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Effect of paternal age on
aneuploidy rates in first trimester pregnancy loss
Vitaly A. Kushnir, Richard
T. Scott and John L. Frattarelli
1Department
of Obstetrics, Gynecology and Women’s Health, New Jersey
Medical School, MSB E-506, 185 South Orange Avenue, Newark,
NJ, 07101-1709, USA.
2Department
of Obstetrics, Gynecology and Reproductive Sciences, Robert
Wood Johnson Medical School UMDNJ, Division of Reproductive
Endocrinology and Infertility, New Brunswick, NJ.
Reproductive Medicine Associates of New Jersey, Morristown
NJ, USA.
*Corresponding author. E-mail:
vitalykushnir@yahoo.com. Tel: 973-972-5266,
801-580-1022. Fax: 973-972-4574.
Accepted
16 July, 2010 |
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A
retrospective cohort analysis of patients undergoing IVF
cycles at an academic IVF center was performed to test the
hypothesis that male age may influence aneuploidy rates in
first trimester pregnancy losses. All patients had a first
trimester pregnancy loss followed by evacuation of the
pregnancy and karyotyping of the abortus. Couples undergoing
anonymous donor oocyte ART cycles (n = 50) and 23 couples
with female age less than 30 years undergoing autologous
oocyte ART cycles were included. The oocyte age was less
than 30 in both groups; thereby allowing the focus to be on
the reproductive potential of the aging male. The main
outcome measure was the effect of paternal age on aneuploidy
rate. No increase in aneuploidy rate was noted with
increasing paternal age (<40 years = 25.0%; 40-50 years =
38.8%; >50 years = 25.0%). Although there was a significant
difference in the male partner age between oocyte recipients
and young patients using autologous oocytes (33.7 7.6 vs.
41.5 6.8) (p <0.0001), no difference in aneuploidy rate
was observed between these groups (30.0% vs. 26.1%) (p=0.66;
RR=0.93; 95% CI (0.68-1.27)). While controlling for female
age by using donor oocyte patients, the study’s preliminary
data support that paternal age does not affect aneuploidy
rates.
Key
words:
Male age, in vitro fertilization, donor oocyte,
aneuploidy rates, cytogenetics. |
