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Antihyperglycaemic, antioxidative activities of a formulated
polyherbal drug MTEC (Modified) in streptozotocin-induced
diabetic rat
Kausik
Chatterjee, Kazi Monjur Ali, Chhanda Mallick and Debidas
Ghosh*
Department
of Bio-Medical Laboratory Science and Management, (Innovative
Programme Funded Department), Vidyasagar University, Midnapore-721102, West Bengal, India.
*Corresponding author.
E-mail:
debidas_ghosh@yahoo.co.in.
Accepted 2
June 2009 |
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Musa paradisiaca
belongs to the family of
Musaceae and is
distributed throughout India and Malaysia. The plant has medicinal value
as antidiabetic agent. Seeds of Tamarindus indica of
Caesalpiniaceae family used as traditional medicine for the management
of diabetes mellitus found throughout India. Eugenia jambolana an
evergreen tree of Myrtaceae family is used as traditional medicine for
the management of diabetes in India. Coccinia indica of
Cucurbitaceae family is distributed widely all over India and its
medicinal value as antidiabetic agent is well recognized. The diabetic
therapeutic efficacy of a formulated polyherbal drug (abbreviated form
MTEC), constituted with n-hexane fractions of the hydromethanol extract
of root of M. paradisiaca, seed of T. indica, seed of
E. jambolana and leaf of C. indica at specific ratio was
investigated in streptozotocin-induced diabetic rats.
Streptozotocin-induced diabetic state was confirmed here by the
monitoring of increased level of fasting blood glucose, decreased
glycogen level in liver and skeletal muscle along with elevation in the
activities of glucose-6-phosphatase and lactate dehydrogenase and
diminution in the activities of hexokinase as well as
glucose-6-phosphate dehydrogenase in liver, skeletal muscle and cardiac
muscle. Oral administration of MTEC (modified) at a dose of 100 mg/5 ml
of olive oil/Kg body weight daily to the diabetic rats significantly
(P<0.05) corrected fasting blood glucose level, glycogen contents of
liver and skeletal muscle along with said carbohydrate metabolic enzyme
activities in liver, skeletal and cardiac muscles in diabetic rat
towards the control levels. Diabetes mellitus induced oxidative stress
was also corrected significantly (P<0.05) by the treatment of this
polyherbal drug (modified MTEC) to the diabetic rat. Results of the
present study support the therapeutic potentiality of this polyherbal
drug MTEC for the management of diabetes.
Key words:
Antihyperglycaemic drug, polyherbal drug, diabetes mellitus, oxidative
stress, carbohydrate metabolic enzymes. |
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