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The discovery of novel compounds with pharmaceutical
application in cyanobacterias suggests that Blennothrix ganeshii
and Microcoleous lacustris Mexican species can be candidates for
the bioprocess of target compounds. The antispasmodic effect of hexane,
chloroform, methanol and water extracts of B. ganeshii and M.
lacustris were studied in vitro in guinea pig ileum against
three spasmogens; acetylcholine, histamine and barium chloride. In all
cases, the hexane extract produces a significant antispasmodic effect on
the contractions of the rat ileum induced by acetylcholine, histamine
and barium chloride. The inhibitory concentration for each was
determined. These results show that hexane extract of B. ganeshii,
and M. lacustris possesses both anticholinergic and
antihistaminic properties.
Key words:
Antispasmodic activity, Blennothrix ganeshii, cyanobacteria,
Microcoleous lacustris. |
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