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Glucose-6-phosphate dehydrogenase deficiency in blood donors
and jaundiced neonates in Osogbo, Nigeria
E. O. Akanni1*, B. S. A.
Oseni1, V. O. Agbona1, B. A. Tijani2,
E. Tosan3, E. E. Fakunle4 and V. O.
Mabayoje4
1Department
of Biomedical Science, College of Health Sciences, Ladoke
Akintola University of Technology, P. M. B. 4400, (OS
230001) Osogbo, Osun State, Nigeria.
2Department
of Haematology and Blood Transfusion, Ladoke Akintola
University of Technology Teaching Hospital, P. M. B. 5000,
(OS 230001) Osogbo, Osun State Nigeria.
3Medical
Laboratory Science Council of Nigeria, 8 Harvey Road, Yaba,
Lagos, Lagos State, Nigeria.
4Department
of Haematology and Blood Transfusion, Ladoke Akintola
University of Technology College of Health Sciences, P. M.
B. 4400, (OS 230001) Osogbo, Osun State, Nigeria.
*Corresponding author. E-mail:
olufemiakanni@yahoo.com.
Accepted 11 March, 2010 |
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A study on the prevalence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in blood donors and in
jaundiced neonates was carried out. 286 subjects consisting
of 200 blood donors and 86 jaundiced neonates were screened
for G6PD. Presence of G6PD and bilirubin levels (total and
conjugated) were determined in all the subjects. G6PD was
determined using two standard methods; methaemoglobin
reduction and fluorescent spots test. Total and
conjugated bilirubin levels were also determined in neonates
using Jendrassik and Groff method. Out of the 200 blood
donors tested for G6PD, 39 (19.5%) were G6PD deficient and
41 (47.7%) out of 86 jaundiced neonates were G6PD deficient.
There is a close association between the two methods used
for determining G6PD in blood donors and jaundiced neonates
as there was no significance difference “P < 0.05” between
the results obtained from the two methods. With G6PD
deficiency prevalence rate of 19.5% (39) in the blood
donors, and the attendant reduced life span of red blood
cells, this study therefore reveals the necessity of
including G6PD testing in the blood donors screening
criteria in the study area. Glucose-6-Phosphate Deficiency
is also revealed as a major cause of haemolytic episode in
neonates in the area.
Key words:
G6PD deficiency, prevalence, jaundiced neonates, blood
donors. |
