of polysaccharides from Lycium barbarum and evaluation of its anti-athletic fatigue activity. J. Med. Plants Res.

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J. Med. Plants Res.

Vol. 3 No. 5

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Jing L

Xiao Y

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Journal of Medicinal Plants Research Vol. 3 (5), pp. 433–437, May 2009

Full Length Research Paper

Orthogonal test design for optimization of the extraction of polysaccharides from Lycium barbarum and evaluation of its anti-athletic fatigue activity

Longjun Jing^{1, 2}*, Guowen Cui³, Qiang Feng¹ and Yuanshi Xiao¹

¹Qujing Normal University, Qujing, Yunnan Province, 655011, People’s Republic of China.

²Beijing Sport University Beijing, 100084, People’s Republic of China.

³Yuxi Normal University, Yuxi, Yunnan Province, 653100, People’s Republic of China.

*Corresponding author. E-mail: jinglongjun666@yahoo.cn. Tel.: +8613170662021.

Accepted 25 May, 2009

Abstract

Yield of polysaccharides from Lycium barbarum obtained by hot water and followed by precipitation with ethanol extraction through an orthogonal experiment were investigated to get the best extraction conditions. The results showed that the highest yield was obtained when extraction temperature, extraction time and ratio of solvent to raw material were 93°C, 4.3 h and 43, respectively. The anti-athletic fatigue activities of polysaccharides from Lycium barbarum were evaluated by the weight-loaded swimming model in mice. The results showed that polysaccharides from Lycium barbarum have noticeable anti-athletic fatigue effect on mice. It prolonged the weight-loaded swimming time, prevent the increase of blood lactic acid of mice after swimming and increase the content of hepatic glycogen of mice after swimming. The strongest effect on most biomarkers was seen with 60 mg/kg dose.

Key words: Polysaccharides from lycium barbarum, orthogonal experiment, anti-athletic fatigue, extraction.

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